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Volumn 28, Issue SUPPL. 1, 2010, Pages 169-181

Predicting direct costs of HIV care during the first year of darunavir-based highly active antiretroviral therapy using CD4 cell counts: Evidence from POWER

Author keywords

[No Author keywords available]

Indexed keywords

DARUNAVIR PLUS RITONAVIR; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; LOPINAVIR PLUS RITONAVIR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA;

EID: 78650726135     PISSN: 11707690     EISSN: 11792027     Source Type: Journal    
DOI: 10.2165/11587510-000000000-00000     Document Type: Article
Times cited : (3)

References (47)
  • 1
    • 33750999624 scopus 로고    scopus 로고
    • British HIV Association (BHIVA) guidelines for the treatment of HIVinfected adults with antiretroviral therapy (2006)
    • Gazzard B, Bernard AJ, Boffito M, et al. British HIV Association (BHIVA) guidelines for the treatment of HIVinfected adults with antiretroviral therapy (2006). HIV Med 2006; 7: 487-503
    • (2006) HIV Med , Issue.7 , pp. 487-503
    • Gazzard, B.1    Bernard, A.J.2    Boffito, M.3
  • 2
    • 55649108869 scopus 로고    scopus 로고
    • US Department of Health and Human Services (DHHS) Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents; 2008 Nov 3 [online]. Available from [Accessed 2009 Dec 10]
    • US Department of Health and Human Services (DHHS), Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents; 2008 Nov 3 [online]. Available from URL: Http://aidsinfo.nih.gov/Guide lines/Default.aspx? MenuItem=Guidelines [Accessed 2009 Dec 10]
    • Panel on Antiretroviral Guidelines for Adults and Adolescents
  • 3
    • 33747122666 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel
    • Hammer SM, Saag MS, Schechter M, et al. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel. JAMA 2006; 296: 827-43
    • (2006) JAMA , vol.296 , pp. 827-43
    • Hammer, S.M.1    Saag, M.S.2    Schechter, M.3
  • 4
    • 78650744354 scopus 로고    scopus 로고
    • European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe. Oct [online]. Available from URL: Accessed 2009 Dec 10]
    • European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe. 2008 Oct [online]. Available from URL: Http://www.europeanaidsclinicalsociety.org/guidelines.asp [Accessed 2009 Dec 10]
    • (2008)
  • 5
    • 20144366701 scopus 로고    scopus 로고
    • Risk of AIDS and death at given HIV-RNA and CD4 cell counts, in relation to specific antiretroviral drugs in the regimen
    • Olsen CH, Gatell J, Ledergerber B, et al. Risk of AIDS and death at given HIV-RNA and CD4 cell counts, in relation to specific antiretroviral drugs in the regimen. AIDS 2005; 19: 319-30
    • (2005) AIDS , vol.19 , pp. 319-30
    • Olsen, C.H.1    Gatell, J.2    Ledergerber, B.3
  • 6
    • 34547427629 scopus 로고    scopus 로고
    • The CD4 lymphocyte count and risk of clinical progression: The T cell in HIV infection and disease
    • Phillips AN, Lundgren JD. The CD4 lymphocyte count and risk of clinical progression: The T cell in HIV infection and disease. Curr Opin HIV AIDS 2006; 1: 43-9
    • (2006) Curr Opin HIV AIDS , vol.1 , pp. 43-9
    • Phillips, A.N.1    Lundgren, J.D.2
  • 7
    • 70449356789 scopus 로고    scopus 로고
    • Higher risk of AIDS or death in patients with lower CD4 cell counts after virally suppressive HAART
    • Taiwo BO, Li X, Palella F, et al. Higher risk of AIDS or death in patients with lower CD4 cell counts after virally suppressive HAART. HIV Med 2009; 10: 657-60
    • (2009) HIV Med , vol.10 , pp. 657-60
    • Taiwo, B.O.1    Li, X.2    Palella, F.3
  • 8
    • 59849099091 scopus 로고    scopus 로고
    • Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa
    • Lawn SD, Little F, Bekker LG, et al. Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa. AIDS 2009; 23: 335-42
    • (2009) AIDS , vol.23 , pp. 335-42
    • Lawn, S.D.1    Little, F.2    Bekker, L.G.3
  • 9
    • 33751515147 scopus 로고    scopus 로고
    • CD4+ count-guided interruption of antiretroviral treatment
    • Strategies for Management of Antiretroviral Therapy (SMART) Study Group
    • Strategies for Management of Antiretroviral Therapy (SMART) Study Group, El-Sadr WM, Lundgren JD, et al. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med 2006; 355: 2283-96
    • (2006) N Engl J Med , vol.355 , pp. 2283-96
    • El-Sadr, W.M.1    Lundgren, J.D.2
  • 10
    • 42449086328 scopus 로고    scopus 로고
    • CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
    • Baker JV, Peng G, Rapkin J, et al. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS 2008; 22: 841-8
    • (2008) AIDS , vol.22 , pp. 841-8
    • Baker, J.V.1    Peng, G.2    Rapkin, J.3
  • 11
    • 55249101754 scopus 로고    scopus 로고
    • HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies
    • Monforte A, Abrams D, Pradier C, et al. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies. AIDS 2008; 22: 2143-53
    • (2008) AIDS , vol.22 , pp. 2143-53
    • Monforte, A.1    Abrams, D.2    Pradier, C.3
  • 12
    • 85062055676 scopus 로고    scopus 로고
    • Liver-related deaths in persons infected with the human immunodeficiency virus: The D:A:D study
    • Weber R, Sabin CA, Friis-Møller N, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: The D:A:D study. Arch Intern Med 2006; 166: 1632-41
    • (2006) Arch Intern Med , vol.166 , pp. 1632-41
    • Weber, R.1    Sabin, C.A.2    Friis-Møller, N.3
  • 13
    • 69849114151 scopus 로고    scopus 로고
    • Cancer risk in HIV-infected persons: Influence of CD4(+) count
    • Clifford GM, Franceschi S. Cancer risk in HIV-infected persons: Influence of CD4(+) count. Future Oncol 2009; 5: 669-78
    • (2009) Future Oncol , vol.5 , pp. 669-78
    • Clifford, G.M.1    Franceschi, S.2
  • 14
    • 52249121996 scopus 로고    scopus 로고
    • Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men
    • Kaplan RC, Kingsley LA, Gange SJ, et al. Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS 2008; 22: 1615-24
    • (2008) AIDS , vol.22 , pp. 1615-24
    • Kaplan, R.C.1    Kingsley, L.A.2    Gange, S.J.3
  • 15
    • 78650741667 scopus 로고    scopus 로고
    • The impact of disease stage on direct medical costs of HIVmanagement: A review of the international literature
    • Levy A, Johnston K, Annemans L, et al. The impact of disease stage on direct medical costs of HIVmanagement: A review of the international literature. PharmacoEconomics 2010; 28 Suppl. 1: 35-47
    • (2010) PharmacoEconomics , vol.28 , Issue.SUPPL. 1 , pp. 35-47
    • Levy, A.1    Johnston, K.2    Annemans, L.3
  • 16
    • 0035869435 scopus 로고    scopus 로고
    • The cost effectiveness of combination antiretroviral therapy for HIV disease
    • Freedberg KA, Losina E, Weinstein MC, et al. The cost effectiveness of combination antiretroviral therapy for HIV disease. N Eng J Med 2001; 344: 824-31
    • (2001) N Eng J Med , vol.344 , pp. 824-31
    • Freedberg, K.A.1    Losina, E.2    Weinstein, M.C.3
  • 17
    • 0035329587 scopus 로고    scopus 로고
    • Long-term impact of highly active antiretroviral therapy on HIV-related health care costs
    • Keiser P, Nassar N, Kvanli MB, et al. Long-term impact of highly active antiretroviral therapy on HIV-related health care costs. J Acquir Immune Defic Syndr 2001; 27: 14-9
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 14-9
    • Keiser, P.1    Nassar, N.2    Kvanli, M.B.3
  • 19
    • 33645058159 scopus 로고    scopus 로고
