Discovery of 4-Benzylamino-Substituted α-Carbolines as a Novel Class of Receptor Tyrosine Kinase Inhibitors

ChemMedChem

Volumn 6, Issue 1, 2011, Pages 63-72

  Krug, Martin ^a   Wichapong, Kanin ^a   Erlenkamp, German ^a   Sippl, Wolfgang ^a   Schächtele, Christoph ^b   Totzke, Frank ^b   Hilgeroth, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b PROQINASE GMBH   (Germany)

Author keywords

Biological activity; Drug discovery; Growth factors; Inhibitors; Medicinal chemistry; Receptors

Indexed keywords

4 BENZYLAMINO 1 AZA 9 OXAFLUORENE; 6 BROMO 4 CHLORO 9H PYRIDO[2,3 B]INDOLE; BLEOMYCIN; CARBOLINE DERIVATIVE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOPOSIDE; IRINOTECAN; MELPHALAN; N (1 PHENYLETHYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N (3 CHLOROBENZYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N (4 CHLOROBENZYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N (4 METHOXYBENZYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N (NAPHTHALENE 1 YLMETHYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N (PYRIDINE 3 YLMETHYL) 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N BENZYL 6 BROMO 9H PYRIDO[2,3 B]INDOLE; N BENZYL 9H PYRIDO[2,3 B]INDOLE 4 AMINE; N PHENYLETHYL 9H PYRIDO[2,3 B]INDOLE 4 AMINE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG BINDING; DRUG RESISTANCE; DRUG SYNTHESIS; MOLECULAR DOCKING; PRIORITY JOURNAL;

CARBOLINES; CELL PROLIFERATION; CELLS, CULTURED; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 78650570591     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000384     Document Type: Article

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