IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts

European Journal of Applied Physiology

Volumn 110, Issue 5, 2010, Pages 961-969

  Roberts, Michael D ^a   Dalbo, Vincent J ^b   Sunderland, Kyle L ^a   Poole, Chris N ^a   Hassell, Scott E ^a   Bemben, Debra ^a   Cramer, Joel ^a   Stout, Jeff ^a   Kerksick, Chad M ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b CENTRAL QUEENSLAND UNIVERSITY   (Australia)

Author keywords

Aging; IGF 1EA; MGF; Resistance exercise; Skeletal muscle

Indexed keywords

ISOPROTEIN; SOMATOMEDIN C;

ADOLESCENT; ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BIOSYNTHESIS; CHEMISTRY; EXERCISE; GENE EXPRESSION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; QUADRICEPS FEMORIS MUSCLE; RESISTANCE TRAINING; SKELETAL MUSCLE;

ADOLESCENT; ADULT; AGED; ALTERNATIVE SPLICING; EXERCISE; GENE EXPRESSION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PROTEIN ISOFORMS; QUADRICEPS MUSCLE; RESISTANCE TRAINING; YOUNG ADULT;

EID: 78650522353     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1588-2     Document Type: Article

References (26)

1. Baechle TR, Earle RW (eds) (2000) Essentials of strength and conditioning, 2nd edn. Human Kinetics, Champaign, IL
2. MM Bamman RC Ragan JS Kim JM Cross VJ Hill SC Tuggle RM Allman 2004 Myogenic protein expression before and after resistance loading in 26-and 64-yr-old men and women J Appl Physiol 97 4 1329 1337 1:CAS:528: DC%2BD2cXptFGkt70%3D 10.1152/japplphysiol.01387.2003 15155718 (Pubitemid 39299348)
3. MM Bamman JK Petrella JS Kim DL Mayhew JM Cross 2007 Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans J Appl Physiol 102 6 2232 2239 1:CAS:528:DC%2BD2sXnsVKnu70%3D 10.1152/japplphysiol.00024.2007 17395765 (Pubitemid 47080755)
4. Barton ER, DeMeo J, Lei H (2010) The insulin-like growth factor (IGF)-I E-peptides are required for isoform specific gene expression and muscle hypertrophy after local IGF-I production. J Appl Physiol 108(5):1069-1095
5. A Costa H Dalloul H Hegyesi P Apor Z Csende L Racz M Vaczi J Tihanyi 2007 Impact of repeated bouts of eccentric exercise on myogenic gene expression Eur J Appl Physiol 101 4 427 436 10.1007/s00421-007-0510-z 17641910 (Pubitemid 47500361)
6. DJ Cuthbertson J Babraj K Smith E Wilkes MJ Fedele K Esser M Rennie 2006 Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise Am J Physiol Endocrinol Metab 290 4 E731 E738 1:CAS:528:DC%2BD28Xks1Slsrg%3D 10.1152/ajpendo.00415.2005 16263770
7. RA Dennis H Zhu PM Kortebein HM Bush JF Harvey DH Sullivan CA Peterson 2009 Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes Physiol Genom 38 2 169 175 1:CAS:528:DC%2BC3cXhtlakurfN 10.1152/physiolgenomics.00056.2009
8. MJ Drummond M Miyazaki HC Dreyer B Pennings S Dhanani E Volpi KA Esser BB Rasmussen 2009 Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis J Appl Physiol 106 4 1403 1411 1:CAS:528:DC%2BD1MXltVyhtLs%3D 10.1152/japplphysiol. 90842.2008 18787087
9. G Goldspink 2005 Mechanical signals, IGF-I gene splicing, and muscle adaptation Physiology (Bethesda, MD) 20 232 238 1:CAS:528:DC%2BD2MXpslSmtbc%3D
10. F Haddad GR Adams 2006 Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy J Appl Physiol 100 4 1188 1203 1:CAS:528:DC%2BD28XksFyhsL8%3D 10.1152/japplphysiol.01227.2005 16373446 (Pubitemid 43671476)
11. M Hameed RW Orrell M Cobbold G Goldspink SD Harridge 2003 Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise J Physiol 547 Pt 1 247 254 1:CAS:528:DC%2BD3sXivFSktLo%3D 10.1113/jphysiol.2002.032136 12562960 (Pubitemid 36285178)
