메뉴 건너뛰기




Volumn 11, Issue 3, 2010, Pages 661-667

Comparison of protective effects of L-carnitine and amifostine on radiation-induced toxicity to growing bone: Histopathology and scintigraphy findings

Author keywords

Amifostine; Growing bone; Irradiation; L carnitine; Radioprotection

Indexed keywords


EID: 78650691458     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (42)
  • 1
    • 0031750868 scopus 로고    scopus 로고
    • Fractionation effect on radiation-induced growth retardation of tibia in rabbits and rats
    • Alheit H, Baumann M, Thames HD, (1998). Fractionation effect on radiation-induced growth retardation of tibia in rabbits and rats. Acta Oncol, 37, 151-8.
    • (1998) Acta Oncol , vol.37 , pp. 151-158
    • Alheit, H.1    Baumann, M.2    Thames, H.D.3
  • 2
    • 33748277838 scopus 로고    scopus 로고
    • L-carnitine reduces cochlear damage induced by gamma irradiation in Guinea pigs
    • Altas E, Ertekin MV, Gundogdu C, et al. (2006). L-carnitine reduces cochlear damage induced by gamma irradiation in Guinea pigs. Ann Clin Lab Sci, 36, 312-8.
    • (2006) Ann Clin Lab Sci , vol.36 , pp. 312-318
    • Altas, E.1    Ertekin, M.V.2    Gundogdu, C.3
  • 3
    • 0037268373 scopus 로고    scopus 로고
    • Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy
    • Andreassen CN, Grau C, Lindegaard JC. (2003). Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy. Semin Radiat Oncol, 13, 62-72.
    • (2003) Semin Radiat Oncol , vol.13 , pp. 62-72
    • Andreassen, C.N.1    Grau, C.2    Lindegaard, J.C.3
  • 4
    • 0034888083 scopus 로고    scopus 로고
    • L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment
    • Athanassakis I, Mouratidou M, Sakka P, et al. (2001). L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment. Int Immunopharmacol, 1, 1813-22.
    • (2001) Int Immunopharmacol , vol.1 , pp. 1813-1822
    • Athanassakis, I.1    Mouratidou, M.2    Sakka, P.3
  • 5
    • 0034880632 scopus 로고    scopus 로고
    • Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial
    • Benvenga S, Ruggeri RM, Russo A, et al. (2001). Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab, 86, 3579-94.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3579-3594
    • Benvenga, S.1    Ruggeri, R.M.2    Russo, A.3
  • 6
    • 10644275844 scopus 로고    scopus 로고
    • Effects of carnitine on thyroid hormone action
    • Benvenga S, Amato A, Calvani M, et al. (2004). Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci, 1033, 158-67.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 158-167
    • Benvenga, S.1    Amato, A.2    Calvani, M.3
  • 7
    • 0028051497 scopus 로고
    • L-propionyl carnitine protects erythrocytes and low density lipoproteins against peroxidation
    • Bertelli A, Conte A, Ronca G. (1994). L-propionyl carnitine protects erythrocytes and low density lipoproteins against peroxidation. Drugs Exp Clin Res, 20, 191-7.
    • (1994) Drugs Exp Clin Res , vol.20 , pp. 191-197
    • Bertelli, A.1    Conte, A.2    Ronca, G.3
  • 8
    • 65349172318 scopus 로고    scopus 로고
    • The histopathologic and scintigraphic comparison of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats
    • Caloglu M, V. Yurut-Caloglu, G. Durmus-Altun, et al. (2009). The histopathologic and scintigraphic comparison of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats. Clin Exp Pharmacol Physiol, 36, 523-30.
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. 523-530
    • Caloglu, M.1    Yurut-Caloglu, V.2    Durmus-Altun, G.3
  • 9
    • 23944474304 scopus 로고    scopus 로고
    • L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro
    • Colucci S, Mori G, Vaira S, et al. (2005). L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro. Calcif Tissue Int, 76, 458-65.
    • (2005) Calcif Tissue Int , vol.76 , pp. 458-465
    • Colucci, S.1    Mori, G.2    Vaira, S.3
  • 10
    • 0034237281 scopus 로고    scopus 로고
    • Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment
    • Damron TA, Spadaro JA, Tamurian RM, et al. (2000). Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment. Int J Radiat Oncol Biol Phys, 47, 1067-71.
