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Volumn 29, Issue 4, 2011, Pages 795-803

Immunogenicity, safety, biodistribution and persistence of ADVAX, a prophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation

Author keywords

DNA vaccine; Electroporation; Integration

Indexed keywords

ADVAX; DNA VACCINE; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; UNCLASSIFIED DRUG;

EID: 78650568204     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.11.011     Document Type: Article
Times cited : (50)

References (59)
  • 1
    • 0020596551 scopus 로고
    • Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • Barré-Sinoussi F., Chermann J.C., Rey F., Nugeyre M.T., Chamaret S., Gruest J., et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 1983, 220(4599):868-871.
    • (1983) Science , vol.220 , Issue.4599 , pp. 868-871
    • Barré-Sinoussi, F.1    Chermann, J.C.2    Rey, F.3    Nugeyre, M.T.4    Chamaret, S.5    Gruest, J.6
  • 2
    • 0021261510 scopus 로고
    • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
    • Gallo R.C., Salahuddin S.Z., Popovic M., Shearer G.M., Kaplan M., Haynes B.F., et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 1984, 224(4648):500-503.
    • (1984) Science , vol.224 , Issue.4648 , pp. 500-503
    • Gallo, R.C.1    Salahuddin, S.Z.2    Popovic, M.3    Shearer, G.M.4    Kaplan, M.5    Haynes, B.F.6
  • 5
    • 0035815437 scopus 로고    scopus 로고
    • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    • Amara R.R., Villinger F., Altman J.D., Lydy S.L., O'Neil S.P., Staprans S.I., et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 2001, 292:69-74.
    • (2001) Science , vol.292 , pp. 69-74
    • Amara, R.R.1    Villinger, F.2    Altman, J.D.3    Lydy, S.L.4    O'Neil, S.P.5    Staprans, S.I.6
  • 6
    • 0038714287 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    • McConkey S.J., Reece W.H., Moorthy V.S., Webster D., Dunachie S., Butcher G., et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 2003, 9:729-735.
    • (2003) Nat Med , vol.9 , pp. 729-735
    • McConkey, S.J.1    Reece, W.H.2    Moorthy, V.S.3    Webster, D.4    Dunachie, S.5    Butcher, G.6
  • 7
    • 33646454992 scopus 로고    scopus 로고
    • Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 gag coupled to CD8+ T-cell epitopes
    • Goonetilleke N., Moore S., Dally L., Winstone N., Cebere I., Mahmoud A., et al. Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 gag coupled to CD8+ T-cell epitopes. J Virol 2006, 80:4717-4728.
    • (2006) J Virol , vol.80 , pp. 4717-4728
    • Goonetilleke, N.1    Moore, S.2    Dally, L.3    Winstone, N.4    Cebere, I.5    Mahmoud, A.6
  • 8
    • 38749132973 scopus 로고    scopus 로고
    • An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
    • Harari A., Bart P.A., Stöhr W., Tapia G., Garcia M., Medjitna-Rais E., et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med 2008, 205:63-77.
    • (2008) J Exp Med , vol.205 , pp. 63-77
    • Harari, A.1    Bart, P.A.2    Stöhr, W.3    Tapia, G.4    Garcia, M.5    Medjitna-Rais, E.6
  • 9
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: immunology, application, and optimization
    • Gurunathan S., Klinman D.M., Seder R.A. DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 2000, 18:927-974.
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 11
    • 70349471292 scopus 로고    scopus 로고
    • DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge
    • [Epub 2009 August 28], S 15
    • Rosati M., Bergamaschi C., Valentin A., Kulkarni V., Jalah R., Alicea C., et al. DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge. Proc Natl Acad Sci U S A 2009 Sep 15, 106(37):15831-15836. [Epub 2009 August 28].
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.37 , pp. 15831-15836
    • Rosati, M.1    Bergamaschi, C.2    Valentin, A.3    Kulkarni, V.4    Jalah, R.5    Alicea, C.6
  • 12
    • 0036120632 scopus 로고    scopus 로고
    • Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine
    • April
    • Fuller D.H., Rajakumar P.A., Wilson L.A., Trichel A.M., Fuller J.T., Shipley T., et al. Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine. J Virol 2002, 76(April (7)):3309-3317.
