Paraoxonase 1 correlates with butyrylcholinesterase and gamma glutamyl transferase in workers chronically exposed to pesticides

Journal of Occupational Health

Volumn 52, Issue 6, 2010, Pages 383-388

  Araoud, Manel ^a,b   Neffeti, Fadoua ^b   Douki, Wahiba ^b   Najjar, Mohamed Fadhel ^b   Kenani, Abderraouf ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b University Hospital Fattouma Bourguiba Monastir   (Tunisia)

Author keywords

Agricultural workers; Butyrylcholinesterase; Enzymes; Gamma glutamyl transferase; Paraoxonase 1; Pesticides

Indexed keywords

ALKALINE PHOSPHATASE; ARYLDIALKYLPHOSPHATASE; BIOLOGICAL MARKER; CHOLINESTERASE; CREATINE KINASE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; PESTICIDE;

ADOLESCENT; ADULT; AGED; AGRICULTURE; ARTICLE; BLOOD; FEMALE; HUMAN; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; TUNISIA;

ADOLESCENT; ADULT; AGED; AGRICULTURE; ALKALINE PHOSPHATASE; ARYLDIALKYLPHOSPHATASE; BIOLOGICAL MARKERS; BUTYRYLCHOLINESTERASE; CREATINE KINASE; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PESTICIDES; TUNISIA; YOUNG ADULT;

EID: 78650673133     PISSN: 13419145     EISSN: 13489585     Source Type: Journal    
DOI: 10.1539/joh.O10017     Document Type: Article

References (22)

1. Hernandez AF, Amparo GM, Perez V, et al. Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agriculture farmers. Environ Res 2006; 102: 70-6.
2. Hernandez AF, Lopez O, Rodrigo L, et al. Changes in erythrocyte enzymes in humans long-term exposed to pesticides: influence of several markers of individual susceptibility. Toxicol lett 2005; 159: 13-21.
3. Altuntas I, Delibas N, Demirci M, Kilinc I, Tamer N. The effects of methidathion on lipid peroxidation and some liver enzymes: role of vitamin E and C. Arch Toxicol 2002; 76: 470-3.
4. Azmi MA, Naqvi SNH, Azmi MA, Arshad M. Effect of pesticide residues on health and different enzyme levels in the blood of farm workers from Gadap (rural area) Karachi-Pakistan. Chemosphere 2006; 64: 1739-44.
5. Seth V, Banerjee BD, Bhattacharya A, Pasha ST, Chakravorty AK. Pesticide induced alterations in acetylcholine esterase and gamma glutamyl transpeptidase activities and glutathione level in lymphocytes of human poisoning cases. Clin Biochem 2001; 34: 427-9.
6. Banerjee BD, Seth V, Bhattacharya A, Pasha ST, Chakravorty AK. Biochemical effects of some pesticides on lipid peroxidation and free radical scavengers. Toxicol lett 1999; 107: 33-47.
7. Furlong CE, Costa LG, Hassett C, et al. Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. Chem Biol Interact 1993; 87: 35-48.
8. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003; 8: 1-12.
9. Furlong CE, Li WF, Richter RJ, et al. Genetic and temporal determinations of pesticide sensitivity: role of paraoxonase (PON1). Neuro Toxicol 2000; 21: 91-100.
10. Hernandez AF, Gomez MA, Pena G, et al. Effect of longterm exposure to pesticides on plasma esterases from plastic greenhouse workers. J Toxicol Environ Health A 2004; 67: 1095-108.
11. Santanam N, Parthasarathy S. Aspirin is a substrate for paraoxonase-like activity: implications in atherosclerosis. Atherosclerosis 2007; 191: 272-5.
12. Zhou ZJ, Zheng J, Wu QE, Xie F. Carboxylic esterase and its associations with long-term effects of organophosphorus pesticides. Biomed Environ Sci 2007; 20: 284-90.
13. Ranjbar A, Pasalar P, Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition organophosphorous pesticide manufacturing workers. Hum Exp Toxicol 2002; 21: 179-82.
14. Friedman LS, Brautbar N, Barach P, Wolfe AH, Richter ED. Creatine phosphate kinase elevations signaling muscle damage following exposures to anticholinesterases: 2 sentinel patients. Arch Environ Health 2003; 58: 167-71.
15. Michalek JE, Ketchum NS, Longnecker MP. Serum dioxin and hepatic abnormalities in veterans of Operation Ranch Hand. Ann Epidemiol 2001; 11: 304-11.
16. Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chem Biol Interact 1999; 119: 429-38.
17. Furlong, C.E., Li, W.F., Brophy, V.H., et al. The PON1 gene and detoxication. Neuro Toxicol 2000; 21: 581-8.
18. Akgür SA, Oztürk P, Sozmen EY, et al. Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds. J Toxicol Environ Health A 1999; 58: 469-74.
19. Akgür SA, Oztürk P, Solak I, Moral AR, Ege B. Human serum paraoxonase (PON1) activity in acute organophosphorus insecticide poisoning. Forensic Sci Int 2003; 133: 136-40.
20. Benmoyal-Segal L, Tatiana V, Sagiv S, et al. Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. FASEB J 2005; 15: 1-17.
21. Lee DH, Jacobs Jr DR. Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: results from the National Health and Examination Survey 1999-2002. Clin Chem 2006; 52: 1825-7.
22. Lee DH, Gross MD, Steffes MW, Jacobs Jr DR. Is serum gamma-glutamyltransferase a biomarker of xenobiotics, which are conjugated by glutathione? Arterioscler Thromb 2008; 28: 26.