    • (2000) Int J Radiat Oncol Biol Phys , vol.47 , pp. 1067-1071
    • Damron, T.A.1    Spadaro, J.A.2    Tamurian, R.M.3
  • 11
    • 0035370688 scopus 로고    scopus 로고
    • Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone
    • Damron TA, Margulies B, Biskup D, et al. (2001). Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone. Int J Radiat Oncol Biol Phys, 50, 479-83.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 479-483
    • Damron, T.A.1    Margulies, B.2    Biskup, D.3
  • 12
    • 0037786552 scopus 로고    scopus 로고
    • Sequential histomorphometric analysis of the growth plate following irradiation with and without radioprotection
    • Damron TA, Margulies BS, Strauss JA, et al. (2003). Sequential histomorphometric analysis of the growth plate following irradiation with and without radioprotection. J Bone Joint Surg Am, 85, 1302-13.
    • (2003) J Bone Joint Surg Am , vol.85 , pp. 1302-1313
    • Damron, T.A.1    Margulies, B.S.2    Strauss, J.A.3
  • 13
    • 4444317262 scopus 로고    scopus 로고
    • Combinations of radioprotectants spare radiation-induced damage to the physis
    • Damron TA, Spadaro JA, Horton JA, et al. (2004). Combinations of radioprotectants spare radiation-induced damage to the physis. Clin Orthop Relat Res, 110-6.
    • (2004) Clin Orthop Relat Res , pp. 110-116
    • Damron, T.A.1    Spadaro, J.A.2    Horton, J.A.3
  • 14
    • 0025162630 scopus 로고
    • Radiation fractionation sensitivity of epiphyseal cartilage in a weanling rat model
    • Eifel PJ, Sampson CM, Tucker SL. (1990). Radiation fractionation sensitivity of epiphyseal cartilage in a weanling rat model. Int J Radiat Oncol Biol Phys, 19, 661-4.
    • (1990) Int J Radiat Oncol Biol Phys , vol.19 , pp. 661-664
    • Eifel, P.J.1    Sampson, C.M.2    Tucker, S.L.3
  • 15
    • 0036534209 scopus 로고    scopus 로고
    • Efficacy of radioprotection in the prevention of radiation-induced craniofacial bone growth inhibition
    • Forrest CR, O'Donovan DA, Yeung I, et al. (2002). Efficacy of radioprotection in the prevention of radiation-induced craniofacial bone growth inhibition. Plast Reconstr Surg, 109, 1311-23.
    • (2002) Plast Reconstr Surg , vol.109 , pp. 1311-1323
    • Forrest, C.R.1    O'Donovan, D.A.2    Yeung, I.3
  • 16
    • 0027453676 scopus 로고
    • Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes
    • Fritz IB, Arrigoni-Martelli E. (1993). Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes. Trends Pharmacol Sci, 14, 355-60.
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 355-360
    • Fritz, I.B.1    Arrigoni-Martelli, E.2
  • 17
    • 53149095437 scopus 로고    scopus 로고
    • Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells
    • Gevorgyan A, Sukhu B, Alman BA, et al. (2008). Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells. Plast Reconstr Surg, 122, 1025-35.
    • (2008) Plast Reconstr Surg , vol.122 , pp. 1025-1035
    • Gevorgyan, A.1    Sukhu, B.2    Alman, B.A.3
  • 18
    • 0026034165 scopus 로고
    • Effects of radiation therapy on skeletal growth in childhood
    • Goldwein JW. (1991). Effects of radiation therapy on skeletal growth in childhood. Clin Orthop Relat Res, 101-107.
    • (1991) Clin Orthop Relat Res , pp. 101-107
    • Goldwein, J.W.1
  • 19
    • 0037133304 scopus 로고    scopus 로고
    • Feeding acetyl-Lcarnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
    • Hagen TM, Liu J, Lykkesfeldt J, et al. (2002). Feeding acetyl-Lcarnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A, 99, 1870-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1870-1875
    • Hagen, T.M.1    Liu, J.2    Lykkesfeldt, J.3
  • 20
    • 46049088291 scopus 로고    scopus 로고
    • Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats
    • Hooshmand S, Balakrishnan A, Clark RM, et al. (2008). Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Phytomedicine, 15, 595-601.