    • (2002) J Virol , vol.76 , Issue.7 , pp. 3309-3317
    • Fuller, D.H.1    Rajakumar, P.A.2    Wilson, L.A.3    Trichel, A.M.4    Fuller, J.T.5    Shipley, T.6
  • 14
    • 33745961311 scopus 로고    scopus 로고
    • Excellent safety and tolerability of the human immunodeficiency virus type 1 pGA2/JS2 plasmid DNA priming vector vaccine in HIV type 1 uninfected adults
    • Mulligan M.J., Russell N.D., Celum C., Kahn J., Noonan E., Montefiori D.C., et al. Excellent safety and tolerability of the human immunodeficiency virus type 1 pGA2/JS2 plasmid DNA priming vector vaccine in HIV type 1 uninfected adults. AIDS Res Hum Retroviruses 2006, 22:678-683.
    • (2006) AIDS Res Hum Retroviruses , vol.22 , pp. 678-683
    • Mulligan, M.J.1    Russell, N.D.2    Celum, C.3    Kahn, J.4    Noonan, E.5    Montefiori, D.C.6
  • 15
    • 34247201441 scopus 로고    scopus 로고
    • Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
    • Catanzaro A.T., Roederer M., Koup R.A., Bailer R.T., Enama M.E., Nason M.C., et al. Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 2007, 25:4085-4092.
    • (2007) Vaccine , vol.25 , pp. 4085-4092
    • Catanzaro, A.T.1    Roederer, M.2    Koup, R.A.3    Bailer, R.T.4    Enama, M.E.5    Nason, M.C.6
  • 16
    • 33845412550 scopus 로고    scopus 로고
    • Phase I safety and immunogenicity evaluation of a multiclade HIV-1 candidate DNA vaccine
    • Graham B.S., Koup R.A., Roederer M., Bailer R.T., Enama M.E., Moodie Z., et al. Phase I safety and immunogenicity evaluation of a multiclade HIV-1 candidate DNA vaccine. J Infect Dis 2006, 194:1650-1660.
    • (2006) J Infect Dis , vol.194 , pp. 1650-1660
    • Graham, B.S.1    Koup, R.A.2    Roederer, M.3    Bailer, R.T.4    Enama, M.E.5    Moodie, Z.6
  • 17
    • 37249087254 scopus 로고    scopus 로고
    • Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults
    • Gorse G.J., Baden L.R., Wecker M., Newman M.J., Ferrari G., Weinhold K.J., et al. Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults. Vaccine 2008, 26(2):215-223.
    • (2008) Vaccine , vol.26 , Issue.2 , pp. 215-223
    • Gorse, G.J.1    Baden, L.R.2    Wecker, M.3    Newman, M.J.4    Ferrari, G.5    Weinhold, K.J.6
  • 18
    • 43049181912 scopus 로고    scopus 로고
    • Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
    • Jaoko W., Nakwagala F.N., Anzala O., Manyonyi G.O., Birungi J., Nanvubya A., et al. Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa. Vaccine 2008, 26(22):2788-2795.
    • (2008) Vaccine , vol.26 , Issue.22 , pp. 2788-2795
    • Jaoko, W.1    Nakwagala, F.N.2    Anzala, O.3    Manyonyi, G.O.4    Birungi, J.5    Nanvubya, A.6
  • 20
  • 21
    • 62949237235 scopus 로고    scopus 로고
    • DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial
    • Jones S., Evans K., McElwaine-Johnn H., Sharpe M., Oxford J., Lambkin-Williams R., et al. DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial. Vaccine 2009, 27(18):2506-2512.
    • (2009) Vaccine , vol.27 , Issue.18 , pp. 2506-2512
    • Jones, S.1    Evans, K.2    McElwaine-Johnn, H.3    Sharpe, M.4    Oxford, J.5    Lambkin-Williams, R.6
  • 22
    • 36049015389 scopus 로고    scopus 로고
    • Electroporation-based DNA immunisation: translation to the clinic
    • Luxembourg A., Evans C.F., Hannaman D. Electroporation-based DNA immunisation: translation to the clinic. Expert Opin Biol Ther 2007, 7(11):1647-1664.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.11 , pp. 1647-1664
    • Luxembourg, A.1    Evans, C.F.2    Hannaman, D.3
  • 23
    • 2942564030 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency in rhesus macaques by electroporation
    • Otten G., Schaefer M., Doe B., Liu H., Srivastava I., zur Megede J., et al. Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 2004, 22(19):2489-2493.
