Gene expression signatures of breast tissue before and after cross-sex hormone therapy in female-to-male transsexuals

Fertility and Sterility

Volumn 94, Issue 7, 2010, Pages 2688-2696

  Bentz, Eva Katrin ^a   Pils, Dietmar ^a   Bilban, Martin ^a   Kaufmann, Ulrike ^a   Hefler, Lukas A ^a   Reinthaller, Alexander ^a   Singer, Christian F ^a   Huber, Johannes C ^a   Horvat, Reinhard ^a   Tempfer, Clemens B ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

breast; gender; gene expression; microarray; sex steroids; Transsexualism

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; LYNESTRENOL; PROTEASOME; PROTEIN C FOS; PROTEIN C JUN; TESTOSTERONE UNDECANOATE; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR JUND; UBIQUITIN;

ARTICLE; BLOOD SAMPLING; BREAST; BREAST BIOPSY; CLINICAL ARTICLE; CROSS SEX HORMONE THERAPY; DATA BASE; DOWN REGULATION; FEMALE; FEMALE TO MALE TRANSSEXUAL; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC PROCEDURES; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEGRADATION; UPREGULATION;

ADMINISTRATION, ORAL; BREAST; BREAST NEOPLASMS; CARCINOMA; CHEMOTAXIS, LEUKOCYTE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENES, NEOPLASM; GONADAL STEROID HORMONES; HUMANS; INJECTIONS, INTRAMUSCULAR; LYNESTRENOL; MALE; MICROARRAY ANALYSIS; SEX REASSIGNMENT PROCEDURES; TESTOSTERONE; TRANSSEXUALISM; TUMOR MARKERS, BIOLOGICAL; VALIDATION STUDIES AS TOPIC;

EID: 78650611567     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.04.024     Document Type: Article

References (20)

1. G.R. Brown A review of clinical approaches to gender dysphoria J Clin Psychiatry 51 1990 57 64
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 American Psychiatric Association Washington, DC
3. M. Landen, J. Walinder, and B. Lundstrom Prevalence, incidence and sex ratio of transsexualism Acta Psychiatr 93 1996 221 223
4. A. Bakker, P.J. van Kesteren, L.J. Gooren, and P.D. Bezemer The prevalence of transsexualism in The Netherlands Acta Psychiatr Scand 87 1993 237 238
5. R. Green Family cooccurrence of "gender dysphoria": ten sibling or parent-child pairs Arch Sex Behav 29 2000 499 507
6. E.K. Bentz, L.A. Hefler, U. Kaufmann, J.C. Huber, A. Kolbus, and C.B. Tempfer A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism Fertil Steril 90 2008 56 59
7. S.H. van Goozen, D. Slabbekoorn, L.J. Gooren, G. Sanders, and P.T. Cohen-Kettenis Organizing and activating effects of sex hormones in homosexual individuals Behav Neurosci 116 2002 982 988
8. J. Walinder, and I. Thuwe A study of consanguinity between the parents of transsexuals Br J Psychiatr 131 1977 73 74
9. E. Moore, A. Wisniewski, and A. Dobs Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects J Clin Endocrinol Metab 88 2003 3467 3473
10. J. Ott, U. Kaufmann, E.K. Bentz, J.C. Huber, and C.B. Tempfer Incidence of thrombophilia and venous thrombosis in transsexuals under cross-sex hormone therapy Fertil Steril 93 2010 1267 1272
11. G.K. Smyth Linear models and empirical Bayes methods for assessing differential expression in microarray experiments Stat Appl Genet Mol Biol 3 2004 [Epub February 12, 2004.]
12. S. Hochreiter, D.A. Clevert, and K. Obermayer A new summarization method for Affymetrix probe level data Bioinformatics 22 2006 943 949
13. W. Talloen, D.A. Clevert, S. Hochreiter, D. Amaratunga, L. Bijnens, and S. Kass I/NI-calls for the exclusion of noninformative genes: a highly effective filtering tool for microarray data Bioinformatics 23 2007 2897 2902
14. V.G. Tusher, R. Tibshirani, and G. Chu Significance analysis of microarrays applied to the ionizing radiation response Proc Natl Acad Sci U S A 98 9 2001 5116 5121
15. R Development Core Team R: a language and environment for statistical computing Accessed February 1, 2010 R Foundation for Statistical Computing Vienna Available at: http://www.R-project.org
16. R.C. Gentleman, V.J. Carey, D.M. Bates, B. Bolstad, M. Dettling, and S. Dudoit Bioconductor: open software development for computational biology and bioinformatics Genome Biol 5 2004 R80
17. W. Huang, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat Protoc 4 2009 44 57
18. A. Huber, G. Hudelist, M. Knöfler, L. Saleh, J.C. Huber, and C.F. Singer Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo Fertil Steril 88 2007 1232 1239
19. P. Mukhopadhyay, K.H. Horn, R.M. Greene, and M.M. Pisano Prenatal exposure to environmental tobacco smoke alters gene expression in the developing murine hippocampus Reprod Toxicol 29 2 2010 164 175
20. M.J. Labonte, P.M. Wilson, W. Fazzone, S. Groshen, H.J. Lenz, and R.D. Ladner DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines BMC Med Genomics 2 2009 67