Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange

ACS Nano

Volumn 4, Issue 12, 2010, Pages 7229-7240

  Yang, Jian ^a   Kickhoefer, Valerie A ^a   Ng, Benny C ^a   Gopal, Ajaykumar ^a   Bentolila, Laurent A ^a,b   John, Scott ^a   Tolbert, Sarah H ^a,b   Rome, Leonard H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA NANOSYSTEMS INSTITUTE   (United States)

Author keywords

drug delivery vehicle; half vault exchange; major vault protein; nanoparticles; ribonucleoprotein; vault; vault dynamics

Indexed keywords

DRUG DELIVERY VEHICLES; HALF VAULT EXCHANGE; MAJOR VAULT PROTEINS; RIBONUCLEOPROTEINS; VAULT; VAULT DYNAMICS;

CELLS; CYTOLOGY; DRUG DELIVERY; DYNAMICS; ENERGY TRANSFER; FLUORESCENCE; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

PROTEINS;

LUNG RESISTANCE PROTEIN; MACROGOL DERIVATIVE; NANOPARTICLE; RIBONUCLEOPROTEIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOPLASM; DIFFUSION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SMALL ANGLE SCATTERING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; X RAY DIFFRACTION;

ANIMALS; CELL LINE, TUMOR; CYTOPLASM; DIFFUSION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; NANOPARTICLES; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SCATTERING, SMALL ANGLE; VAULT RIBONUCLEOPROTEIN PARTICLES; X-RAY DIFFRACTION;

EID: 78650729597     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102051r     Document Type: Article

References (43)