    • (2004) Vaccine , vol.22 , Issue.19 , pp. 2489-2493
    • Otten, G.1    Schaefer, M.2    Doe, B.3    Liu, H.4    Srivastava, I.5    zur Megede, J.6
  • 24
    • 33646849278 scopus 로고    scopus 로고
    • Enhancement of immune responses to an HBV DNA vaccine by electroporation
    • Luxembourg A., Hannaman D., Ellefsen B., Nakamura G., Bernard R. Enhancement of immune responses to an HBV DNA vaccine by electroporation. Vaccine 2006, 24(21):4490-4493.
    • (2006) Vaccine , vol.24 , Issue.21 , pp. 4490-4493
    • Luxembourg, A.1    Hannaman, D.2    Ellefsen, B.3    Nakamura, G.4    Bernard, R.5
  • 25
    • 73949083734 scopus 로고    scopus 로고
    • Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques
    • Livingston B.D., Little S.F., Luxembourg A., Ellefsen B., Hannaman D. Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques. Vaccine 2010, 28(4):1056-1061.
    • (2010) Vaccine , vol.28 , Issue.4 , pp. 1056-1061
    • Livingston, B.D.1    Little, S.F.2    Luxembourg, A.3    Ellefsen, B.4    Hannaman, D.5
  • 26
    • 37249047376 scopus 로고    scopus 로고
    • Markedly enhanced immunogenicity of a Pfs25 DNA-based malaria transmission-blocking vaccine by in vivo electroporation
    • LeBlanc R., Vasquez Y., Hannaman D., Kumar N. Markedly enhanced immunogenicity of a Pfs25 DNA-based malaria transmission-blocking vaccine by in vivo electroporation. Vaccine 2008, 26(2):185-192.
    • (2008) Vaccine , vol.26 , Issue.2 , pp. 185-192
    • LeBlanc, R.1    Vasquez, Y.2    Hannaman, D.3    Kumar, N.4
  • 27
    • 51349125266 scopus 로고    scopus 로고
    • DNA vaccination and gene therapy: optimization and delivery for cancer therapy
    • Bodles-Brakhop A.M., Draghia-Akli R. DNA vaccination and gene therapy: optimization and delivery for cancer therapy. Expert Rev Vaccines 2008, 7(7):1085-1101.
    • (2008) Expert Rev Vaccines , vol.7 , Issue.7 , pp. 1085-1101
    • Bodles-Brakhop, A.M.1    Draghia-Akli, R.2
  • 28
    • 68349152636 scopus 로고    scopus 로고
    • Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    • Best S.R., Peng S., Juang C.M., Hung C.F., Hannaman D., Saunders J.R., et al. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine 2009, 27(40):5450-5459.
    • (2009) Vaccine , vol.27 , Issue.40 , pp. 5450-5459
    • Best, S.R.1    Peng, S.2    Juang, C.M.3    Hung, C.F.4    Hannaman, D.5    Saunders, J.R.6
  • 29
    • 52449104809 scopus 로고    scopus 로고
    • DNA vaccines: ready for prime time?
    • Kutzler M.A., Weiner D.B. DNA vaccines: ready for prime time?. Nat Rev Genet 2008, 9(10):776-788.
    • (2008) Nat Rev Genet , vol.9 , Issue.10 , pp. 776-788
    • Kutzler, M.A.1    Weiner, D.B.2
  • 31
    • 40549120282 scopus 로고    scopus 로고
    • Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant
    • Huang Y., Chen Z., Zhang W., Gurner D., Song Y., Gardiner D.F., et al. Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. J Acquir Immune Defic Syndr 2008, 47(4):403-411.
    • (2008) J Acquir Immune Defic Syndr , vol.47 , Issue.4 , pp. 403-411
    • Huang, Y.1    Chen, Z.2    Zhang, W.3    Gurner, D.4    Song, Y.5    Gardiner, D.F.6
  • 32
    • 77749321171 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine
    • e8617, 1-7
    • Vasan S., Schlesinger S.J., Huang Y., Hurley A., Lombardo A., Chen Z., et al. Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One 2010, 5(1). e8617, 1-7.
    • (2010) PLoS One , vol.5 , Issue.1
    • Vasan, S.1    Schlesinger, S.J.2    Huang, Y.3    Hurley, A.4    Lombardo, A.5    Chen, Z.6
  • 33
    • 0037350372 scopus 로고    scopus 로고
    • Society of toxicologic pathology. Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the Society of Toxicologic Pathology (STP)
    • Bregman C.L., Adler R.R., Morton D.G., Regan K.S., Yano B.L. Society of toxicologic pathology. Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the Society of Toxicologic Pathology (STP). Toxicol Pathol 2003, 31(2):252-253.
