N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 186-190

  Zimmer, Christina ^a   Hafner, Marieke ^a   Zender, Michael ^a   Ammann, Dominic ^a   Hartmann, Rolf W ^a   Vock, Carsten A ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aldosterone; Aldosterone synthase; Congestive heart failure; CYP11B2; Metyrapone; Myocardial fibrosis; Selective inhibition

Indexed keywords

ALDOSTERONE SYNTHASE INHIBITOR; ENZYME INHIBITOR; N (PYRIDIN 3 YL)BENZAMIDE DERIVATIVE; STEROID 11BETA MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

ALDOSTERONE SYNTHASE; AROMATASE; BENZAMIDES; ENZYME INHIBITORS; HUMANS; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650514131     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.040     Document Type: Article

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