Antifungal activity of lawsone methyl ether in comparison with chlorhexidine

Journal of Oral Pathology and Medicine

Volumn 40, Issue 1, 2011, Pages 90-96

  Sritrairat, Nattapon ^a   Nukul, Narin ^a   Inthasame, Piyanut ^a   Sansuk, Attapon ^a   Prasirt, Jinda ^a   Leewatthanakorn, Thassin ^a   Piamsawad, Uayporn ^a   Dejrudee, Aree ^a   Panichayupakaranant, Pharkphoom ^a   Pangsomboon, Kanokporn ^a   Chanowanna, Nilnara ^b   Hintao, Janpim ^a   Teanpaisan, Rawee ^a   Chaethong, Wisut ^a   Yongstar, Pataraporn ^a   Pruphetkaew, Nannapat ^a   Chongsuvivatwong, Virasakdi ^a   Nittayananta, Wipawee ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b Dental Division   (Thailand)

Author keywords

Antifungal activity; Candida; Chlorhexidine; HIV; Lawsone methyl ether; Mouthwash

Indexed keywords

CHLORHEXIDINE; LAWSONE; LAWSONE METHYL ETHER; MOUTHWASH; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC REACTION; ANALYSIS OF VARIANCE; ANTIFUNGAL ACTIVITY; ARTICLE; BITTER TASTE; BURNING SENSATION; CANDIDA ALBICANS; CANDIDIASIS; CLINICAL EXAMINATION; CROSSOVER PROCEDURE; DENTURE; FEMALE; FUNGUS CULTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUTH HYGIENE; NONHUMAN; ODOR; PATIENT SATISFACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL ANALYSIS; THRUSH; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS, ORAL; CHLORHEXIDINE; CROSS-OVER STUDIES; DENTAL PROSTHESIS; DENTURES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MOUTHWASHES; NAPHTHOQUINONES; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 78650788399     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2010.00921.x     Document Type: Article

References (38)