    • (2003) Toxicol Pathol , vol.31 , Issue.2 , pp. 252-253
    • Bregman, C.L.1    Adler, R.R.2    Morton, D.G.3    Regan, K.S.4    Yano, B.L.5
  • 34
    • 0034467028 scopus 로고    scopus 로고
    • Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice
    • Ledwith B.J., Manam S., Troilo P.J., Barnum A.B., Pauley C.J., Griffiths T.G., et al. Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice. Intervirology 2000, 43(4-6):258-272.
    • (2000) Intervirology , vol.43 , Issue.4-6 , pp. 258-272
    • Ledwith, B.J.1    Manam, S.2    Troilo, P.J.3    Barnum, A.B.4    Pauley, C.J.5    Griffiths, T.G.6
  • 36
    • 37349084570 scopus 로고    scopus 로고
    • Persistent antibody and T cell responses induced by HIV-1 DNA vaccine delivered by electroporation
    • Cristillo A.D., Weiss D., Hudacik L., Restrepo S., Galmin L., Suschak J., et al. Persistent antibody and T cell responses induced by HIV-1 DNA vaccine delivered by electroporation. Biochem Biophys Res Commun 2008, 366(1):29-35.
    • (2008) Biochem Biophys Res Commun , vol.366 , Issue.1 , pp. 29-35
    • Cristillo, A.D.1    Weiss, D.2    Hudacik, L.3    Restrepo, S.4    Galmin, L.5    Suschak, J.6
  • 37
    • 44749083247 scopus 로고    scopus 로고
    • Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques
    • Hirao L.A., Wu L., Khan A.S., Hokey D.A., Yan J., Dai A., et al. Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques. Vaccine 2008, 26(25):3112-3120.
    • (2008) Vaccine , vol.26 , Issue.25 , pp. 3112-3120
    • Hirao, L.A.1    Wu, L.2    Khan, A.S.3    Hokey, D.A.4    Yan, J.5    Dai, A.6
  • 38
    • 43949114521 scopus 로고    scopus 로고
    • Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
    • Liu J., Kjeken R., Mathiesen I., Barouch D.H. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J Virol 2008, 82(11):5643-5649.
    • (2008) J Virol , vol.82 , Issue.11 , pp. 5643-5649
    • Liu, J.1    Kjeken, R.2    Mathiesen, I.3    Barouch, D.H.4
  • 39
    • 0034730585 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency by electroporation in vivo
    • Selby M., Goldbeck C., Pertile T., Walsh R., Ulmer J. Enhancement of DNA vaccine potency by electroporation in vivo. J Biotechnol 2000, 83:147-152.
    • (2000) J Biotechnol , vol.83 , pp. 147-152
    • Selby, M.1    Goldbeck, C.2    Pertile, T.3    Walsh, R.4    Ulmer, J.5
  • 40
    • 18144446323 scopus 로고    scopus 로고
    • Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
    • Widera G., Austin M., Rabussay D., Goldbeck C., Barnett S.W., Chen M., et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 2000, 164:4635-4640.
    • (2000) J Immunol , vol.164 , pp. 4635-4640
    • Widera, G.1    Austin, M.2    Rabussay, D.3    Goldbeck, C.4    Barnett, S.W.5    Chen, M.6
  • 41
    • 50849125106 scopus 로고    scopus 로고
    • Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates
    • Simon A.J., Casimiro D.R., Finnefrock A.C., Davies M.E., Tang A., Chen M., et al. Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates. Vaccine 2008, 26:5202-5209.
    • (2008) Vaccine , vol.26 , pp. 5202-5209
    • Simon, A.J.1    Casimiro, D.R.2    Finnefrock, A.C.3    Davies, M.E.4    Tang, A.5    Chen, M.6
  • 42
    • 33646852606 scopus 로고    scopus 로고
    • Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation
    • Otten G.R., Schaefer M., Doe B., Liu H., Megede J.Z., Donnelly J., et al. Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation. Vaccine 2006, 24:4503-4509.
