Discovery of 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride as a deoxofluorinating agent with high thermal stability as well as unusual resistance to aqueous hydrolysis, and its diverse fluorination capabilities including deoxofluoro-arylsulfinylation with high stereoselectivity

Journal of the American Chemical Society

Volumn 132, Issue 51, 2010, Pages 18199-18205

  Umemoto, Teruo ^a   Singh, Rajendra P ^a   Xu, Yong ^a,b   Saito, Norimichi ^a,c  

^a IM and T Research Inc   (United States)

^b Supergen Inc   (United States)

^c UBE INDUSTRIES LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ALCOHOLS; CARBOXYLIC GROUP; CONFORMATIONAL ISOMERS; CRYSTALLINE SOLIDS; DIVERSE PROPERTIES; DRUG DISCOVERY; FLUORINATED COMPOUND; FLUORINATING AGENTS; FLUORINE ATOMS; HIGH STABILITY; HIGH THERMAL STABILITY; HIGH YIELD; HYDROLYTIC STABILITY; INVERSION OF CONFIGURATION; SELECTIVE FORMATION; STEREO-SELECTIVE; SULFUR ATOMS; THERMALLY STABLE; TRIFLUORIDES;

ACCIDENT PREVENTION; ALCOHOLS; ALDEHYDES; FLUORINATION; HALOGENATION; KETONES; ORGANIC POLYMERS; STEREOSELECTIVITY; SULFUR; THERMODYNAMIC STABILITY;

FLUORINE;

4 TERT BUTYL 2,6 DIMETHYLPHENYLSULFUR TRIFLUORIDE; ALCOHOL; ALDEHYDE; AMINOALCOHOL; CARBOXYLIC ACID; FLUORIDE; KETONE; SULFINIC ACID DERIVATIVE; SULFOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONFORMATION; CRYSTAL STRUCTURE; DECOMPOSITION; FLUORINATION; HYDROLYSIS; ISOMER; REACTION ANALYSIS; SOLID; STEREOCHEMISTRY; SULFINYLATION; SYNTHESIS; THERMOSTABILITY;

ARYLSULFONATES; HALOGENATION; HOT TEMPERATURE; HYDROCARBONS, FLUORINATED; HYDROLYSIS; WATER;

EID: 78650613907     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106343h     Document Type: Article

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