Novel 9a,11-bridged azalides: One-pot synthesis of N′-substituted 2-imino-1,3-oxazolidines condensed to an azalide aglycone

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 556-566

  Ištuk, Zorica Marušić ^a,c   Čikoš, Ana ^a,c   Gembarovski, Dubravka ^a,c   Lazarevski, Gorjana ^a,c   Dilović, Ivica ^b   Matković Čalogović, Dubravka ^b   Kragol, Goran ^a,c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c Galapagos Research Centre   (Croatia)

Author keywords

2 Imino 1,3 oxazolidine; Azalide; Macrolide; Mukaiyama reagent

Indexed keywords

3 DECLADINOSYL 9 DEOXO 9 DIHYDRO 9A (N' BENZYLTHIOCARBAMOYL) 6 O METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 3 DECLADINOSYL 9 DEOXO 9 DIHYDRO 9A (N' BENZYLTHIOCARBAMOYL) 9A AZA 9A HOMOERYTHROMYCIN A; 9 DEOXO 9 DIHYDRO 9A (N' BENZYLTHIOCARBAMOYL) 6 O METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 9 DEOXO 9 DIHYDRO 9A (N' BENZYLTHIOCARBAMOYL) 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 3 DECLADINOSYL 3 KETO 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 3 DECLADINOSYL 3,6 HEMIKETAL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 3 DECLADINOSYL 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 3 DECLADINOSYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' BENZYLCARBONIMIDOYL) 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' ISOPROPYLCARBONIMIDOYL) 3 DECLADINOSYL 3 KETO 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' ISOPROPYLCARBONIMIDOYL) 3 DECLADINOSYL 3,6 HEMIKETAL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' ISOPROPYLCARBONIMIDOYL) 3 DECLADINOSYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' ISOPROPYLCARBONIMIDOYL) 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O (N' ISOPROPYLCARBONIMIDOYL) 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' (1 NAPHTYL)CARBONIMIDOYL] 3 DECLADINOSYL 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' (1 NAPHTYL)CARBONIMIDOYL] 3 DECLADINOSYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' (1 NAPHTYL)CARBONIMIDOYL] 6 O METHYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' (1 NAPHTYL)CARBONIMIDOYL] 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' [4 (3 METHOXY)BIPHENYL]CARBONIMIDOYL] 3 DECLADINOSYL 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; 9A,11 O [N' [4 (3 METHOXY)BIPHENYL]CARBONIMIDOYL] 9 DEOXO 9A AZA 9A HOMOERYTHROMYCIN A; AGLYCONE; ANTIINFECTIVE AGENT; BENZYL DERIVATIVE; CLADINOSE; LACTONE; SUGAR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DEPROTECTION REACTION; NONHUMAN; ONE POT SYNTHESIS;

AZA COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OXAZOLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 78650727349     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.061     Document Type: Article

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