Effect of thapsigargin on P-glycoprotein-negative and P-glycoprotein- positive L1210 mouse leukaemia cells

General Physiology and Biophysics

Volumn 29, Issue 4, 2010, Pages 396-401

  Sereš, Mário ^a   Ditte, Peter ^b   Breier, Albert ^a   Sulová, Zdena ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Calnexin; GAPDH; L1210 cells; Multidrug resistance; P glycoprotein; Thapsigargin

Indexed keywords

CALNEXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN P; THAPSIGARGIN; VINCRISTINE;

ANIMAL CELL; ARTICLE; GENETIC TRANSFECTION; LEUKEMIA CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN;

ANIMALS; CALNEXIN; CELL DEATH; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA L1210; MICE; P-GLYCOPROTEINS; RNA, MESSENGER; THAPSIGARGIN; TRANSFECTION; VINCRISTINE;

EID: 78650631011     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: 10.4149/gpb_2010_04_396     Document Type: Article

References (23)

1. Baguley B. C. (2010): Multidrug resistance in cancer. Methods MoI. Biol. 596, 1-14; doi:10.1007/978-1-60761-416-6-1
2. Breier A., Barancik M., Sulova Z., Uhrik B. (2005): P-glycoprotein - implications of metabolism of neoplastic cells and cancer therapy. Curr. Cancer Drug Targets 5, 457-468; doi: 10.2174/1568009054863636
3. Broxterman H. J., Gotink K. J., Verheul H. M. (2009): Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist. Updat. 12,114-126; doi:10.1016/j.drup.2009.07.001
4. Chaudhary K. S., Abel P. D., Stamp G. W., Lalani E. (2001): Differential expression of cell death regulators in response to thapsigargin and adriamycin in Bcl-2 transfected DU145 prostatic cancer cells. J. Pathol. 193, 522-529; doi:10.1002/1096-9896(2000)9999:9999〈::AID-PATH821〉3.0.CO;2-Y
5. Gibalova L., Sedlak J., Labudova M., Barancik M., Rehakova A., Breier A., Sulova Z. (2009): Multidrug resistant P-glycoprotein positive L1210/VCR cells are also cross-resistant to cisplatin via a mechanism distinct from P-glycoproteinmediated drug efflux activity. Gen. Physiol. Biophys. 28, 391 -403; doi: 10.4149/pb-2009-04-391
6. 2+ transport ATPase and P-glycoprotein expression can mediate resistance to thapsigargin. J. Biol. Chem. 269, 7976-7981
7. Hall M. D., Handley M. D., Gottesman M. M. (2009): Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol. Sci. 30, 546-556; doi: 10.1016/ j.tips.2009.07.003
8. Liu R., Zhang Y., Chen Y., Qi J., Ren S., Xushi M. Y., Yang C., Zhu H., Xiong D. (2010): A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells. J. Pharm. Sci. 99, 3266-3275
9. Loo T. W., Bartlett M. C., Clarke D. M. (2004): Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein. Biochem. Biophys. Res. Commun. 325, 580-585; doi: 10.1016/j.bbrc.2004.10.070
10. Loo T. W., Clarke D. M. (1994): Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis. J. Biol. Chem. 269, 28683-28689
11. Loo T. W., Clarke D. M. (1995): P-glycoprotein. Associations between domains and between domains and molecular chaperones. J. Biol. Chem. 270, 21839-21844
12. Mestdagh N., Vandewalle B., Hornez L., Henichart J. P. (1994): Comparative study of intracellular calcium and adenosine 3′,5′- cyclic monophosphate levels in human breast carcinoma cells sensitive or resistant to Adriamycin: contribution to reversion of chemoresistance. Biochem. Pharmacol. 48, 709-716; doi: 10.1016/00062952(94)90048-5
13. O'Neill J. P., Velalar C. N., Lee D. I., Zhang B., Nakanishi T., Tang Y., Selaru F., Ross D., Meltzer S. J., Hussain A. (2006): Thapsigargin resistance in human prostate cancer cells. Cancer 107,649-659; doi:10.1002/cncr.22027
14. Pastan I., Gottesman M. M., Ueda K., Lovelace E., Rutherford A. V., Willingham M. C. (1988): A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc. Natl. Acad. Sci. U. S. A. 85, 4486-4490; doi:10.1073/ pnas.85.12.4486
15. Polekova L., Barancik M., Mrazova T., Pirker R., Wallner J., Sulova Z., Breier A. (1992): Adaptation of mouse leukemia cells L1210 to vincristine. Evidence for expression of P-glycoprotein. Neoplasma 39, 73-77
16. 2+ transport ATPase in thapsigarginresistant hamster smooth muscle cells. Nucleic Acids Res. 26,4529-4537; doi:10.1093/nar/26.19.4529
17. Rumjanek V. M., Trindade G. S., Wagner-Souza K., de-Oliveira M. C., Marques-Santos L. E, Maia R. C., Capella M. A. (2001): Multidrug resistance in tumour cells: characterization of the multidrug resistant cell line K562-Lucena 1. An. Acad. Bras. Cienc. 73, 57-69; doi: 10.1590/S000137652001000100007
18. Seres M., Polakova E., Krizanova O., Hudecova S., Klymenko S. V., Breier A., Sulova Z. (2008): Overexpression of P-glycoprotein in L1210/VCR cells is associated with changes in several endoplasmic reticulum proteins that may be partially responsible for the lack of thapsigargin sensitivity. Gen. Physiol. Biophys. 27, 211-221
19. Shoback D., Chen T. H., Pratt S., Lattyak B. (1995): Thapsigargin stimulates intracellular calcium mobilization and inhibits parathyroid hormone release. J. Bone Miner. Res. 10, 743-750; doi:10.1002/jbmr.5650100511
20. Sulova Z., Ditte P., Kurucova T., Polakova E., Rogozanova K., Gibalova L, Seres M., Skvarkova L., Sedlak J., Pastorek J., Breier A. (2010): The Presence of P-glycoprotein in L1210 Cells Directly Induces Down-Regulation of Cell Surface SaccharideTargets of Concanavalin A. Anticancer Res. (in press)
21. 2+. Biochem. Biophys. Res. Commun. 335, 777-784; doi:10.1016/j.bbrc.2005.07.144
22. Sulova Z., Seres M., Barancik M., Gibalova L., Uhrik B., Polekova L., Breier A. (2009): Does exists any relation between P-glycoprotein mediated multidrug resistance and intracellular calcium homeostasis. Gen. Physiol. Biophys. (Focused Issue) 28, F89-95
23. Wagner-Souza K., Echevarria-Lima J., Rodrigues L. A., Reis M., Rumjanek V. M. (2003): Resistance to thapsigargin-induced intracellular calcium mobilization in a multidrug resistant tumour cell line. Mol. Cell. Biochem. 252, 109-116; doi: 10.1023/A: 1025586225941