Occult pulmonary hemorrhage as a rare presentation of propylthiouracil- induced vasculitis

Pediatrics

Volumn 127, Issue 1, 2011, Pages

  Tu, Yu Ling ^a,b   Tsai, Yi Chan ^a,b   Huang, Jing Long ^a,b   Yao, Tsung Chieh ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Anemia; Antineutrophil cytoplasmic antibody; Propylthiouracil; Pulmonary hemorrhage; Vasculitis

Indexed keywords

ANTINUCLEAR ANTIBODY; AZATHIOPRINE; CARBIMAZOLE; CORTICOSTEROID; CRYOGLOBULIN; DNA ANTIBODY; METHYLPREDNISOLONE; MYELOBLASTIN; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE; PROPYLTHIOURACIL; RHEUMATOID FACTOR; VIRUS ANTIBODY;

ADOLESCENT; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FATIGUE; FEMALE; FEVER; GRAVES DISEASE; HUMAN; HUMAN TISSUE; IRON THERAPY; LABORATORY TEST; LEUKOCYTOCLASTIC VASCULITIS; LUNG HEMORRHAGE; LUNG LAVAGE; NEPHRITIS; OCCULT BLOOD; PHYSICAL EXAMINATION; POLYARTHRITIS; PRIORITY JOURNAL; PURPURA; RECURRENT DISEASE; SEROLOGY; SKIN BIOPSY; THORAX RADIOGRAPHY; THYROID FUNCTION TEST; URTICARIA;

ADOLESCENT; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTITHYROID AGENTS; FEMALE; HEMORRHAGE; HUMANS; LUNG DISEASES; PROPYLTHIOURACIL;

EID: 78650784507     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-0138     Document Type: Article

References (17)

1. Stankus SJ, Johnson NT. Propylthiouracilinduced hypersensitivity vasculitis presenting as respiratory failure. Chest. 1992;102(5):1595-1596
2. Dolman KM, Gans ROB, Vervaat TJ, et al. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet. 1993;342(8872):651-652 (Pubitemid 23271506)
3. Primack SL, Miller RR, Müller NL. Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 1995;164(2):295-300
4. Yao TC, Hung IJ, Jaing TH, Yang CP. Pitfalls in the diagnosis of idiopathic pulmonary haemosiderosis. Arch Dis Child. 2002;86(6):436-438
5. Noh JY, Yasuda S, Sato S, et al. Clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis caused by antithyroid drugs. J Clin Endocrinol Metab. 2009;94(8):2806-2811
6. Aloush V, Litinsky I, Caspi D, Elkayam O. Prophythiouracil-induced autoimmune syndromes: two distinct clinical presentations with different course and management. Semin Arthritis Rheum. 2006;36(1):4-9 (Pubitemid 44144499)
7. Hsu MT, Chen YC, Wu CJ, et al. Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis and pulmonary hemorrhage associated with propylthiouracil: a case report and review of the literature. Acta Nephrol. 2006;20(1):48-56
8. Singer PA, Cooper DS, Levy EG, et al. Treatment guidelines for patients with hyperthyroidism and hypothyroidism. Standards of Care Committee, American Thyroid Association. JAMA. 1995;273(10):808-812
9. Luqmani RA, Pathare S, Kwok-Fai TL. How to diagnose and treat secondary forms of vasculitis. Best Pract Res Clin Rheumatol. 2005;19(2):321-336 (Pubitemid 40568183)
10. Gunton JE, Stiel J, Caterson RJ, McElduff A. Clinical case seminar: anti-thyroid drugs and antineutrophil cytoplasmic antibody positive vasculitis - a case report and review of the literature. J Clin Endocrinol Metab. 1999;84(1):13-16 (Pubitemid 29036673)
11. Harper L, Cockwell P, Savage CO. Case of propylthiouracil-induced ANCA associated small vessel vasculitis. Nephrol Dial Transplant. 1998;13(2):455-458 (Pubitemid 28062213)
12. Sera N, Ashizawa K, Ando T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease. Thyroid. 2000;10(7):595-599 (Pubitemid 30670620)
13. Waldhauser L, Uetrecht J. Oxidation of propylthiouracil to reactive metabolites by activated neutrophils: implications for agranulocytosis. Drug Metab Dispos. 1991;19(2):354-359
14. Wolf D, Ben-Yehuda A, Okon E, Naparstek Y. Nodular vasculitis associated with propylthiouracil therapy. Cutis. 1992;49(4):253-255
15. Jacobs EM, Hartkamp A, Kaasjager HA. PTU-associated cutaneous vasculitis with ANCA anti-MPO and anti-PR3 antibodies. Neth J Med. 2003;61(9):296-299 (Pubitemid 39089428)
16. Gao Y, Chen M, Ye H, Yu F, Guo XH, Zhao MH. Long-term outcomes of patients with propylthiouracil-induced anti-neutrophil cytoplasmic auto-antibody associated vasculitis. Rheumatology (Oxford). 2008;47(10):1515-1520
17. Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M. Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides. Arthritis Res Ther. 2005;7(5):R1072-R1081