    • (2006) Vaccine , vol.24 , pp. 4503-4509
    • Otten, G.R.1    Schaefer, M.2    Doe, B.3    Liu, H.4    Megede, J.Z.5    Donnelly, J.6
  • 43
    • 34248382494 scopus 로고    scopus 로고
    • Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
    • Luckay A., Sidhu M.K., Kjeken R., Megati S., Chong S.Y., Roopchand V., et al. Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J Virol 2007, 81(10):5257-5269.
    • (2007) J Virol , vol.81 , Issue.10 , pp. 5257-5269
    • Luckay, A.1    Sidhu, M.K.2    Kjeken, R.3    Megati, S.4    Chong, S.Y.5    Roopchand, V.6
  • 44
    • 44749088148 scopus 로고    scopus 로고
    • EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
    • McCormack S., Stöhr W., Barber T., Bart P.A., Harari A., Moog C., et al. EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone. Vaccine 2008, 26(25):3162-3174.
    • (2008) Vaccine , vol.26 , Issue.25 , pp. 3162-3174
    • McCormack, S.1    Stöhr, W.2    Barber, T.3    Bart, P.A.4    Harari, A.5    Moog, C.6
  • 45
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
    • Betts M.R., Nason M.C., West S.M., De Rosa S.C., Migueles S.A., Abraham J., et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells. Blood 2006, 107:4781-4789.
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3    De Rosa, S.C.4    Migueles, S.A.5    Abraham, J.6
  • 46
  • 47
    • 49649094496 scopus 로고    scopus 로고
    • Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens
    • Laddy D.J., Yan J., Kutzler M., Kobasa D., Kobinger G.P., Khan A.S., et al. Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PLoS One 2008, 3(6):e2517.
    • (2008) PLoS One , vol.3 , Issue.6
    • Laddy, D.J.1    Yan, J.2    Kutzler, M.3    Kobasa, D.4    Kobinger, G.P.5    Khan, A.S.6
  • 48
    • 52149105611 scopus 로고    scopus 로고
    • Electroporation-based DNA transfer enhances gene expression and immune responses to DNA vaccines in cattle
    • October
    • van Drunen Littel-van den Hurk S., Luxembourg A., Ellefsen B., Wilson D., Ubach A., Hannaman D., et al. Electroporation-based DNA transfer enhances gene expression and immune responses to DNA vaccines in cattle. Vaccine 2008, 26(October (43)):5503-5509.
    • (2008) Vaccine , vol.26 , Issue.43 , pp. 5503-5509
    • van Drunen Littel-van den Hurk, S.1    Luxembourg, A.2    Ellefsen, B.3    Wilson, D.4    Ubach, A.5    Hannaman, D.6
  • 49
    • 1942455782 scopus 로고    scopus 로고
    • Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines
    • Babiuk S., Baca-Estrada M.E., Foldvari M., Middleton D.M., Rabussay D., Widera G., et al. Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J Biotechnol 2004, 110(1):1-10.
    • (2004) J Biotechnol , vol.110 , Issue.1 , pp. 1-10
    • Babiuk, S.1    Baca-Estrada, M.E.2    Foldvari, M.3    Middleton, D.M.4    Rabussay, D.5    Widera, G.6
  • 50
    • 0031753867 scopus 로고    scopus 로고
    • Gene transfer into muscle by electroporation in vivo
    • Aihara H., Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998, 16(9):867-870.
    • (1998) Nat Biotechnol , vol.16 , Issue.9 , pp. 867-870
    • Aihara, H.1    Miyazaki, J.2
  • 51
    • 0034283956 scopus 로고    scopus 로고
    • Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice
    • Dupuis M., Denis-Mize K., Woo C., Goldbeck C., Selby M.J., Chen M., et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol 2000, 165(5):2850-2858.
    • (2000) J Immunol , vol.165 , Issue.5 , pp. 2850-2858
    • Dupuis, M.1    Denis-Mize, K.2    Woo, C.3    Goldbeck, C.4    Selby, M.J.5    Chen, M.6
  • 52
    • 11144356610 scopus 로고    scopus 로고
    • Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation
    • Wang Z., Troilo P.J., Wang X., Griffiths T.G., Pacchione S.J., Barnum A.B., et al. Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Ther 2004, 11:711-721.
    • (2004) Gene Ther , vol.11 , pp. 711-721
    • Wang, Z.1    Troilo, P.J.2    Wang, X.3    Griffiths, T.G.4    Pacchione, S.J.5    Barnum, A.B.6
  • 53
    • 0030965404 scopus 로고    scopus 로고
    • Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA
    • Davis H.L., Millan C.L., Watkins S.C. Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA. Gene Ther 1997, 4(3):181-188.
