Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes

Journal of Immunology

Volumn 185, Issue 11, 2010, Pages 6985-6998

  Machida, Keigo ^a   Mcnamara, George ^b   Cheng, Kevin T H ^a   Huang, Jeffrey ^a,c   Wang, Chun Hsiang ^a   Comai, Lucio ^a   Ou, Jing Hsiung James ^a   Lai, Michael M C ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c Tainan Munic ipal Hospital   (Taiwan)

^d ACADEMIA SINICA   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BLEOMYCIN; CORE PROTEIN; MRE11 PROTEIN; NIBRIN; NITRIC OXIDE; NONSTRUCTURAL PROTEIN 3; RAD50 PROTEIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; B LYMPHOCYTE; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA REPAIR; EMBRYO; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; LIVER CELL; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SISTER CHROMATID EXCHANGE; VIRUS CORE;

ANIMALS; ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HEK293 CELLS; HEP G2 CELLS; HEPACIVIRUS; HEPATOCYTES; HUMANS; MICE; MICE, TRANSGENIC; MONOCYTES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; VIRAL CORE PROTEINS;

EID: 78650667610     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000618     Document Type: Article

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