Clinical presentation and autoimmune characteristics of very young children at the onset of type 1 diabetes mellitus

Journal of Pediatric Endocrinology and Metabolism

Volumn 23, Issue 11, 2010, Pages 1151-1157

  Carla, Bizzarri ^a   Danila, Benevento ^a   Paolo, Ciampalini ^a   Patrizia, Patera Ippolita ^a   Riccardo, Schiaffini ^a   Antonella, Migliaccio ^a   Lucilla, Ravà ^b   Marco, Cappa ^a  

^a University Campus Bio Medico   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Beta cell; C peptide; Children; Ketoacidosis; Type 1 diabetes

Indexed keywords

BICARBONATE; C PEPTIDE; GLUTAMATE DECARBOXYLASE ANTIBODY; HEMOGLOBIN A1C; INSULIN ANTIBODY; PROTEIN DERIVATIVE; PROTEIN IA2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CHILD; CLINICAL FEATURE; DISEASE SEVERITY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PANCREAS ISLET BETA CELL; PH;

ADOLESCENT; AUTOANTIBODIES; C-PEPTIDE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFANT; INFANT, NEWBORN; INSULIN ANTIBODIES; INSULIN-SECRETING CELLS; LINEAR MODELS; MALE;

EID: 78650560475     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/jpem.2010.180     Document Type: Article

References (21)

1. Knip M, Veijola A, Virtanen SM, Hyoty H, Vaarala O, Akerblom HK. Environmental triggers and determinants of ß-cell autoimmunity and type 1 diabetes. Diabetes 2005; 54 (suppl 2): S125-S136.
2. Bottazzo GF, Florin-Christensen A, Doniach D. Isletcell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974; 2: 12791283.
3. th century. Diabetes 2002; 51: 3353-3361.
4. Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008; 371: 17771782.
5. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, the EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009;373:2027-2033.
6. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M. A comparison of childhood and adult type 1 diabetes mellitus. N Engl J Med 1989; 320: 881-886.
7. Nmiri R, Phillip M, Shalitin S. Children diagnosed with diabetes during infancy have unique clinical characteristics. Horm Res 2007; 67: 263-267.
8. Steffes MW, Sibley S, Jackson M, Thomas W. Betacell function and the development of diabetes-related complications in the Diabetes Control and Complications Trial. Diabetes Care 2003; 26: 832836.
9. Komulainen J, Kulmala P, Savola K, Lounamaa R, Akerblom HK. The childhood diabetes in Finland Study Group. Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Diabetes Care 1999; 22: 1950-1955.
10. Sachdeva MM, Stoffers DA. Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. MoI Endocrinol. 2009 Jun;23(6):747-58. Epub 2009 Feb 5.
11. Mortensen HB, Swift PG, HoIl RW et al. Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycémie control 12 months after diagnosis. Pediatr Diabetes. 2008 Aug 25. [Epub ahead of print]
12. Pozzilli P, Visalli N, Buzzetti R et al. Metabolic and immune parameters at clinical onset of insulindependent diabetes: a population-based study. IMDIAB Study Group. Immunotherapy Diabetes. Metabolism 1998;47:1205-1210.
13. Pétrone A, Galgani A, Spoletini M et al. Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype. Diabetes Metab Res Rev 2005; 21: 271-275.
14. Picardi A, Visalli N, Lauria A et al. Metabolic factors affecting residual beta cell function assessed by Cpeptide secretion in patients with newly diagnosed type 1 diabetes. Horm Metab Res 2006; 38: 668-672.
15. Salardi S, Zucchini S, Cicognani A et al. The severity of clinical presentation of type 1 diabetes in children does not significantly influence the pattern of residual beta-cell function and long-term metabolic control. Pediatr Diabetes 2003; 4:4-9.
16. Hathout EH, Hartwick N, Fagoada OR et al. Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age. Pediatrics 2003; 111:860-863.
17. Siljander HT, Simell S, Hekkala A et al. Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes. 2009 Dec;58(12):2835-42. Epub 2009 Sep 15.
18. Kimpimäki T, Kupila A, Hämäläinen AM et al. The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001; 86: 4782-4788.
19. Knip M, Kukko M, Kulmala P et al. Humoral betacell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet 2002; 115: 48-54.
20. Sabbah E, Savola K, Kulmala P et al. Diabetesassociated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group. J Clin Endocrinol Metab. 1999;84:1534-1539.
21. Bingley PJ. Clinical Applications of diabetes antibody testing. J Clin Endocrin Metab. First published ahead of print October 29, 2009 as doi:10.1210/jc.2009-1365.