메뉴 건너뛰기




Volumn 7, Issue 1, 2011, Pages 11-18

After FRANCIS: Next steps in the clinical evaluation of varespladib methyl

Author keywords

FRANCIS; phospholipase inhibitor; secretory phospholipase A2; varespladib methyl

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; ESTERASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SECRETORY PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; VARESPLADIB METHYL;

EID: 78650633272     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/fca.10.118     Document Type: Article
Times cited : (5)

References (26)
  • 1
    • 77956607620 scopus 로고    scopus 로고
    • Novel therapies affecting the vascular wall
    • Ballantyne CM (Ed.). Saunders Elsevier, PA, USA
    • Rosenson RS. Novel therapies affecting the vascular wall. In: Braunwalds Clinical Lipidology. Ballantyne CM (Ed.). Saunders Elsevier, PA, USA 553-567 (2008).
    • (2008) Braunwalds Clinical Lipidology , pp. 553-567
    • Rosenson, R.S.1
  • 2
    • 77953593684 scopus 로고    scopus 로고
    • Early identification of atherosclerotic disease by noninvasive imaging
    • Fuster V, Lois F, Franco M. Early identification of atherosclerotic disease by noninvasive imaging. Nat. Rev. Cardiol. 7, 327-333 (2010).
    • (2010) Nat. Rev. Cardiol. , vol.7 , pp. 327-333
    • Fuster, V.1    Lois, F.2    Franco, M.3
  • 3
    • 77952692199 scopus 로고    scopus 로고
    • Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography
    • Rudd JHF, Narula J, Strauss W, et al. Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography. J. Am. Coll. Cardiol. 55, 2527-2535 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 2527-2535
    • Jhf, R.1    Narula, J.2    Strauss, W.3
  • 4
    • 27744540257 scopus 로고    scopus 로고
    • Acute-phase reactants and coronary heart disease
    • Koenig W, Rosenson RS. Acute-phase reactants and coronary heart disease. Semin. Vasc. Med. 2, 417-428 (2002).
    • (2002) Semin. Vasc. Med. , vol.2 , pp. 417-428
    • Koenig, W.1    Rosenson, R.S.2
  • 5
    • 11344279659 scopus 로고    scopus 로고
    • Pravastatin or Atorvastatin Evaluation and Infection Therapy - Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy
    • Ridker PM, Cannon CP, Morrow D, et al. Pravastatin or Atorvastatin Evaluation and Infection Therapy - Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. 352, 20-28 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 20-28
    • Ridker, P.M.1    Cannon, C.P.2    Morrow, D.3
  • 6
    • 33748064338 scopus 로고    scopus 로고
    • Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to- Zocor Trial
    • Morrow DA, de Lemos JA, Sabatine MS, et al. Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to- Zocor Trial. Circulation 114, 281-288 (2006).
    • (2006) Circulation , vol.114 , pp. 281-288
    • Morrow, D.A.1    De Lemos, J.A.2    Sabatine, M.S.3
  • 7
    • 0032169240 scopus 로고    scopus 로고
    • Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels
    • Cholesterol and Recurrent Events (CARE) Investigators
    • Ridker PM, Rifai N, Pfeffer MA, et al. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation 98, 839-844 (1998).
    • (1998) Circulation , vol.98 , pp. 839-844
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3
  • 8
    • 77649223536 scopus 로고    scopus 로고
    • Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: A meta-analysis of longitudinal studies
    • He L-P, Tang X-Y, Ling W-H, et al. Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies. Heart 96, 339-346 (2010).
    • (2010) Heart , vol.96 , pp. 339-346
    • He, L.-P.1    Tang, X.-Y.2    Ling, W.-H.3
  • 9
    • 2642520456 scopus 로고    scopus 로고
    • Atherosclerotic Vascular Disease Conference: Writing Group II: Risk factors
    • Smith SC Jr, Milani RV, Arnett DK, et al. Atherosclerotic Vascular Disease Conference: Writing Group II: risk factors. Circulation 109, 2613-2616 (2004).
    • (2004) Circulation , vol.109 , pp. 2613-2616
    • Smith Jr., S.C.1    Milani, R.V.2    Arnett, D.K.3
  • 10
    • 73449108039 scopus 로고    scopus 로고
    • C-reactive protein and coronary disease: Is there a causal link?
    • Danesh J, Pepys MB: C-reactive protein and coronary disease: is there a causal link? Circulation 120, 2036-2039 (2009).
    • (2009) Circulation , vol.120 , pp. 2036-2039
    • Danesh, J.1    Pepys, M.B.2
  • 11
    • 58549103715 scopus 로고    scopus 로고
    • Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease
    • Rosenson RS. Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease. Cardiovasc. Drugs Ther. 23, 93-101 (2009).
    • (2009) Cardiovasc. Drugs Ther. , vol.23 , pp. 93-101
    • Rosenson, R.S.1
  • 12
    • 78650307469 scopus 로고    scopus 로고
    • Phospholipase A2 inhibition and atherosclerotic vascular disease: Prospects for targeting secretory and lipoproteinassociated phospholipase A2 enzymes
    • Rosenson RS. Phospholipase A2 inhibition and atherosclerotic vascular disease: prospects for targeting secretory and lipoproteinassociated phospholipase A2 enzymes. Curr. Opin. Lipidol. 21(6), 473-480 (2010).
    • (2010) Curr. Opin. Lipidol. , vol.21 , Issue.6 , pp. 473-480
    • Rosenson, R.S.1
  • 13
    • 72849108951 scopus 로고    scopus 로고
    • Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes
    • Rosenson RS, Gelb MH: Secretory phospholipase A2: a multifaceted family of proatherogenic enzymes. Curr. Cardiol. Rep. 11, 445-451 (2009).
    • (2009) Curr. Cardiol. Rep. , vol.11 , pp. 445-451
    • Rosenson, R.S.1    Gelb, M.H.2
  • 14
    • 0023924984 scopus 로고
    • Lipolysis of LDL with phospholipase A2 alters the expression of selected ApoB-100 epitopes and the interaction of LDL with cells
    • Kleinman Y, Krul ES, Burnes M, et al. Lipolysis of LDL with phospholipase A2 alters the expression of selected ApoB-100 epitopes and the interaction of LDL with cells. J. Lipid Res. 29, 729-743 (1988).
    • (1988) J. Lipid Res. , vol.29 , pp. 729-743
    • Kleinman, Y.1    Krul, E.S.2    Burnes, M.3
  • 15
    • 1542343997 scopus 로고    scopus 로고
    • Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low density lipoprtoein-containing human apolipoprotein B100
    • Flood C, Gustafsson M, Pitas RE, et al. Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low density lipoprtoein-containing human apolipoprotein B100. Arterioscler. Thromb. Vasc. Biol. 24, 564-570 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 564-570
    • Flood, C.1    Gustafsson, M.2    Pitas, R.E.3
  • 16
    • 19044392084 scopus 로고    scopus 로고
    • Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation
    • Hanasaki K, Yamada K, Yamamoto S, et al. Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation. J. Biol. Chem. 277, 29116-29124 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 29116-29124
    • Hanasaki, K.1    Yamada, K.2    Yamamoto, S.3
  • 17
    • 0033520498 scopus 로고    scopus 로고
    • Phospholipase A2 modification of low density lipoproteins forms small high density particles with increased affinity for proteoglycans and glycosaminoglycans
    • Sartripy P, Camejo G, Svensson L, et al. Phospholipase A2 modification of low density lipoproteins forms small high density particles with increased affinity for proteoglycans and glycosaminoglycans. J. Biol. Chem. 274, 25913-25920 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 25913-25920
    • Sartripy, P.1    Camejo, G.2    Svensson, L.3
  • 18
    • 0035715501 scopus 로고    scopus 로고
    • Lipolysis of LDL by human secretory phospholipase A2 induces particle fusion and enhances the retention of LDL to human aortic proteoglycans
    • Hakala JK, Oorni K, Pentikainen MO, et al. Lipolysis of LDL by human secretory phospholipase A2 induces particle fusion and enhances the retention of LDL to human aortic proteoglycans. Arterioscler. Thromb. Vasc. Biol. 21, 1053-1058 (2001).
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1053-1058
    • Hakala, J.K.1    Oorni, K.2    Pentikainen, M.O.3
  • 19
    • 60249101701 scopus 로고    scopus 로고
    • Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): A Phase II double-blind, randomised, placebo-controlled trial
    • Rosenson RS, Hislop C, McConnell D, et al. Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a Phase II double-blind, randomised, placebo-controlled trial. Lancet 373, 649-658 (2009).
    • (2009) Lancet , vol.373 , pp. 649-658
    • Rosenson, R.S.1    Hislop, C.2    McConnell, D.3
  • 20
    • 77956588584 scopus 로고    scopus 로고
    • Randomized trial of an inhibitor of secretory phospholipase A2 on atherogenic lipoprotein subclasses in statin-treated patients with coronary heart disease
    • Epub ahead of print
    • Rosenson RS, Elliott M, Stasiv Y, et al. Randomized trial of an inhibitor of secretory phospholipase A2 on atherogenic lipoprotein subclasses in statin-treated patients with coronary heart disease. Eur. Heart J. (2010) (Epub ahead of print).
    • (2010) Eur. Heart J.
    • Rosenson, R.S.1    Elliott, M.2    Stasiv, Y.3
  • 21
    • 0037184110 scopus 로고    scopus 로고
    • Group v phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group via phospholipase A2
    • Kim YJ, Kim KP, Han SK, et al. Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group via phospholipase A2. J. Biol. Chem. 277, 36479-36488 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 36479-36488
    • Kim, Y.J.1    Kim, K.P.2    Han, S.K.3
  • 22
    • 0029753778 scopus 로고    scopus 로고
    • Novel group v phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages
    • Balboa MA, Balsinde J, Winstead MV, et al. Novel group V phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages. J. Biol. Chem. 271, 32381-32384 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 32381-32384
    • Balboa, M.A.1    Balsinde, J.2    Winstead, M.V.3
  • 23
    • 3042690158 scopus 로고    scopus 로고
    • Regulation of macrophage foam cell formation by ab3 integrin: Potential role in human atherosclerosis
    • Antonov AS, Kolodgie FD, Munn DH, et al. Regulation of macrophage foam cell formation by ab3 integrin: potential role in human atherosclerosis. Am. J. Pathol. 165, 247-258 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 247-258
    • Antonov, A.S.1    Kolodgie, F.D.2    Munn, D.H.3
  • 24
    • 77956571375 scopus 로고    scopus 로고
    • Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients
    • Rosenson RS, Hislop C, Elliott M, et al. Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients. J. Am. Coll. Cardiol. 56, 1079-1088 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1079-1088
    • Rosenson, R.S.1    Hislop, C.2    Elliott, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.