Will blood tell? three recent articles demonstrate genetic selection in tibetans

High Altitude Medicine and Biology

Volumn 11, Issue 4, 2010, Pages 307-308

  Rupert, Jim ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALTITUDE; ALTITUDE ACCLIMATIZATION; BLOOD; CHINA; EDITORIAL; GENETIC SELECTION; HEREDITY; HUMAN; HYPOXIA; PRIORITY JOURNAL;

ACCLIMATIZATION; ALTITUDE; ASIAN CONTINENTAL ANCESTRY GROUP; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ETHNIC GROUPS; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HEMOGLOBINS; HUMANS; PROCOLLAGEN-PROLINE DIOXYGENASE; SELECTION, GENETIC; TIBET;

EID: 78650782589     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2010.1052     Document Type: Editorial

References (7)

1. Beall C.M. (2000). Tibetan and Andean patterns of adaptation to high-altitude hypoxia. Hum. Biol. 72:201-228.
2. Beall C.M., Brittenha, G.M., Strohl K.P., Blangero J., Williams- Blangero S., Goldstein M.C., Decker M.J., Vargas E., Villena M., Soria R., et al. (1998). Hemoglobin concentration of highaltitude Tibetans and Bolivian Aymara. Am. J. Phys. Anthropol. 106:385-400.
3. Beall C.M., Cavalleri G.L., Deng L., Elston R.C., Gao Y., Knight J., Li C., Li J.C., Liang Y., McCormack M., et al. (2010). Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc. Natl. Acad. Sci. USA. 107:11459-11464.
4. Bigham A.W., Mao X., Mei R., Brutsaert T., Wilson M.J., Julian C.G., Parra E.J., Akey J.M., Moore L.G., and Shriver M.D. (2009). Identifying positive selection candidate loci for highaltitude adaptation in Andean populations. Hum. Genomics. 4:79-90.
5. Simonson T.S., Yang Y., Huff C.D., Yun H., Qin G., Witherspoon D.J., Bai Z., Lorenzo F.R., Xing J., Jorde L.B., et al. (2010). Genetic evidence for high-altitude adaptation in Tibet. Science. 329:72-75.
6. Voight B.F., Kudaravall, S., Wen X., and Pritchard J.K. (2006). A map of recent positive selection in the human genome. PLoS Biol. 4:e72.
7. Yi X., Liang Y., Huerta-Sanchez E., Jin X., Cuo Z.X., Pool J.E., Xu X., Jiang H., Vinckenbosch N., Korneliussen T.S., et al. (2010). Sequencing of 50 human exomes reveals adaptation to high altitude. Science. 329:75-78.