    • (2008) Phytomedicine , vol.15 , pp. 595-601
    • Hooshmand, S.1    Balakrishnan, A.2    Clark, R.M.3
  • 21
    • 56549091749 scopus 로고    scopus 로고
    • Amifostine use in radiation-induced kidney damage. Preclinical evaluation with scintigraphic and histopathologic parameters
    • Kaldir M, Cosar-Alas R, Cermik TF, et al. (2008). Amifostine use in radiation-induced kidney damage. Preclinical evaluation with scintigraphic and histopathologic parameters. Strahlenther Onkol, 184, 370-5.
    • (2008) Strahlenther Onkol , vol.184 , pp. 370-375
    • Kaldir, M.1    Cosar-Alas, R.2    Cermik, T.F.3
  • 23
    • 33947578985 scopus 로고    scopus 로고
    • The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model
    • Kocer I, Taysi S, Ertekin MV, et al. (2007). The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. Graefes Arch Clin Exp Ophthalmol, 245, 588-94.
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , pp. 588-594
    • Kocer, I.1    Taysi, S.2    Ertekin, M.V.3
  • 24
    • 3042651070 scopus 로고    scopus 로고
    • Impact on cytoprotective efficacy of intermediate interval between amifostine administration and radiotherapy: a retrospective analysis
    • Kouloulias VE, Kouvaris JR, Kokakis JD, et al. (2004). Impact on cytoprotective efficacy of intermediate interval between amifostine administration and radiotherapy: a retrospective analysis. Int J Radiat Oncol Biol Phys, 59, 1148-56.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 1148-1156
    • Kouloulias, V.E.1    Kouvaris, J.R.2    Kokakis, J.D.3
  • 25
    • 33746363249 scopus 로고    scopus 로고
    • Protective role of carnitine ester against radiation-induced oxidative stress in rats
    • Mansour HH. (2006). Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res, 54, 165-71.
    • (2006) Pharmacol Res , vol.54 , pp. 165-171
    • Mansour, H.H.1
  • 26
    • 55449096698 scopus 로고    scopus 로고
    • The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro
    • Margulies BS, Damron TA, Allen MJ. (2008). The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro. J Orthop Res, 26, 1512-9.
    • (2008) J Orthop Res , vol.26 , pp. 1512-1519
    • Margulies, B.S.1    Damron, T.A.2    Allen, M.J.3
  • 27
    • 41049087389 scopus 로고    scopus 로고
    • L: -carnitine fumarate and isovaleryl-L: -carnitine fumarate accelerate the recovery of bone volume/total volume ratio after experimetally induced osteoporosis in pregnant mice
    • Patano N, Mancini L, Settanni MP, et al. (2008). L: -carnitine fumarate and isovaleryl-L: -carnitine fumarate accelerate the recovery of bone volume/total volume ratio after experimetally induced osteoporosis in pregnant mice. Calcif Tissue Int, 82, 221-8.
    • (2008) Calcif Tissue Int , vol.82 , pp. 221-228
    • Patano, N.1    Mancini, L.2    Settanni, M.P.3
  • 28
    • 4444243001 scopus 로고    scopus 로고
    • Late effects of radiotherapy for pediatric extremity sarcomas
    • Paulino AC. (2004). Late effects of radiotherapy for pediatric extremity sarcomas. Int J Radiat Oncol Biol Phys, 60, 265-74.
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 265-274
    • Paulino, A.C.1
  • 29
    • 0027954494 scopus 로고
    • Free radicals in biology: oxidative stress and the effects of ionizing radiation
    • Riley PA. (1994). Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol, 65, 27-33.
    • (1994) Int J Radiat Biol , vol.65 , pp. 27-33
    • Riley, P.A.1
  • 31
    • 0016424846 scopus 로고
    • The effects of radiation therapy on bone growth
    • Probert JC, Parker BR. (1975). The effects of radiation therapy on bone growth. Radiology, 114, 155-62.