1. Wang, M.; Thanou, M. Targeting Nanoparticles to Cancer Pharmacol. Res. 2010, 62, 90-99
2. Singh, R.; Lillard, J. W., Jr Nanoparticle-Based Targeted Drug Delivery Exp. Mol. Pathol 2009, 86, 215-223
3. Mikyas, Y.; Makabi, M.; Raval-Fernandes, S.; Harrington, L.; Kickhoefer, V. A.; Rome, L. H.; Stewart, P. L. Cryoelectron Microscopy Imaging of Recombinant and Tissue Derived Vaults: Localization of the MVP N Termini and VPARP J. Mol. Biol. 2004, 344, 91-105
4. Kedersha, N. L.; Rome, L. H. Isolation and Characterization of a Novel Ribonucleoprotein Particle: Large Structures Contain a Single Species of Small RNA J. Cell. Biol 1986, 103, 699-709
5. Kedersha, N. L.; Heuser, J. E.; Chugani, D. C.; Rome, L. H. Vaults. III. Vault Ribonucleoprotein Particles Open into Flower-Like Structures with Octagonal Symmetry J. Cell. Biol 1991, 112, 225-235
6. Tanaka, H.; Kato, K.; Yamashita, E.; Sumizawa, T.; Zhou, Y.; Yao, M.; Iwasaki, K.; Yoshimura, M.; Tsukihara, T. The Structure of Rat Liver Vault at 3.5 Angstrom Resolution Science 2009, 323, 384-388
7. Kong, L. B.; Siva, A. C.; Rome, L. H.; Stewart, P. L. Structure of the Vault, a Ubiquitous Celular Component Structure 1999, 7, 371-379
8. Kickhoefer, V. A.; Siva, A. C.; Kedersha, N. L.; Inman, E. M.; Ruland, C.; Streuli, M.; Rome, L. H. The 193-kD Vault Protein, VPARP, Is a Novel Poly(ADP-ribose) Polymerase J. Cell. Biol 1999, 146, 917-928
9. Kickhoefer, V. A.; Stephen, A. G.; Harrington, L.; Robinson, M. O.; Rome, L. H. Vaults and Telomerase Share a Common Subunit, TEP1 J. Biol. Chem. 1999, 274, 32712-32717
10. Suprenant, K. A. Vault Ribonucleoprotein Particles: Sarcophagi, Gondolas, or Safety Deposit Boxes Biochemistry 2002, 41, 14447-14454
11. Berger, W.; Steiner, E.; Grusch, M.; Elbling, L.; Micksche, M. Vaults and the Major Vault Protein: Novel Roles in Signal Pathway Regulation and Immunity Cell. Mol. Life Sci. 2009, 66, 43-61
12. Stephen, A. G.; Raval-Fernandes, S.; Huynh, T.; Torres, M.; Kickhoefer, V. A.; Rome, L. H. Assembly of Vault-Like Particles in Insect Cells Expressing Only the Major Vault Protein J. Biol. Chem. 2001, 276, 23217-23220
13. Esfandiary, R.; Kickhoefer, V. A.; Rome, L. H.; Joshi, S. B.; Middaugh, C. R. Structural Stability of Vault Particles J. Pharm. Sci. 2009, 98, 1376-1386
14. Goldsmith, L. E.; Yu, M.; Rome, L. H.; Monbouquette, H. G. Vault Nanocapsule Dissociation into Halves Triggered at Low pH Biochemistry 2007, 46, 2865-2875
15. Anderson, D. H.; Kickhoefer, V. A.; Sievers, S. A.; Rome, L. H.; Eisenberg, D. Draft crystal Structure of the Vault Shell at 9-Angstrom Resolution PLoS Biol. 2007, 5, 2661-2670
16. Kickhoefer, V. A.; Han, M.; Raval-Fernandes, S.; Poderycki, M. J.; Moniz, R. J.; Vaccari, D.; Silvestry, M.; Stewart, P. L.; Kelly, K. A.; Rome, L. H. Targeting Vault Nanoparticles to Specific Cell Surface Receptors ACS Nano 2009, 3, 27-36
17. Lai, C. Y.; Wiethoff, C. M.; Kickhoefer, V. A.; Rome, L. H.; Nemerow, G. R. Vault Nanoparticles Containing an Adenovirus-Derived Membrane Lytic Protein Facilitate Toxin and Gene Transfer ACS Nano 2009, 3, 691-699
18. Goldsmith, L. E.; Pupols, M.; Kickhoefer, V. A.; Rome, L. H.; Monbouquette, H. G. Utilization of a Protein "Shuttle" to Load Vault Nanocapsules with Gold Probes and Proteins ACS Nano 2009, 3, 3175-3183
19. Champion, C. I.; Kickhoefer, V. A.; Liu, G.; Moniz, R. J.; Freed, A. S.; Bergmann, L. L.; Vaccari, D.; Raval-Fernandes, S.; Chan, A. M.; Rome, L. H. A Vault Nanoparticle Vaccine Induces Protective Mucosal Immunity PLoS ONE 2009, 4 e5409
20. Kickhoefer, V. A.; Garcia, Y.; Mikyas, Y.; Johansson, E.; Zhou, J. C.; Raval-Fernandes, S.; Minoofar, P.; Zink, J. I.; Dunn, B.; Stewart, P. L. Engineering of Vault Nanocapsules with Enzymatic and Fluorescent Properties Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 4348-4352
21. van Zon, A.; Mossink, M. H.; Schoester, M.; Scheffer, G. L.; Scheper, R. J.; Sonneveld, P.; Wiemer, E. A. Structural Domains of Vault Proteins: a Role for the Coiled Coil Domain in Vault Assembly Biochem. Biophys. Res. Commun. 2002, 291, 535-541
22. Ng, B. C.; Yu, M.; Gopal, A.; Rome, L. H.; Monbouquette, H. G.; Tolbert, S. H. Encapsulation of Semiconducting Polymers in Vault Protein Cages Nano Lett. 2008, 8, 3503-3509
