A new and efficient synthetic route for the anxiolytic agent CL285032

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 259-261

  Ghidu, Victor P ^a   Ilies, Marc A ^a   Cullen, Tom ^b   Pollet, Robert ^b   Abou Gharbia, Magid ^a  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^b ZOETIS   (United States)

Author keywords

Anxiolytic agent; Noise phobia; Triazolopyridazine synthesis

Indexed keywords

ANXIOLYTIC AGENT; CL 285032; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG ACTIVITY; DRUG FORMULATION; DRUG MANUFACTURE; DRUG MARKETING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHONOPHOBIA;

ANIMALS; ANTI-ANXIETY AGENTS; DOGS; PHOBIC DISORDERS; PYRIDAZINES;

EID: 78650523940     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.017     Document Type: Article

References (7)

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7. 3, δ, ppm): 8.10 (d, J = 9.2 Hz, 1H), 8.02 (t, J = 0.8 Hz, 1H), 7.99 (d, J = 7.6 Hz, 1H), 7.62 (t, J = 7.8 Hz, 1H), 7.54 (d, J = 9.2 Hz, 1H), 7.40 (d, J = 7.6 Hz, 1H), 3.34 (s, 3H), 1.94 (s, 3H). LC-MS (ESI): 376.1. (E)-N-Methyl-N-(3-(1-((3-methyl-4H-1,2,4-triazol-4-yl)imino)ethyl)phenyl) acetamide 6.