    • (1975) Radiology , vol.114 , pp. 155-162
    • Probert, J.C.1    Parker, B.R.2
  • 33
    • 0037216615 scopus 로고    scopus 로고
    • Effects of irradiation on the appositional and longitudinal growth of the tibia and fibula of the rat with and without radioprotectant
    • Spadaro JA, Baesl MT, Conta AC, et al. (2003). Effects of irradiation on the appositional and longitudinal growth of the tibia and fibula of the rat with and without radioprotectant. J Pediatr Orthop, 23, 35-40.
    • (2003) J Pediatr Orthop , vol.23 , pp. 35-40
    • Spadaro, J.A.1    Baesl, M.T.2    Conta, A.C.3
  • 34
    • 0032933684 scopus 로고    scopus 로고
    • Sparing radiation-induced damage to the physis by radioprotectant drugs: laboratory analysis in a rat model
    • Tamurian RM, Damron TA, Spadaro JA. (1999). Sparing radiation-induced damage to the physis by radioprotectant drugs: laboratory analysis in a rat model. J Orthop Res, 17, 286-92.
    • (1999) J Orthop Res , vol.17 , pp. 286-292
    • Tamurian, R.M.1    Damron, T.A.2    Spadaro, J.A.3
  • 35
    • 33646874555 scopus 로고    scopus 로고
    • Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model
    • Ucuncu H, Ertekin MV, Yoruk O, et al. (2006). Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model. J Radiat Res (Tokyo), 47, 91-102.
    • (2006) J Radiat Res (Tokyo) , vol.47 , pp. 91-102
    • Ucuncu, H.1    Ertekin, M.V.2    Yoruk, O.3
  • 36
    • 4544234075 scopus 로고    scopus 로고
    • The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances
    • Uzal C, Durmus-Altun G, Caloglu M, et al. (2004). The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances. Int J Radiat Oncol Biol Phys, 60, 564-9.
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 564-569
    • Uzal, C.1    Durmus-Altun, G.2    Caloglu, M.3
  • 37
    • 0033938076 scopus 로고    scopus 로고
    • L -propionylcarnitine as superoxide scavenger, antioxidant, and DNA cleavage protector
    • Vanella A, Russo A, Acquaviva R, et al. (2000). L -propionylcarnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol, 16, 99-104.
    • (2000) Cell Biol Toxicol , vol.16 , pp. 99-104
    • Vanella, A.1    Russo, A.2    Acquaviva, R.3
  • 38
    • 0022448418 scopus 로고
    • In vivo and in vitro effects of WR-2721 in experimental hypercalcemia in the rat
    • Weiss J, Walker ST, Fallon M, et al. (1986). In vivo and in vitro effects of WR-2721 in experimental hypercalcemia in the rat. J Pharmacol Exp Ther, 238, 969-73.
    • (1986) J Pharmacol Exp Ther , vol.238 , pp. 969-973
    • Weiss, J.1    Walker, S.T.2    Fallon, M.3
  • 39
  • 40
    • 33746612862 scopus 로고    scopus 로고
    • The effect of X-rays on bone: a pictorial review
    • Williams HJ, Davies AM. (2006). The effect of X-rays on bone: a pictorial review. Eur Radiol, 16, 619-33.
    • (2006) Eur Radiol , vol.16 , pp. 619-633
    • Williams, H.J.1    Davies, A.M.2
  • 41
    • 0021066608 scopus 로고
    • Modification of the radiation response of the mouse kidney by misonidazole and WR-2721
    • Williams MV, Denekamp J. (1983). Modification of the radiation response of the mouse kidney by misonidazole and WR-2721. Int J Radiat Oncol Biol Phys, 9, 1731-6.
    • (1983) Int J Radiat Oncol Biol Phys , vol.9 , pp. 1731-1736
    • Williams, M.V.1    Denekamp, J.2
  • 42
    • 61749099734 scopus 로고    scopus 로고
    • Radioprotection of osteoblasts by a fractionated dose regimen and amifostine
    • Wong AK, Mei L, Soares MA, et al. (2009). Radioprotection of osteoblasts by a fractionated dose regimen and amifostine. Plast Reconstr Surg, 123, 104S-113S.
    • (2009) Plast Reconstr Surg , vol.123
    • Wong, A.K.1    Mei, L.2    Soares, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.