Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 448-457

  Ferlin, Maria Grazia ^a   Conconi, Maria Teresa ^a   Urbani, Luca ^a   Oselladore, Barbara ^a   Guidolin, Diego ^a   Di Liddo, Rosa ^a   Parnigotto, Pier Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Angiogenesis; Anti vascular agents; Phenyl pyrroloquinolinones; Pyrroloazaflavones

Indexed keywords

3 (4 OXO 2 PHENYL 1,4 DIHYDRO PYRROLO[2,3 H]QUINOLIN 7 PROPIONIC ACID ETHYL ESTER; 7 CYCLOPROPYLMETHYL 2 PHENYL 1H,7H PYRROLO[2,3 H)QUINOLIN 4 ONE; 7 ETHYL 2 PHENYL 1H,7H PYRROLO[2,3 H]QUINOLIN 4 ONE; 8 METHYL 2 PHENYL 1H,7H PYRROLO[2,3 H]QUINOLIN 4 ONE; FIBROBLAST GROWTH FACTOR 2; FLAVONE DERIVATIVE; MATRIGEL; UNCLASSIFIED DRUG; VINBLASTINE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; CAPILLARY; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CONCENTRATION (PARAMETERS); DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MORPHOGENESIS; MOUSE; NONHUMAN; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; AZA COMPOUNDS; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FLAVONES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 78650718771     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.010     Document Type: Article

References (20)

1. F. Donate Drugs Future 30 2005 695
2. D.W. Siemann, M.C. Bibby, G.G. Dark, A.P. Dicker, F.A.L.M. Esken, M.R. Horsman, D. Maerm, and P.M. LoRusso Clin. Cancer Res. 11 2005 416
3. J.W. Lippert Bioorg. Med. Chem. 15 2007 605
4. P. Mabeta, and M.S. Pepper Angiogenesis 12 2009 81
5. C. Kanthou, and G.M. Tozer Int. J. Exp. Pathol. 90 2009 284
6. M.G. Ferlin, G. Chiarelotto, V. Gasparotto, L. Barzon, G. Palu', and I. Castagliuolo J. Med. Chem. 48 2005 3417
7. V. Gasparotto, I. Castagliuolo, G. Chiarelotto, V. Pezzi, G. Montanaro, P. Brun, G. Palu, and M.G. Ferlin J. Med. Chem. 49 2006 1910
8. V. Gasparotto, I. Castagliuolo, and M.G. Ferlin J. Med. Chem. 50 2007 5509
9. J. Bergman, and P. Sand Org. Synth. 65 1987 146
10. J. Bergman, P. Sand, and U. Tilstam Tetrahedron Lett. 24 1983 3665
11. A. Vacca, M. Lurlalo, D. Ribatti, M. Minischetti, B. Nico, R. Ria, A. Pellegrino, and F. Dammacco Blood 94 1999 4143
12. Folkman J. Cancer Biol. 13 2003 159
13. D. Ribatti, D. Marimpietri, F. Pastorino, C. Brignole, B. Nico, A. Vacca, and M. Ponzoni Ann. N.Y. Acad. Sci. 1028 2004 133
14. E.L. Schwartz Clin. Cancer Res. 15 2009 2594
15. D. Belotti, V. Vergani, T. Drudis, P. Borsotti, R. Pitelli, G. Viale, R. Giavazzi, and G. Taraboletti Clin. Cancer Res. 2 1996 1843
16. C. Kanthou, and G.M. Tozer Blood 99 2002 2060
17. T.J. Kim, M. Ravoori, C.N. Landen, A.A. Kamat, L.Y. Han, C. Lu, Y.G. Lin, W.M. Merrit, N. Jennings, W.A. Spannuth, R. Langley, D.M. Gershenson, R.L. Coleman, V. Kundra, and A.K. Sood Cancer Res. 67 2007 9337
18. N. Klauber, S. Parangi, E. Flynn, E. Hamel, and R.J. D'Amato Cancer Res. 57 1997 81
19. C. Malcontenti-Wilson, L. Chan, M. Nikfarian, V. Muralidharan, and C. Christophy J. Gastroenterol. Hepatol. 23 2008 c96
20. G. Micheletti, M. Poli, P. Borsotti, M. Martinelli, B. Imberti, G. Taraboletti, and R. Giavazzi Cancer Res. 63 2003 1534