Human activated CD4+ T lymphocytes increase IL-2 expression by downregulating microRNA-181c

Molecular Immunology

Volumn 48, Issue 4, 2011, Pages 592-599

  Xue, Qian ^a   Guo, Zhang Yan ^a   Li, Wei ^a   Wen, Wei Hong ^a   Meng, Yan Ling ^a   Jia, Lin Tao ^a   Wang, Jian ^a   Yao, Li Bo ^a   Jin, Bo Quan ^a   Wang, Tao ^a   Yang, An Gang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Activation; CD4+ T cell; IL 2; MiR 181c; MiRNA

Indexed keywords

INTERLEUKIN 2; MICRORNA; MICRORNA 181C; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; T LYMPHOCYTE ACTIVATION; TRANSLATION REGULATION;

ADULT; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICRORNAS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER;

EID: 78650619708     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.10.021     Document Type: Article

References (29)

1. Beadling C., Smith K.A. DNA array analysis of interleukin-2-regulated immediate/early genes. Med. Immunol. 2002, 1:2.
2. Chen C.Z., Li L., Lodish H.F., Bartel D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004, 303:83-86.
3. Chen G., Zhu W., Shi D., Lv L., Zhang C., Liu P., Hu W. microRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol. Rep. 2010, 23:997-1003.
4. Chen K., Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat. Rev. Genet. 2007, 8:93-103.
5. Chong M.M., Rasmussen J.P., Rudensky A.Y., Littman D.R. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J. Exp. Med. 2008, 205:2005-2017.
6. Davidson-Moncada J., Papavasiliou F.N., Tam W. MicroRNAs of the immune system: roles in inflammation and cancer. Ann. N.Y. Acad. Sci. 2010, 1183:183-194.
7. De Santis G., Ferracin M., Biondani A., Caniatti L., Rosaria Tola M., Castellazzi M., Zagatti B., Battistini L., Borsellino G., Fainardi E., Gavioli R., Negrini M., Furlan R., Granieri E. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J. Neuroimmunol. 2010, 226:165-171.
8. de Yébenes V.G., Belver L., Pisano D.G., González S., Villasante A., Croce C., He L., Ramiro A.R. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J. Exp. Med. 2008, 205:2199-2206.
9. Du C., Liu C., Kang J., Zhao G., Ye Z., Huang S., Li Z., Wu Z., Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 2009, 10:1252-1259.
10. Esquela-Kerscher A., Slack F.J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
11. Harada Y., Ohgai D., Watanabe R., Okano K., Koiwai O., Tanabe K., Toma H., Altman A., Abe R. A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS). J. Exp. Med. 2003, 197:257-262.
12. He L., Hannon G.J. MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 2004, 5:522-531.
13. Hezova R., Slaby O., Faltejskova P., Mikulkova Z., Buresova I., Raja K.R., Hodek J., Ovesna J., Michalek J. microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell. Immunol. 2010, 260:70-74.
14. Li Q.J., Chau J., Ebert P.J., Sylvester G., Min H., Liu G., Braich R., Manoharan M., Soutschek J., Skare P., Klein L.O., Davis M.M., Chen C.Z. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 2007, 129:147-161.
15. Liston A., Lu L.F., O'Carroll D., Tarakhovsky A., Rudensky A.Y. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J. Exp. Med. 2008, 205:1993-2004.
16. Neilson J.R., Zheng G.X., Burge C.B., Sharp P.A. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 2007, 21:578-589.
17. Nurieva R., Thomas S., Nguyen T., Martin-Orozco N., Wang Y., Kaja M.K., Yu X.Z., Dong C. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J. 2006, 25:2623-2633.
18. Pei Y., Zhu P., Dang Y., Wu J., Yang X., Wan B., Liu J.O., Yi Q., Yu L. Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation. J. Immunol. 2008, 180:222-229.
19. Pekarsky Y., Santanam U., Cimmino A., Palamarchuk A., Efanov A., Maximov V., Volinia S., Alder H., Liu C.G., Rassenti L., Calin G.A., Hagan J.P., Kipps T., Croce C.M. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006, 66:11590-11593.
20. Rodriguez A., Vigorito E., Clare S., Warren M.V., Couttet P., Soond D.R., van Dongen S., Grocock R.J., Das P.P., Miska E.A., Vetrie D., Okkenhaug K., Enright A.J., Dougan G., Turner M., Bradley A. Requirement of bic/microRNA-155 for normal immune function. Science 2007, 316:608-611.
21. Shi L., Cheng Z., Zhang J., Li R., Zhao P., Fu Z., You Y. hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res. 2008, 1236:185-193.
22. Shivdasani R.A. MicroRNAs: regulators of gene expression and cell differentiation. Blood 2006, 108:3646-3653.
23. Sonkoly E., Ståhle M., Pivarcsi A. MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin. Cancer Biol. 2008, 18:131-140.
24. Sonkoly E., Janson P., Majuri M.L., Savinko T., Fyhrquist N., Eidsmo L., Xu N., Meisgen F., Wei T., Bradley M., Stenvang J., Kauppinen S., Alenius H., Lauerma A., Homey B., Winq, vist O., Ståhle M., Pivarcsi A. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J. Allergy Clin. Immunol. 2010, 126. 581-9.e-20.
25. Thai T.H., Calado D.P., Casola S., Ansel K.M., Xiao C., Xue Y., Murphy A., Frendewey D., Valenzuela D., Kutok J.L., Schmidt-Supprian M., Rajewsky N., Yancopoulos G., Rao A., Rajewsky K. Regulation of the germinal center response by microRNA-155. Science 2007, 316:604-608.
26. Thomas R.M., Gao L., Wells A.D. Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J. Immunol. 2005, 174:4639-4646.
27. Wang B., Hsu S.H., Majumder S., Kutay H., Huang W., Jacob S.T., Ghoshal K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010, 29:1787-1797.
28. Wu H., Neilson J.R., Kumar P., Manocha M., Shankar P., Sharp P.A., Manjunath N. miRNA profiling of naïve effector and memory CD8 T Cells. PLoS ONE 2007, 2:e1020.
29. Xiao C., Rajewsky K. MicroRNA control in the immune system: basic principles. Cell 2009, 136:26-36.