    • (1997) Gene Ther , vol.4 , Issue.3 , pp. 181-188
    • Davis, H.L.1    Millan, C.L.2    Watkins, S.C.3
  • 54
    • 0031589164 scopus 로고    scopus 로고
    • Immune responses, not promoter inactivation, are responsible for decreased long-term expression following plasmid gene transfer into skeletal muscle
    • Wells K.E., Maule J., Kingston R., Foster K., McMahon J., Damien E., et al. Immune responses, not promoter inactivation, are responsible for decreased long-term expression following plasmid gene transfer into skeletal muscle. FEBS Lett 1997, 407(2):164-168.
    • (1997) FEBS Lett , vol.407 , Issue.2 , pp. 164-168
    • Wells, K.E.1    Maule, J.2    Kingston, R.3    Foster, K.4    McMahon, J.5    Damien, E.6
  • 55
    • 33744790917 scopus 로고    scopus 로고
    • Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, severe acute respiratory syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts
    • Sheets R.L., Stein J., Manetz T.S., Duffy C., Nason M., Andrews C., et al. Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, severe acute respiratory syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts. Toxicol Sci 2006, 91(2):610-619.
    • (2006) Toxicol Sci , vol.91 , Issue.2 , pp. 610-619
    • Sheets, R.L.1    Stein, J.2    Manetz, T.S.3    Duffy, C.4    Nason, M.5    Andrews, C.6
  • 56
    • 0033586277 scopus 로고    scopus 로고
    • Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection
    • March
    • Martin T., Parker S.E., Hedstrom R., Le T., Hoffman S.L., Norman J., et al. Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection. Hum Gene Ther 1999, 10(March (5)):759-768.
    • (1999) Hum Gene Ther , vol.10 , Issue.5 , pp. 759-768
    • Martin, T.1    Parker, S.E.2    Hedstrom, R.3    Le, T.4    Hoffman, S.L.5    Norman, J.6
  • 57
    • 26644468124 scopus 로고    scopus 로고
    • II. Cationic lipid-formulated plasmid DNA-based Bacillus anthracis vaccine: evaluation of plasmid DNA persistence and integration potential
    • Vilalta A., Mahajan R.K., Hartikka J., Leamy V., Martin T., Rusalov D., et al. II. Cationic lipid-formulated plasmid DNA-based Bacillus anthracis vaccine: evaluation of plasmid DNA persistence and integration potential. Hum Gene Ther 2005, 16(10):1151-1156.
    • (2005) Hum Gene Ther , vol.16 , Issue.10 , pp. 1151-1156
    • Vilalta, A.1    Mahajan, R.K.2    Hartikka, J.3    Leamy, V.4    Martin, T.5    Rusalov, D.6
  • 58
    • 26644466086 scopus 로고    scopus 로고
    • I. Poloxamer-formulated plasmid DNA-based human cytomegalovirus vaccine: evaluation of plasmid DNA biodistribution/persistence and integration
    • Vilalta A., Mahajan R.K., Hartikka J., Rusalov D., Martin T., Bozoukova V., et al. I. Poloxamer-formulated plasmid DNA-based human cytomegalovirus vaccine: evaluation of plasmid DNA biodistribution/persistence and integration. Hum Gene Ther 2005, 16(10):1143-1150.
    • (2005) Hum Gene Ther , vol.16 , Issue.10 , pp. 1143-1150
    • Vilalta, A.1    Mahajan, R.K.2    Hartikka, J.3    Rusalov, D.4    Martin, T.5    Bozoukova, V.6
  • 59
    • 70449652600 scopus 로고    scopus 로고
    • OA05-01. In vivo electroporation enhances the immunogenicity of ADVAX, a DNA-based HIV-1 vaccine candidate, in healthy volunteers
    • Vasan S., Hurley A., Schlesinger S.J., Hannaman D., Gardiner D.F., Dugin D.P., et al. OA05-01. In vivo electroporation enhances the immunogenicity of ADVAX, a DNA-based HIV-1 vaccine candidate, in healthy volunteers. Retrovirology 2009, 6(Suppl. 3):O31.
    • (2009) Retrovirology , vol.6 , Issue.SUPPL. 3
    • Vasan, S.1    Hurley, A.2    Schlesinger, S.J.3    Hannaman, D.4    Gardiner, D.F.5    Dugin, D.P.6


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