23. Poderycki, M. J.; Kickhoefer, V. A.; Kaddis, C. S.; Raval-Fernandes, S.; Johansson, E.; Zink, J. I.; Loo, J. A.; Rome, L. H. The Vault Exterior Shell Is a Dynamic Structure That Allows Incorporation of Vault-associated Proteins into Its Interior Biochemistry 2006, 45, 12184-12193
24. Yu, M.; Ng, B. C.; Rome, L. H.; Tolbert, S. H.; Monbouquette, H. G. Reversible pH Lability of Cross-linked Vault Nanocapsules Nano Lett. 2008, 8, 3510-3515
25. Slesina, M.; Inman, E. M.; Moore, A. E.; Goldhaber, J. I.; Rome, L. H.; Volknandt, W. Movement of Vault Particles Visualized by GFP-Tagged Major Vault Protein Cell Tissue Res. 2006, 324, 403-410
26. van Zon, A.; Mossink, M. H.; Schoester, M.; Houtsmuller, A. B.; Scheffer, G. L.; Scheper, R. J.; Sonneveld, P.; Wiemer, E. A. The Formation of Vault-Tubes: a Dynamic Interaction Between Vaults and Vault PARP J. Cell. Sci 2003, 116, 4391-4400
27. van Zon, A.; Mossink, M. H.; Houtsmuller, A. B.; Schoester, M.; Scheffer, G. L.; Scheper, R. J.; Sonneveld, P.; Wiemer, E. A. Vault Mobility Depends in Part on Microtubules and Vaults Can Be Recruited to the Nuclear Envelope Exp. Cell Res. 2006, 312, 245-255
28. Jacobson, K.; Wojcieszyn, J. The Translational Mobility of Substances within the Cytoplasmic Matrix Proc. Natl. Acad. Sci. U.S.A. 1984, 81, 6747-6751
29. Slesina, M.; Inman, E. M.; Rome, L. H.; Volknandt, W. Nuclear Localization of the Major Vault Protein in U373 Cells Cell Tissue Res. 2005, 321, 97-104
30. van Zon, A.; Mossink, M. H.; Scheper, R. J.; Sonneveld, P.; Wiemer, E. A. The Vault Complex Cell. Mol. Life Sci. 2003, 60, 1828-1837
31. Zheng, C. L.; Sumizawa, T.; Che, X. F.; Tsuyama, S.; Furukawa, T.; Haraguchi, M.; Gao, H.; Gotanda, T.; Jueng, H. C.; Murata, F. Characterization of MVP and VPARP Assembly into Vault Ribonucleoprotein Complexes Biochem. Biophys. Res. Commun. 2005, 326, 100-107
32. Kickhoefer, V. A.; Liu, Y.; Kong, L. B.; Snow, B. E.; Stewart, P. L.; Harrington, L.; Rome, L. H. The Telomerase/Vault-Associated Protein TEP1 Is Required for Vault RNA Stability and Its Association with the Vault Particle J. Cell. Biol. 2001, 152, 157-164
33. Luby-Phelps, K.; Castle, P. E.; Taylor, D. L.; Lanni, F. Hindered Diffusion of Inert Tracer Particles in the Cytoplasm of Mouse 3T3 Cells Proc. Natl. Acad. Sci. U.S.A. 1987, 84, 4910-4913
34. Fung, Y. C. Biomechanics: Mechanical Properties of Living Tissues, 2 nd ed.; Springer: New York, 1993.
35. Siva, A. C.; Raval-Fernandes, S.; Stephen, A. G.; LaFemina, M. J.; Scheper, R. J.; Kickhoefer, V. A.; Rome, L. H. Up-Regulation of Vaults May Be Necessary But Not Sufficient for Multidrug Resistance Int. J. Cancer 2001, 92, 195-202
36. Silva, P.; West, C. M.; Slevin, N.; Valentine, H.; Ryder, W. D.; Hampson, L.; Bibi, R.; Sloan, P.; Thakker, N.; Homer, J.; Hampson, I. Tumor Expression of Major Vault Protein Is an Adverse Prognostic Factor for Radiotherapy Outcome in Oropharyngeal Carcinoma Int. J. Radiat. Oncol., Biol., Phys. 2007, 69, 133-140
37. Patterson, G. H.; Lippincott-Schwartz, J. A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells Science 2002, 297, 1873-1877
38. Konarev, P. V.; Volkov, V. V.; Sokolova, A. V.; Koch, M. H. J.; Svergun, D. I. PRIMUS: a Windows PC-Based System for Small-Angle Scattering Data Analysis J. Appl. Crystallogr. 2003, 36, 1277-1282
39. Svergun, D. Determination of the Regularization Parameter in Indirect-Transform Methods Using Perceptual Criteria J. Appl. Crystallogr. 1992, 25, 495-503
40. Svergun, D. I. Restoring Low Resolution Structure of Biological Macromolecules from Solution Scattering Using Simulated Annealing Biophys. J. 1999, 76, 2879-2886
41. Wriggers, W.; Milligan, R. A.; McCammon, J. A. Situs: A Package for Docking Crystal Structures into Low-Resolution Maps from Electron Microscopy J. Struct. Biol. 1999, 125, 185-195
42. Svergun, D.; Barberato, C.; Koch, M. H. J. CRYSOL: A Program to Evaluate X-Ray Solution Scattering of Biological Macromolecules from Atomic Coordinates J. Appl. Crystallogr. 1995, 28, 768-773
43. Humphrey, W.; Dalke, A.; Schulten, K. VMD: Visual Molecular Dynamics J. Mol. Graphics 1996, 14, 33-38