Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites-the cardioprotectant dexrazoxane as a model case

Journal of Chromatography A

Volumn 1218, Issue 3, 2011, Pages 416-426

  Kovaříková, Petra ^a   Stariat, Ján ^a   Klimeš, Jiří ^a   Hrušková, Kateřina ^a   Vávrová, Kateřina ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Bisdioxopiperazine; Dexrazoxane; Hydrophilic interaction liquid chromatography; LC MS; Polar drug

Indexed keywords

BISDIOXOPIPERAZINE; DEXRAZOXANE; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; LC-MS; POLAR DRUGS;

ACETONITRILE; AMMONIUM COMPOUNDS; BIOMOLECULES; DRUG INTERACTIONS; HYDROPHILICITY; ISOMERS; LIQUIDS; MATHEMATICAL MODELS; METABOLISM; METABOLITES; PHASE SEPARATION; SILICA;

LIQUID CHROMATOGRAPHY;

1,2 PROPANEDIAMINE N,N' DIACETAMIDE N,N' DIACETIC ACID; ACETONITRILE; AMMONIUM FORMATE; AMPHOLYTE; DRUG METABOLITE; EDETIC ACID; RAZOXANE; SILICON DIOXIDE;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HEART PROTECTION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; SEPARATION TECHNIQUE; TEMPERATURE;

CARDIOVASCULAR AGENTS; CHROMATOGRAPHY, LIQUID; ETHYLENEDIAMINES; GLYCINE; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; RAZOXANE; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 78650750565     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.11.050     Document Type: Article

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