Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [11C] methylated LY2181308

Molecular Imaging and Biology

Volumn 12, Issue 6, 2010, Pages 608-615

  Dence, Carmen S ^a   Laforest, Richard ^a   Sun, Xiankai ^a   Sharp, Terry L ^a   Welch, Michael J ^a   MacH, Robert H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon 11; Dosimetry; Oligonucleotides; PET; Tumor uptake

Indexed keywords

BIOLOGICAL MARKER; CARBON METHYLATED LY 2181308 C 11; LY 2181308; METHYL IODIDE; RADIOPHARMACEUTICAL AGENT; SURVIVIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BABOON; BREAST CANCER; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOSIMETRY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; ISOTOPE LABELING; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RADIOASSAY; RAT; REPRODUCIBILITY; TUMOR MODEL; WHOLE BODY PET;

ADULT; ANIMALS; CARBON RADIOISOTOPES; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; NEOPLASMS; OLIGONUCLEOTIDES; PAPIO; RADIATION DOSAGE; RADIOMETRY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RODENTIA; TISSUE DISTRIBUTION;

MUS; PAPIO; RATTUS; RODENTIA;

EID: 78650517413     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0319-8     Document Type: Article

References (17)

1. G Ambrosini C Adida DC Altieri 1997 A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma Nat Med 3 917 921 1:CAS:528:DyaK2sXltVylt7w%3D 10.1038/nm0897-917 9256286 (Pubitemid 27353455)
2. DC Altieri 2001 The molecular basis and potential role of survivin in cancer diagnosis and therapy Rev Trends Mol Med 7 542 547 1:CAS:528: DC%2BD3MXovVCnu70%3D 10.1016/S1471-4914(01)02243-2 (Pubitemid 33127139)
3. N Zaffaroni MG Daidone 2002 Survivin expression and resistance to anticancer treatments: perspective for new therapeutic interventions Drug Resist Updat (review) 5 65 72 1:CAS:528:DC%2BD38XosFKjurg%3D 10.1016/S1368-7646(02) 00049-3 (Pubitemid 35033448)
4. MJ Kallio M Nieminen JE Eriksson 2001 Human inhibitor of apoptosis protein (IAP) survivin participates in regulation of chromosome segregation and mitotic exit FASEB J 15 2721 2723 1:CAS:528:DC%2BD3MXptFags7s%3D 11687505
5. F Li G Ambrosini EY Chu, et al. 1998 Control of apoptosis and mitotic spindle checkpoint by survivin Nature 396 580 584 1:CAS:528:DyaK1cXotVWns70%3D 10.1038/25141 9859993 (Pubitemid 28563719)
6. RA Olie P Simoes-Wust B Baumann, et al. 2000 A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy Cancer Res 60 2805 2809 1:CAS:528: DC%2BD3cXjvFOlsLo%3D 10850418 (Pubitemid 30395796)
7. CK Younes R Boisgard B Tavitian 2002 Labelled oligonucleotides as radiopharmaceuticals: pitfalls, problems and perspectives Curr Pharm Des 8 1451 1466 1:CAS:528:DC%2BD38XkvVWlu7c%3D 10.2174/1381612023394467 12052206 (Pubitemid 34693063)
8. F Dolle F Hinnen F Vaufrey, et al. 1997 A general method for labeling oligodeoxynucleotides with F-18 for in vivo PET imaging J Labl Comp Radiopharm 39 319 330 1:CAS:528:DyaK2sXislaisr4%3D 10.1002/(SICI)1099-1344(199704)39: 4<319::AID-JLCR970>3.0.CO;2-7 (Pubitemid 27149924)
9. B Tavitian S Terrazzino B Kuhnast, et al. 1998 In vivo imaging of oligonucleotides with positron emission tomography Nature Med 4 467 471 1:CAS:528:DyaK1cXisVektr8%3D 10.1038/nm0498-467 9546795 (Pubitemid 28212765)
10. 11C]-methylated LY2181308, an antisense oligonucleotide to survivin: radiochemical synthesis and preliminary rodent biodistribution studies J Labl Comp Radiopharm 48 S161
11. 11C]- methylated LY2181308, an antisense oligonucleotide to survivin: part II-human dosimetry calculation J Labl Comp Radiopharm 50 S449
12. A Saleem M Ranson S Callies M Lahn C Prenant G Brown JC Mathews CS Dence A McMahon P Price 2009 Microdosing imaging pharmacokinetic (PK) study of the anti-sense oligonucleotide (ASO) to Survivin (LY 2181308) using positron emission tomography (PET): a novel paradigm in clinical drug development J Clin Oncol 27 15S 3578
13. USP 32-NF 27 (2009) First supplement chapter <467>
14. ZA Iskandar FS Al-Joudi 2006 Expression of survivin in fetal and adult normal tissue of rat Malaysian J Pathol 28 101 106 1:STN:280: DC%2BD1c3hvVyktg%3D%3D
15. DM Sohn SY Kim MJ Baek, et al. 2006 Expression of survivin and clinical correlation in patients with breast cancer Biomed Pharmacotherapy 60 289 292 1:CAS:528:DC%2BD28XotlWmsL0%3D 10.1016/j.biopha.2006.06.008 (Pubitemid 44223940)
16. SM Kennedy L O'Driscoll R Purcell, et al. 2003 Prognostic importance of survivin in breast cancer Br J Cancer 88 1077 1083 1:CAS:528: DC%2BD3sXisFahsLs%3D 10.1038/sj.bjc.6600776 12671708 (Pubitemid 36560779)
17. K Tanaka S Iwamoto G Gon, et al. 2000 Expression of survivin and its relationship to loss of apoptosis in breast carcinomas Clin Cancer Res 6 127 134 1:CAS:528:DC%2BD3cXhtVCjsr4%3D 10656440 (Pubitemid 30064984)