Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 172-185

  Miyamoto, Yasufumi ^a   Banno, Yoshihiro ^a   Yamashita, Tohru ^a   Fujimoto, Tatsuhiko ^a   Oi, Satoru ^a   Moritoh, Yusuke ^a   Asakawa, Tomoko ^a   Kataoka, Osamu ^a   Takeuchi, Koji ^a   Suzuki, Nobuhiro ^a   Ikedo, Koji ^a   Kosaka, Takuo ^a   Tsubotani, Shigetoshi ^a   Tani, Akiyoshi ^a   Funami, Miyuki ^a   Amano, Michiko ^a   Yamamoto, Yoshio ^a   Aertgeerts, Kathleen ^b   Yano, Jason ^b   Maezaki, Hironobu ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Takeda San Diego Inc   (United States)

Author keywords

Bidentate interaction; Dipeptidyl peptidase IV (DPP 4); Structure based drug design (SBDD)

Indexed keywords

1 {[5 (AMINOMETHYL) 2 METHYL 4 (4 METHYLPHENYL) 6 (2 METHYLPROPYL)PYRIDIN 3 YL]ACETYL}PROLINAMIDE; 3 PYRIDYLACETAMIDE DERIVATIVE; ARGININE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HYDROGEN BOND; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETAMIDES; ARGININE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650744466     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.038     Document Type: Article

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