Evaluation of wound healing potential of calotropis igantea latex studied on excision wounds in experimental rats

Medicinal Chemistry Research

Volumn 19, Issue 8, 2010, Pages 936-947

  Saratha, V ^a   Subramanian, S ^a   Sivakumar, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Calotropis gigantea; Excision wound; Hydroxyproline; Latex; Wound healing

Indexed keywords

CALOTROPIS GIGANTEA LATEX; COLLAGEN; DNA; FLAVONOID; GLYCOSIDE; HEXOSAMINE; HYDROXYPROLINE; NITROFURAL; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN; RNA; TRITERPENOID; UNCLASSIFIED DRUG; URONIC ACID; WOUND HEALING PROMOTING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALOTROPIS GIGANTEA; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; EXPERIMENTAL MODEL; GRANULATION TISSUE; MALE; MEDICINAL PLANT; NONHUMAN; OINTMENT; RAT; TISSUE LEVEL; WOUND CONTRACTION; WOUND HEALING;

EID: 78650719297     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9240-6     Document Type: Article

References (40)

1. Adamsons RJ, Musco F, Enquist IF (1964) The relationship of collagen content to wound strength in normal and scorbutic animals. Surg Gynecol Obstet 119:323-329
2. Alam M, Habib M, Nikkon R, Rahman M, Karim M (2008) Antimicrobial activity of Akanda (Calotropis gigantea L.) on some pathogenic bacteria. Bangladesh J Sci Ind Res 43:397-404
3. Almog R, Shirey TL (1978) A modified orcinol test for the specific determination of RNA. Anal Biochem 91:130-137
4. Atal CK, Sethi PO (1962) Proteolytic activities of some Indian plants. Part III. Pharmacological evaluation of Calotropain. Ind J Pharm 24:131-134
5. Aworh OC, Kasche V, Apampa OO (1994) Purification and some properties of sodom-apple latex proteinases. Food Chem 50:359-362
6. Badwi EL, Samia MA, Adam SE, Shigidi MT, Hapke HJ (1998) Studies on laticiferous plants: toxic effects in goats of Calotropis procera latex given by different routes of administration. Dtsch Tierarztl Wochenschr 105:425-427
7. Balakrishnan B, Mohanty M, Fernandez AC, Mohanan PV, Jayakrishnan A (2006) Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials 27:1355-1361
8. Bardsley WG, Sattar A, Armstrong JR, Shah M, Brosnan P, Ferguson MW (1995) Quantitative analysis of wound healing. Wound Repair Regen 3:426-441
9. Bitter T, Muir HM (1962) A modified uronic acid carbazole reaction. Anal Biochem 4:330-334
10. Broughton G 2nd, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117:12S-34S
11. Burton K (1966) Isolation of certain oligonucleotides obtained by degradation of deoxyribonucleic acid. Biochem J 98:68-69
12. Diegelmann RF, Evans MC (2004) Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 9:283-289
13. Diwan PV, Tilloo LD, Kulkarni DR (1982) Influence of Tridax procumbens on wound healing. Indian J Med Res 75:460-464
14. Duerden BI (1994) Virulence factors in anaerobes. Clin Infect Dis 8(Suppl 4):S253-S259
15. Dunphy JE, Udupa KN (1955) Chemical and histochemical sequences in the normal healing of wounds. N Eng J Med 253:847-851
16. Dunphy JE, Edwards LC, Udupa KN (1956) Wound healing; a new perspective with particular reference to ascorbic acid deficiency. Ann Surg 144:304-317
17. Gardner DG (1967) The relationship of hexosamine and hydroxyproline to connective tissue generation. A review of the literature. J Oral Ther Pharmacol 3:473-484
18. Harish BG, Krishna V, Santosh Kumar HS, Khadeer Ahamed BM, Sharath R, Kumara Swamy HM (2008) Wound healing activity and docking of glycogen-synthase-kinase-3-beta-protein with isolated triterpenoid lupeol in rats. Phytomedicine 15:763-767
19. Kareem SO, Akpan I, Osho MB (2003) Calotropis procera (Sodom apple)-a potential material for enzyme purification. Bioresour Technol 87:133-135
20. Kerstein MD (1997) The scientific basis of healing. Adv Wound Care 10:30-36
21. Li J, Chen J, Kirsner R (2007) Pathophysiology of acute wound healing. Clin Dermatol 25:9-18
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
23. Mascolo N, Sharma R, Jain SC, Capasso F (1988) Ethnopharmacology of Calotropis procera flowers. J Ethnopharmacol 22:211-221
24. Meyer-Ingold W (1993) Wound therapy: growth factors as agents to promote healing. Trends Biotechnol 11:387-392
25. Morton JJ, Malone MH (1972) Evaluation of vulneray activity by an open wound procedure in rats. Arch Int Pharmacodyn Ther 196:117-126
26. Neuman RE, Logan MA (1950) The determination of collagen and elastin in tissues. J Biol Chem 186:549-556
27. Perez Gutierrez RM, Vargas SR (2006) Evaluation of the wound healing properties of Acalypha langiana in diabetic rats. Fitoterapia 77:286-289
28. Purna SK, Babu M (2000) Collagen based dressings-a review. Burns 26:54-62
29. Rahman MA, Wilcock CC (1991) A taxonomic revision of Calotropis (Asclepiadaceae). Nord J Bot 11:301-308
30. Ramos MV, Aguiar VC, da Silva Xavier AA, Lima MW, Bandeira GP, Etchells JP, Nogueira NA, Alencar NM (2006) Latex proteins from the plant Calotropis procera are partially digested upon in vitro enzymatic action and are not immunologically detected in fecal material. Fitoterapia 77:251-256
31. Rasik AM, Raghubir R, Gupta A, Shukla A, Dubey MP, Srivastava S, Jain HK, Kulshrestha DK (1999),Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacol 68:261-266.
32. Sen S, Sahu NP, Mahato SB (1992) Flavonol glycosides from Calotropis gigantea. Phytochemistry 31:2919-2921
33. Shilpkar P, Mayur S, Chaudhary DR (2007) An alternate use of Calotropis gigantea: Biomethanation. Curr Sci 92:435-437
34. Shoshan S, Gross J (1974) Biosynthesis and metabolism of collagen and its role in tissue repair processes. Isr J Med Sci 10:537-561
35. Singh H, Kumar S, Dewan S, Kumar VL (2000) Inflammation induced by latex of Calotropis procera-a new model to evaluate anti-inflammatory drugs. J Pharmacol Toxicol Methods 43:219-224
36. Subramanian S, Sathish Kumar D, Arulselvan P (2006) Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J Biochem 1:178-185
37. Whitney JD (2005) Overview: acute and chronic wounds. Nurs Clin North Am 40:191-205
38. WHO (2000) General guidelines for methodologies on research and evaluation of traditional medicine. Geneva, Switzerland WHO/EDM/TRM/2000.1, pp 1-80
39. Woessner JF Jr (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93:440-447
40. Xu J, Clark RA (1996) Extracellular matrix alters PDGF regulation of fibroblast integrins. J Cell Biol 132:239-249