    • Distribution of healthcare expenditures for HIV-infected patients
    • Chen RY, Accortt NA, Westfall AO, et al. Distribution of healthcare expenditures for HIV-infected patients. Clin Infect Dis 2006; 42: 1003-10
    • (2006) Clin Infect Dis , vol.42 , pp. 1003-10
    • Chen, R.Y.1    Accortt, N.A.2    Westfall, A.O.3
  • 20
    • 36148976506 scopus 로고    scopus 로고
    • Analysis of costs by CD4 count category for the darunavir/r 600/100 mg bid and control protease inhibitor arms of the POWER 1 and 2 trials
    • Hill A, Hemmett L, Wilson B. Analysis of costs by CD4 count category for the darunavir/r 600/100 mg bid and control protease inhibitor arms of the POWER 1 and 2 trials. HIV Clin Trials 2007; 8: 303-10
    • (2007) HIV Clin Trials , vol.8 , pp. 303-10
    • Hill, A.1    Hemmett, L.2    Wilson, B.3
  • 21
    • 34548565745 scopus 로고    scopus 로고
    • Predicting HIV care costs using CD4 counts from clinical trials
    • Hill A, Gebo K. Predicting HIV care costs using CD4 counts from clinical trials. Am J Manag Care 2007; 13: 524-8
    • (2007) Am J Manag Care , vol.13 , pp. 524-8
    • Hill, A.1    Gebo, K.2
  • 22
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, et al. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother 2005; 49: 2314-21
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2314-21
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3
  • 23
    • 10744226241 scopus 로고    scopus 로고
    • Novel bis-tetrahydrofuranylurethane- containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro
    • Koh Y, Nakata H, Maeda K, et al. Novel bis-tetrahydrofuranylurethane- containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother 2003; 47: 3123-9
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3123-9
    • Koh, Y.1    Nakata, H.2    Maeda, K.3
  • 24
    • 34047207229 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
    • Clotet B, Bellos N, Molina JM, et al. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials. Lancet 2007; 369: 1169-78
    • (2007) Lancet , vol.369 , pp. 1169-78
    • Clotet, B.1    Bellos, N.2    Molina, J.M.3
  • 26
    • 78650733430 scopus 로고    scopus 로고
    • HIV cost and services utilization study (HCSUS). Fact sheet: Agency for Health Care Research and Quality, Rockville, MD, USA; [online]. Available from URL: Accessed Dec 10
    • HIV cost and services utilization study (HCSUS). Fact sheet: Agency for Health Care Research and Quality, Rockville, MD, USA; [online]. Available from URL: Http://www.ahrq.gov/data/hcsus.htm [Accessed 2009 Dec 10]
    • (2009)
  • 27
    • 78650746290 scopus 로고    scopus 로고
    • Costs to achieve undetectable HIV RNA with darunavir-containing highly active antiretroviral therapy in highly pretreated patients: The POWER experience
    • Hill AM, Clotet B, JohnstonM, et al. Costs to achieve undetectable HIV RNA with darunavir-containing highly active antiretroviral therapy in highly pretreated patients: The POWER experience. PharmacoEconomics 2010; 28 Suppl. 1: 69-81
    • (2010) PharmacoEconomics , vol.28 , Issue.SUPPL. 1 , pp. 69-81
    • Hill, A.M.1    Clotet B, Johnston.M.2
  • 28
    • 0023716933 scopus 로고
    • Missing data in longitudinal studies
    • Laird NM. Missing data in longitudinal studies. Stat Med 1988; 7: 305-15
    • (1988) Stat Med , vol.7 , pp. 305-15
    • Laird, N.M.1
  • 29
    • 78650724458 scopus 로고    scopus 로고
    • US Department of Labor - Bureau of Labor Statistics. Consumer Price Indexes; [online]. Available from URL: Accessed Dec 10]
    • US Department of Labor - Bureau of Labor Statistics. Consumer Price Indexes; [online]. Available from URL: Http://www.bls.gov/cpi/[Accessed 2009 Dec 10]
    • (2009)
  • 30
