Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 475-478

  Yao, Zhiyi ^a   Xu, Yingjun ^a   Zhang, Minmin ^a   Jiang, Sheng ^a   Nicklaus, Marc C ^b   Liao, Chenzhong ^b,c  

^a SHANGHAI INSTITUTE OF TECHNOLOGY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NANKAI UNIVERSITY   (China)

Author keywords

5 reductase inhibitor; Combination principles; Epristeride; Finasteride; Hybrid

Indexed keywords

EPRISTERIDE; FINASTERIDE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 5-ALPHA REDUCTASE INHIBITORS; ANDROSTADIENES; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; FINASTERIDE; HUMANS;

EID: 78650516480     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.112     Document Type: Article

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