A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury

Journal of Pain

Volumn 12, Issue 1, 2011, Pages 94-100

  Hayashida, Ken Ichiro ^a   Eisenach, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

cholinergic; K252a; Neuropathic pain; noradrenergic; spinal cord; tyrosine kinase receptor

Indexed keywords

ACETYLCHOLINE; ALPHA 2 ADRENERGIC RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CLONIDINE; DEXMEDETOMIDINE; DOPAMINE BETA MONOOXYGENASE; GABAPENTIN; K 252A; PHOSPHOTRANSFERASE; POTASSIUM CHLORIDE; TROPOMYOSINE RECEPTOR KINASE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; FACILITATION; IMMUNOREACTIVITY; MALE; NERVE CELL PLASTICITY; NERVE FIBER; NERVE LIGATION; NEUROANATOMY; NONHUMAN; NORADRENERGIC SYSTEM; PERIPHERAL NERVE INJURY; RAT; SIGNAL TRANSDUCTION; SYNAPTOSOME;

ACETYLCHOLINE; AMINES; ANALGESICS; ANIMALS; CARBAZOLES; CHOLINE O-ACETYLTRANSFERASE; CLONIDINE; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOPAMINE BETA-HYDROXYLASE; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; INDOLE ALKALOIDS; MALE; NEURALGIA; NEURONAL PLASTICITY; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES; SYNAPTOSOMES; TIME FACTORS;

EID: 78650713943     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.05.005     Document Type: Article

References (35)

1. C. Bantel, J.C. Eisenach, F. Duflo, J.R. Tobin, and S.R. Childers Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord Brain Res 1038 2005 76 82
2. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1994 55 63
3. J.A. Coull, S. Beggs, D. Boudreau, D. Boivin, M. Tsuda, K. Inoue, C. Gravel, M.W. Salter, and Y. De Koninck BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain Nature 438 2005 1017 1021
4. M.G. Eason, H. Kurose, B.D. Holt, J.R. Raymond, and S.B. Liggett Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs J Biol Chem 267 1992 15795 15801
5. J.C. Eisenach Muscarinic-mediated analgesia Life Sci 64 1999 549 554
6. J.C. Eisenach, S. DuPen, M. Dubois, R. Miguel, and D. Allin Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group Pain 61 1995 391 399
7. T. Fukuoka, E. Kondo, Y. Dai, N. Hashimoto, and K. Noguchi Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model J Neurosci 21 2001 4891 4900
8. A. Gal, E. Ducza, R. Minorics, A. Klukovits, M. Galik, G. Falkay, and R. Gaspar The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat Eur J Pharmacol 615 2009 193 200
9. K. Hayashida, S. DeGoes, R. Curry, and J.C. Eisenach Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery Anesthesiology 106 2007 557 562
10. K. Hayashida, and J.C. Eisenach Spinal α2-adrenoceptor mediated analgesia in neuropathic pain reflects brain derived nerve growth factor and changes in spinal cholinergic neuronal function Anesthesiology 113 2010 406 412
11. K. Hayashida, H. Obata, K. Nakajima, and J.C. Eisenach Gabapentin acts within the locus coeruleus to alleviate neuropathic pain Anesthesiology 109 2008 1077 1084
12. K. Hayashida, R. Parker, and J.C. Eisenach Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil Anesthesiology 106 2007 1213 1219
13. K.I. Hayashida, T. Bynum, M. Vincler, and J.C. Eisenach Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury Neuroscience 140 2006 259 268
14. K.I. Hayashida, B.A. Clayton, J.E. Johnson, and J.C. Eisenach Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats Pain 136 2008 348 355
15. L.B. Jakeman, P. Wei, Z. Guan, and B.T. Stokes Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury Exp Neurol 154 1998 170 184
16. R.S. Jope Acetylcholine turnover and compartmentation in rat brain synaptosomes J Neurochem 36 1981 1712 1721
17. S.H. Kim, and J.M. Chung An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 1992 355 363
18. V.R. King, G.J. Michael, R.K. Joshi, and J.V. Priestley trkA, trkB, and trkC messenger RNA expression by bulbospinal cells of the rat Neuroscience 92 1999 935 944
19. A. Merighi, C. Salio, A. Ghirri, L. Lossi, F. Ferrini, C. Betelli, and R. Bardoni BDNF as a pain modulator Prog Neurobiol 85 2008 297 317
20. M.J. Millan Descending control of pain Prog Neurobiol 66 2002 355 474
21. H. Obata, X. Li, and J.C. Eisenach alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats Anesthesiology 102 2005 657 662
22. H. Obata, S. Saito, S. Koizuka, K. Nishikawa, and F. Goto The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain Anesth Analg 100 2005 1406 1410 table of contents
23. H.L. Pan, S.R. Chen, and J.C. Eisenach Intrathecal clonidine alleviates allodynia in neuropathic rats: Interaction with spinal muscarinic and nicotinic receptors Anesthesiology 90 1999 509 514
24. H.L. Pan, Z.Z. Wu, H.Y. Zhou, S.R. Chen, H.M. Zhang, and D.P. Li Modulation of pain transmission by G-protein-coupled receptors Pharmacol Ther 117 2008 141 161
25. X. Paqueron, D. Conklin, and J.C. Eisenach Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury Anesthesiology 99 2003 199 204
26. X. Paqueron, X. Li, and J.C. Eisenach P75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine Neuroscience 102 2001 681 686
27. Z. Pittel, S. Cohen, A. Fisher, and E. Heldman Differential long-term effect of AF64A on [3H]ACh synthesis and release in rat hippocampal synaptosomes Brain Res 586 1992 148 151
28. M. Rowbotham, N. Harden, B. Stacey, P. Bernstein, and L. Magnus-Miller Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial JAMA 280 1998 1837 1842
29. H. Shen, J.M. Chung, and K. Chung Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury Brain Res Mol Brain Res 64 1999 186 1892
30. M. Sonohata, H. Furue, T. Katafuchi, T. Yasaka, A. Doi, E. Kumamoto, and M. Yoshimura Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording J Physiol 555 2004 515 526
31. B. Sung, G. Lim, and J. Mao Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats J Neurosci 23 2003 2899 2910
32. K. Takasu, M. Honda, H. Ono, and M. Tanabe Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury Br J Pharmacol 148 2006 233 244
33. M.H. Tuszynski, E. Mafong, and S. Meyer Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons Neuroscience 71 1996 761 771
34. K. Xu, K. Uchida, H. Nakajima, S. Kobayashi, and H. Baba Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression Spine 31 2006 1867 1874
35. T.L. Yaksh, and T.A. Rudy Chronic catheterization of the spinal subarachnoid space Physiol Behav 17 1976 1031 1036