    • 0029914863 scopus 로고    scopus 로고
    • The economic costs of caring for people with HIV infection and AIDS in England and Wales
    • Petrou S, Dooley M, Whitaker L, et al. The economic costs of caring for people with HIV infection and AIDS in England and Wales. PharmacoEconomics 1996; 9: 332-40
    • (1996) PharmacoEconomics , vol.9 , pp. 332-40
    • Petrou, S.1    Dooley, M.2    Whitaker, L.3
  • 31
    • 42149127173 scopus 로고    scopus 로고
    • Personal Social Services Research Unit, University of Kent, Canterbury, UK 2005 [online]. Available from URL: [Accessed 2009 Dec 10]
    • Curtis L, Netten A. Unit costs of health and social care 2005. Personal Social Services Research Unit, University of Kent, Canterbury, UK; 2005 [online]. Available from URL: Http://www.pssru.ac.uk/pdf/uc/uc2005/uc2005.pdf [Accessed 2009 Dec 10]
    • (2005) Unit Costs of Health and Social Care
    • Curtis, L.1    Netten, A.2
  • 32
    • 78650750441 scopus 로고    scopus 로고
    • Cost of care for HIV/AIDS in Belgium according to disease stage [abstract P19.5/01]
    • Oct 24-27; Madrid, Spain
    • Caekelbergh K, Moeremans K, Annemans L, et al. Cost of care for HIV/AIDS in Belgium according to disease stage [abstract P19.5/01]. 11th European AIDS Conference; 2007 Oct 24-27; Madrid, Spain
    • (2007) 11th European AIDS Conference
    • Caekelbergh, K.1    Moeremans, K.2    Annemans, L.3
  • 33
    • 78650732369 scopus 로고    scopus 로고
    • Medical resource use and cost of HIV-related care in the HAART-era at a university clinic in Sweden. [abstract P19.10/01]
    • Oct 24-27;Madrid, Spain
    • Ghatnekar O, Gisslén M, Hjortsberg C, et al. Medical resource use and cost of HIV-related care in the HAART-era at a university clinic in Sweden. [abstract P19.10/01]. 11th European AIDS Conference; 2007 Oct 24-27;Madrid, Spain
    • (2007) 11th European AIDS Conference
    • Ghatnekar, O.1    Gisslén, M.2    Hjortsberg, C.3
  • 34
    • 0442291754 scopus 로고    scopus 로고
    • Amulticentre study of patient survival, disability, quality of life and cost of care: Among patients with AIDS in northern Italy
    • Tramarin A, Campostrini S, PostmaMJ, et al. Amulticentre study of patient survival, disability, quality of life and cost of care: Among patients with AIDS in northern Italy. PharmacoEconomics 2004; 22: 43-53
    • (2004) PharmacoEconomics , vol.22 , pp. 43-53
    • Tramarin, A.1    Campostrini, S.2    Postma, M.J.3
  • 35
    • 84920291957 scopus 로고
    • Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults; 1992 Dec 18 [online]. Available from URL [Accessed 2009 Dec 10]
    • Centers for Disease Control and Prevention (CDC). 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults; 1992 Dec 18 [online]. Available from URL: Http://www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm [Accessed 2009 Dec 10]
    • (1993) Centers for Disease Control and Prevention (CDC)
  • 36
    • 78650729866 scopus 로고    scopus 로고
    • Istituto Nazionale di Statistica (INS). Indici dei prezzi al consumo. Periodo di riferimento: November; [online]. Available from URL: [Accessed 2009 Dec 10
    • Istituto Nazionale di Statistica (INS). Indici dei prezzi al consumo. Periodo di riferimento: November; 2006 [online]. Available from URL: Http://www.istat.it [Accessed 2009 Dec 10]
    • (2006)
  • 37
    • 33846017420 scopus 로고    scopus 로고
    • TMC114 provides durable viral load suppression in treatmentexperienced patients: POWER 1 and 2 combined week 48 analysis [abstract TUAB0104]
    • Aug 13-18; Toronto, Canada
    • Lazzarin A, Queiroz-Telles F, Frank I, et al. TMC114 provides durable viral load suppression in treatmentexperienced patients: POWER 1 and 2 combined week 48 analysis [abstract TUAB0104]. 16th International AIDS Conference; 2006 Aug 13-18; Toronto, Canada
