Has the time come for us to complement our malaria parasites?

Trends in Parasitology

Volumn 27, Issue 1, 2011, Pages 1-2

  Goldberg, Daniel E ^a   Janse, Chris J ^b   Cowman, Alan F ^c,d   Waters, Andrew P ^e  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLASTICIDIN S;

DNA MODIFICATION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; LETTER; MALARIA; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PROTEIN STABILITY; TOXOPLASMA; TRANSPOSON;

ANIMALS; GENOME, PROTOZOAN; PLASMODIUM; RECOMBINATION, GENETIC; SELECTION, GENETIC; SPECIES SPECIFICITY;

EID: 78650545419     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2010.06.017     Document Type: Letter

References (15)

1. Carvalho T.G., Ménard R. Manipulating the Plasmodium genome. Curr. Issues Mol. Biol. 2005, 7:39-55.
2. de Koning-Ward T.F., Gilson P.R. Keeping it simple: an easy method for manipulating the expression levels of malaria proteins. Trends Parasitol. 2009, 25:4-7.
3. Carvalho T.G., et al. Conditional mutagenesis using site-specific recombination in Plasmodium berghei. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:14931-14936.
4. Sakamoto H., et al. Conditional mutagenesis using site-specific recombination in Plasmodium berghei. Nucleic Acids Res. 2005, 33:e174.
5. Nkrumah L.J., et al. Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase. Nat. Methods 2006, 3:615-621.
6. Balu B., et al. piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome. BMC Microbiol. 2009, 9:83.
7. Maier A.G., et al. Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell 2008, 134:48-61.
8. Sultan A.A., et al. Complementation of Plasmodium berghei TRAP knockout parasites using human dihydrofolate reductase gene as a selectable marker. Mol. Biochem. Parasitol. 2001, 113:151-156.
9. Dharia N.V., et al. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 2009, 10:R21.
10. Fidock D.A., Wellems T.E. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:10931-10936.
11. Mamoun C.B., et al. A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:8716-8720.
12. Kocken C.H., et al. Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization. J. Biol. Chem. 1998, 273:15119-15224.
13. Braks J.A., et al. Development and application of a positive-negative selectable marker system for use in reverse genetics in Plasmodium. Nucleic Acid Res. 2006, 34:e39.
14. Janse C.J., et al. A genotype and phenotype database of genetically modified rodent malaria parasites - The RMgm database. Trends Parasitol. 2011, 27:31-39.
15. Raine J.D., et al. Female inheritance of malarial lap genes is essential for mosquito transmission. PLoS Pathog. 2007, 3:e30.