12. M Hill G Goldspink 2003 Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage J Physiol 549 Pt 2 409 418 1:CAS:528:DC%2BD3sXlslWnsb8%3D 10.1113/jphysiol.2002.035832 12692175
13. JS Kim JM Cross MM Bamman 2005 Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women Am J Physiol Endocrinol Metab 288 6 E1110 E1119 1:CAS:528:DC%2BD2MXlsVyls7o%3D 10.1152/ajpendo.00464.2004 15644458 (Pubitemid 40726797)
14. WJ Kraemer K Hakkinen RU Newton BC Nindl JS Volek M McCormick LA Gotshalk SE Gordon SJ Fleck WW Campbell M Putukian WJ Evans 1999 Effects of heavy-resistance training on hormonal response patterns in younger vs. older men J Appl Physiol 87 3 982 992 1:CAS:528:DyaK1MXmsVGru7g%3D 10484567
15. V Kumar A Selby D Rankin R Patel P Atherton W Hildebrandt J Williams K Smith O Seynnes N Hiscock MJ Rennie 2009 Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men J Physiol 587 Pt 1 211 217 1:CAS:528:DC%2BD1MXhtVKlsLs%3D 19001042
16. DJ Mahoney K Carey MH Fu R Snow D Cameron-Smith G Parise MA Tarnopolsky 2004 Real-time RT-PCR analysis of housekeeping genes in human skeletal muscle following acute exercise Physiol Genom 18 2 226 231 1:CAS:528: DC%2BD2cXntF2jsbk%3D 10.1152/physiolgenomics.00067.2004 (Pubitemid 39319503)
17. BR McKay CE O'Reilly SM Phillips MA Tarnopolsky G Parise 2008 Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans J Physiol 586 Pt 22 5549 5560 1:CAS:528:DC%2BD1cXhsVKiur7J 10.1113/jphysiol.2008.160176 18818249
18. JK Petrella JS Kim JM Cross DJ Kosek MM Bamman 2006 Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women Am J Physiol Endocrinol Metab 291 5 E937 E946 1:CAS:528:DC%2BD28Xht1Gns7bM 10.1152/ajpendo.00190.2006 16772322
19. JK Petrella JS Kim DL Mayhew JM Cross MM Bamman 2008 Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis J Appl Physiol 104 6 1736 1742 10.1152/japplphysiol.01215.2007 18436694
20. A Philippou E Papageorgiou G Bogdanis A Halapas A Sourla M Maridaki N Pissimissis M Koutsilieris 2009 Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the mgf e peptide actions in vitro In Vivo (Athens, Greece) 23 4 567 575 1:CAS:528: DC%2BD1MXpsFaqs7Y%3D
21. N Psilander R Damsgaard H Pilegaard 2003 Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle J Appl Physiol 95 3 1038 1044 1:CAS:528:DC%2BD3sXnsFCjsbk%3D 12716875
22. Roberts MD, Dalbo VJ, Hassell SE, Kerksick CM (2010) Effects of pre-exercise feeding on markers of satellite cell activation. Med Sci Sports Exerc (in press)
23. C Rommel SC Bodine BA Clarke R Rossman L Nunez TN Stitt GD Yancopoulos DJ Glass 2001 Mediation of IGF-1-induced skeletal myotube hypertrophy by pi(3)k/akt/mtor and pi(3)k/akt/gsk3 pathways Nat Cell Biol 3 11 1009 1013 1:CAS:528:DC%2BD3MXosVeqt7w%3D 10.1038/ncb1101-1009 11715022 (Pubitemid 34428746)
24. AE Thalacker-Mercer JC Fleet BA Craig NS Carnell WW Campbell 2007 Inadequate protein intake affects skeletal muscle transcript profiles in older humans Am J Clin Nutr 85 5 1344 1352 1:CAS:528:DC%2BD2sXls1Khs74%3D 17490972
25. LB Verdijk BG Gleeson RA Jonkers K Meijer HH Savelberg P Dendale LJ van Loon 2009 Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men J Gerontol 64 3 332 339
26. S Welle K Bhatt CA Thornton 2000 High-abundance mRNAs in human muscle: comparison between young and old J Appl Physiol 89 1 297 304 1:CAS:528:DC%2BD3cXlslGju78%3D 10904065