    • (2006) 16th International AIDS Conference
    • Lazzarin, A.1    Queiroz-Telles, F.2    Frank, I.3
  • 39
    • 19644365063 scopus 로고    scopus 로고
    • An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002
    • Moore RD, Keruly JC, Gebo KA, et al. An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002. J Acquir Immune Defic Syndr 2005; 39: 195-8
    • (2005) J Acquir Immune Defic Synd , vol.39 , pp. 195-8
    • Moore, R.D.1    Keruly, J.C.2    Gebo, K.A.3
  • 40
    • 3042740596 scopus 로고    scopus 로고
    • Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
    • Ledergerber B, Lundgren JD,Walker AS, et al. Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet 2004; 364: 51-62
    • (2004) Lancet , vol.364 , pp. 51-62
    • Ledergerber, B.1    Lundgren, J.D.2    Walker, A.S.3
  • 41
    • 78650734919 scopus 로고    scopus 로고
    • Efficacy of darunavir/ritonavir in treatment-experienced HIV-1-infected patients at 96 weeks in the POWER 1 and 2 trials [abstract P7.2/07]
    • Oct 24-27; Madrid, Spain
    • Pozniak A, Jayaweera D, Hoy J, et al. Efficacy of darunavir/ritonavir in treatment-experienced HIV-1-infected patients at 96 weeks in the POWER 1 and 2 trials [abstract P7.2/07]. 11th EACS Conference; 2007 Oct 24-27; Madrid, Spain
    • (2007) 11th EACS Conference
    • Pozniak, A.1    Jayaweera, D.2    Hoy, J.3
  • 43
    • 33845459292 scopus 로고    scopus 로고
    • How do we evaluate the economics of health care?
    • Kumar S, Williams AC, Sandy JR. How do we evaluate the economics of health care? Eur J Orthod 2006; 28: 513-9
    • (2006) Eur J Orthod , vol.28 , pp. 513-9
    • Kumar, S.1    Williams, A.C.2    Sandy, J.R.3
  • 44
    • 34347329093 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
    • Madruga JV, Berger D, McMurchie M, et al. Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial. Lancet 2007; 370: 49-58
    • (2007) Lancet , vol.370 , pp. 49-58
    • Madruga, J.V.1    Berger, D.2    McMurchie, M.3
  • 45
    • 7344250683 scopus 로고    scopus 로고
    • The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection
    • Cozzi Lepri A, Katzenstein TL, Ullum H, et al. The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection. AIDS 1998; 12: 1639-43
    • (1998) AIDS , vol.12 , pp. 1639-43
    • Cozzi Lepri, A.1    Katzenstein, T.L.2    Ullum, H.3
  • 46
    • 42049111688 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir/ritonavir versus lopinavir/ritonavir in ARV treatment naive HIV-1 infected patients at Week 48: ARTEMIS [abstract H-718b]
    • Sep 17-20; Chicago, IL, USA
    • DeJesus E, Ortiz R, Khanlou H, et al. Efficacy and safety of darunavir/ritonavir versus lopinavir/ritonavir in ARV treatment naive HIV-1 infected patients at Week 48: ARTEMIS [abstract H-718b]. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy; 2007 Sep 17-20; Chicago, IL, USA
    • (2007) 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • DeJesus, E.1    Ortiz, R.2    Khanlou, H.3
  • 47
    • 55249097136 scopus 로고    scopus 로고
    • Efficacy of once-daily darunavir/ritonavir 800/100 mg in HIV-infected, treatment-experienced patients with no baseline resistance-associated mutations to darunavir
    • De Meyer SM, Spinosa-Guzman S, Vangeneugden TJ, et al. Efficacy of once-daily darunavir/ritonavir 800/100 mg in HIV-infected, treatment-experienced patients with no baseline resistance-associated mutations to darunavir. J Acquir Immune Defic Syndr 2008; 49: 179-82
    • (2008) J Acquir Immune Defic Syndr , vol.49 , pp. 179-82
    • De Meyer, S.M.1    Spinosa-Guzman, S.2    Vangeneugden, T.J.3


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