1. Feigal DW, Katz MH, Greenspan D, et al. The prevalence of oral lesions in HIV infected homosexual and bisexual men: three San Francisco epidemiological cohorts. AIDS 1991; 5: 519-25.
2. Greenspan JS, Barr CE, Sciubba JJ, et al. U.S.A. Oral AIDS Collaborative Group. Oral manifestations of HIV infection. Oral Surg Oral Med Oral Pathol 1992; 73: 142-4.
3. Glick M, Muzyka BC, Lurie D, et al. Oral manifestations associated with HIV-related disease as markers for immune suppression and AIDS. Oral Surg Oral Med Oral Pathol 1994; 77: 344-9.
4. Nittayananta W, Chungpanich S. Oral lesions in a group of Thai people with AIDS. Oral Dis 1997; 3(Suppl. 1): S41-5.
5. Pereira-Cenci T, Del Bel Cury AA, Crielaard W, Ten Cate JM. Development of Candida-associated denture stomatitis: new insights. J Appl Oral Sci 2008; 16: 86-94.
6. Epstein JB, Vickars L, Spinelli J, Reece D. Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation. Oral Surg Oral Med Oral Pathol 1992; 72: 291-5.
7. Greenspan D, Greenspan JS. Management of the oral lesions of HIV infection. J Am Dent Assoc 1991; 122: 26-32.
8. Spencer PM, Jackson GG. Fungal and mycobacterial infections in patients infected with the human immunodeficiency virus. J Antimicrobe Chemother 1989; 23: 107-25.
9. Baily GG, Perry FM, Denning DW, et al. Fluconazole resistant candidosis in an HIV cohort. AIDS 1994; 8: 787-92.
10. Langslet A, Olsen I, Lie SO, Lokken P. Chlorhexidine treatment of oral candidiasis in seriously disease children. Acta Paediatr Scand 1974; 63: 806-11.
11. Nittayananta W, DeRouen TA, Arirachakaran P, et al. A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection. Oral Dis 2008; 14: 665-70.
12. Fransworth NR, Cordell GA. A review of some biologically active compounds isolated from plants as reported in the 1974-1975 literature. Lloydia 1976; 39: 420-55.
13. Triphathi RD, Srivastava HS, Dixit SN. A fungitoxic principle from leaves of Lawsonia inermis Lam. Experientia 1978; 34: 51-2.
14. Phadungcharoen T, Likhitwitayawuid K, Saifah E, et al. Antifungal compound from Impatiens balsamina leaves. Thai J Pharm Sci 1988; 13: 117-26.
15. Yang X, Summerhurst DK, Koval SF, Ficker C, Smith ML, Bernards MA. Isolation of an antimicrobial compound from Impatiens balsamina L. using bioassay-guided fractionation. Phytother Res 2001; 15: 676-80.
16. Little JE, Sproston TJ, Foote MW. Isolation and antifungal action of naturally occurring 2-methoxy-1, 4-naphthoquinone. J Biol Chem 1948; 174: 335-42.
17. Rodriguez S, Wolfender JL, Hakizamungu E, Hostettmann K. An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina. Planta Med 1995; 61: 362-4.
18. Reanmongkol W, Subhadhirasakul S, Panichayupakaranant P, Kim KM. Anti-allergic and anti-oxidative activities of some compounds from Thai medicinal plants. Pharm Biol 2003; 41: 592-7.
19. Panichayupakaranant P, Reanmongkol W. Evaluation of chemical stability and skin irritation of lawsone methyl ether in oral base. Pharm Biol 2002; 40: 429-32.
20. EC-Clearinghouse on Oral Problems Related to HIV Infection and WHO Collaborating Centre on Oral Manifestations of the Immunodeficiency Virus. Classification and diagnostic criteria for oral lesions in HIV infection. J Oral Pathol Med 1993; 22: 289-91.
21. Samaranayake LP, MacFarlane TW, Lamey PJ, Ferguson MM. A comparison of oral rinse and imprint sampling techniques for the detection of yeast, coliform and Staphylococcus aureus carriage in the oral cavity. J Oral Pathol 1986; 15: 386-8.
22. Bland JM, Altman DG. Multiple significance tests: the Bonferrorni method. BMJ 1995; 310: 170.
23. Bates D, Maechler M. lme4: Linear Mixed-Effects Models Using S4 Classes. Fit Linear and Generalized Linear Mixed-Effects Models. Available at: (accessed on 20 October, 2009).
24. Sakunphueak A, Panichayupakaranant P. Quantitative HPLC determination of naphthoquinones in Impatiens balsamina leaves. Planta Med 2008; 74: 1091.
25. Salem AM, Adams D, Newman HN, et al. Antimicrobial properties of 2 aliphatic amine and chlorhexidine in vitro and in saliva. J Clin Periodontol 1987; 14: 44-7.
26. Bobichon H, Bouchet P. Action of chlorhexidine on budding Candida albicans: scanning and transmission electron microscope study. Mycopathologia 1987; 100: 27-35.
27. Elferink JG, Booij HL. Interaction of chlorhexidine with yeast cells. Biochem Pharmacol 1974; 23: 1413-9.
28. Vaahtoniemi LH. Surface ultrastructure of intact and in situ chlorhexidine-treated human buccal cells. A method for scanning electron microscopy. Acta Odontol Scand 1997; 55: 277-81.
29. Hjeljord LG, Rolla G, Bonesvoll P. Chlorhexidine-protein interactions. J Periodontal Res Suppl 1973; 12: 11-6.
30. Bonesvoll P, Olsen I. Influence of teeth, plaque and dentures on the retention of chlorhexidine in the human oral cavity. J Clin Periodontol 1974; 1: 214-21.
31. Seymour RA, Meechan JG, Yates MS. Pharmacological control of dental caries and periodontal disease. In: Seymour RA, Meechan JG, Yates MS, eds. Pharmacology and dental therapeutics. Oxford: Oxford University Press, 1999; 179-96.
32. Pizzo G, Giuliana G. Antifungal activity of chlorhexidine containing mouthrinses. An in vitro study. Minerva Stomatol 1998; 47: 665-71.
33. Patel M, Shackleton JA, Coogan MM, Galpin J. Antifungal effect of mouth rinses on oral Candida counts and salivary flow in treatment-naïve HIV-infected patients. AIDS Patient Care STDS 2008; 22: 613-8.
34. Addy M, Moran J, Davis RM, et al. The effect of single morning and evening rinses of chlorhexidine on the development of tooth staining and plaque accumulation. A blind crossover trial. J Clin Periodontol 1982; 9: 134-40.
35. Revankar SG, Kirkpatrick WR, McAtee RK, et al. A randomized trial of continuous or intermittent therapy with fluconazole for oropharyngeal candidiasis in HIV-infected patients: clinical outcomes and development of fluconazole resistance. Am J Med 1998; 105: 7-11.
36. Patton LL, Bonito AJ, Shugars DA. A systematic review of the effectiveness of antifungal drugs for the prevention and treatment of oropharyngeal candidiasis in HIV-positive patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 170-9.
37. Freedberg KA, Paltiel AD. Cost effectiveness of prophylaxis for opportunistic infections in AIDS. An overview and methodological discussion. Pharmacoeconomics 1998; 14: 165-74.
38. Nyst MJ, Perriens JH, Kimputu L, Lumbila M, Nelson AM, Piot P. Gentian violet, ketoconazole and nystatin in oropharyngeal and esophageal candidiasis in Zairian AIDS patients. Ann Soc Belg Med Trop 1992; 72: 45-52.