Changes in transferrin glycosylation during pregnancy may lead to false-positive carbohydrate-deficient transferrin (CDT) results in testing for riskful alcohol consumption

Clinica Chimica Acta

Volumn 412, Issue 1-2, 2011, Pages 129-133

  Kenan, Naama ^a   Larsson, Anders ^b   Axelsson, Ove ^b   Helander, Anders ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alcohol biomarker; Carbohydrate deficient transferrin; High performance liquid chromatography; Pregnancy; Transferrin glycosylation

Indexed keywords

BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; SIALOPROTEIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATTITUDE TO PREGNANCY; BLOOD ANALYSIS; CONTROLLED STUDY; DRINKING BEHAVIOR; FALSE POSITIVE RESULT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NORMAL HUMAN; NORMAL VALUE; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN GLYCOSYLATION; PUERPERIUM; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RISK REDUCTION; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY; TRANSFERRIN BLOOD LEVEL;

ADULT; ALCOHOL DRINKING; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FALSE POSITIVE REACTIONS; FEMALE; GLYCOSYLATION; HUMANS; POSTPARTUM PERIOD; PREGNANCY; REFERENCE STANDARDS; RISK; TRANSFERRIN; YOUNG ADULT;

EID: 78650513424     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.09.022     Document Type: Article

References (40)

1. Lockitch G. Clinical biochemistry of pregnancy. Crit Rev Clin Lab Sci 1997, 34:67-139.
2. Larsson A., Palm M., Hansson L.O., Axelsson O. Reference values for clinical chemistry tests during normal pregnancy. BJOG 2008, 115:874-881.
3. Larsson A., Palm M., Hansson L.O., Basu S., Axelsson O. Reference values for alpha1-acid glycoprotein, alpha1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy. Acta Obstet Gynecol Scand 2008, 87:1084-1088.
4. Abbassi-Ghanavati M., Greer L.G., Cunningham F.G. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol 2009, 114:1326-1331.
5. Leger D., Campion B., Decottignies J.P., Montreuil J., Spik G. Physiological significance of the marked increased branching of the glycans of human serotransferrin during pregnancy. Biochem J 1989, 257:231-238.
6. de Jong G., van Dijk J.P., van Eijk H.G. The biology of transferrin. Clin Chim Acta 1990, 190:1-46.
7. Bergström J.P., Helander A. Influence of alcohol use, ethnicity, age, gender, BMI and smoking on the serum transferrin glycoform pattern: implications for use of carbohydrate-deficient transferrin (CDT) as alcohol biomarker. Clin Chim Acta 2008, 388:59-67.
8. Helander A., Husa A., Jeppsson J.-O. Improved HPLC method for carbohydrate-deficient transferrin in serum. Clin Chem 2003, 49:1881-1890.
9. de Jong G., van Eijk H.G. Microheterogeneity of human serum transferrin: a biological phenomenon studied by isoelectric focusing in immobilized pH gradients. Electrophoresis 1988, 9:589-598.
10. Wu Y., Sakamoto H., Kanenishi K., Tanaka S., Ueno M., Hata T. Transferrin microheterogeneity in fetal blood. Biol Neonate 2004, 86:98-103.
11. Helander A., Carlsson S. Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy. Alcohol Clin Exp Res 1996, 20:1202-1205.
12. Jeppsson J.O., Kristensson H., Fimiani C. Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clin Chem 1993, 39:2115-2120.
13. Jeppsson J.O., Arndt T., Schellenberg F., et al. Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method. Clin Chem Lab Med 2007, 45:558-562.
14. Stibler H. Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin Chem 1991, 37:2029-2037.
15. Arndt T. Carbohydrate-deficient transferrin as a marker of chronic alcohol abuse: a critical review of preanalysis, analysis, and interpretation. Clin Chem 2001, 47:13-27.
16. Bortolotti F., De Paoli G., Tagliaro F. Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: a critical review of the literature 2001-2005. J Chromatogr B Anal Technol Biomed Life Sci 2006, 841:96-109.
17. Golka K., Wiese A. Carbohydrate-deficient transferrin (CDT) - a biomarker for long-term alcohol consumption. J Toxicol Environ Health B Crit Rev 2004, 7:319-337.
18. Bergström J.P., Helander A. HPLC evaluation of clinical and pharmacological factors reported to cause false-positive carbohydrate-deficient transferrin (CDT) levels. Clin Chim Acta 2008, 389:164-166.
19. Sarkola T., Eriksson C.J., Niemelä O., Sillanaukee P., Halmesmäki E. Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. Acta Obstet Gynecol Scand 2000, 79:359-366.
20. Stauber R.E., Jauk B., Fickert P., Hausler M. Increased carbohydrate-deficient transferrin during pregnancy: relation to sex hormones. Alcohol Alcohol 1996, 31:389-392.
21. Bean P., Liegmann K., Løvli T., Westby C., Sundrehagen E. Semiautomated procedures for evaluation of carbohydrate-deficient transferrin in the diagnosis of alcohol abuse. Clin Chem 1997, 43:983-989.
22. Stauber R.E., Jauk B., Fickert P., Hausler M. Effect of pregnancy on carbohydrate-deficient transferrin: absolute or relative values? Reply. Alcohol Alcohol 1997, 32:537-538.
23. Helander A., Nordin G. Insufficient standardization of a direct carbohydrate-deficient transferrin immunoassay. Clin Chem 2008, 54:1090-1092.
24. Mårtensson O., Schink E., Brandt R. Diurnal variability and in vitro stability of carbohydrate-deficient transferrin. Clin Chem 1998, 44:2226-2227.
25. Bergström J.P., Helander A. Clinical characteristics of carbohydrate-deficient transferrin (%disialotransferrin) measured by HPLC: sensitivity, specificity, gender effects, and relationship with other alcohol biomarkers. Alcohol Alcohol 2008, 43:436-441.
26. Floyd R.L., O'Connor M.J., Sokol R.J., Bertrand J., Cordero J.F. Recognition and prevention of fetal alcohol syndrome. Obstet Gynecol 2005, 106:1059-1064.
27. Ismail S., Buckley S., Budacki R., Jabbar A., Gallicano G.I. Screening, diagnosing and prevention of fetal alcohol syndrome: is this syndrome treatable?. Dev Neurosci 2010, 32:91-100.
28. Helander A., von Wachenfeldt J., Hiltunen A., Beck O., Liljeberg P., Borg S. Comparison of urinary 5-hydroxytryptophol, breath ethanol, and self-report for detection of recent alcohol use during outpatient treatment: a study on methadone patients. Drug Alcohol Depend 1999, 56:33-38.
29. Cook J.D. Biochemical markers of alcohol use in pregnant women. Clin Biochem 2003, 36:9-19.
30. Hannuksela M.L., Liisanantti M.K., Nissinen A.E., Savolainen M.J. Biochemical markers of alcoholism. Clin Chem Lab Med 2007, 45:953-961.
31. Littner Y., Bearer C.F. Detection of alcohol consumption during pregnancy - current and future biomarkers. Neurosci Biobehav Rev 2007, 31:261-269.
32. Burd L., Hofer R. Biomarkers for detection of prenatal alcohol exposure: a critical review of fatty acid ethyl esters in meconium. Birth Defects Res A Clin Mol Teratol 2008, 82:487-493.
33. Pragst F., Yegles M. Determination of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in hair: a promising way for retrospective detection of alcohol abuse during pregnancy?. Ther Drug Monit 2008, 30:255-263.
34. Helander A., Eriksson G., Stibler H., Jeppsson J.-O. Interference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse. Clin Chem 2001, 47:1225-1233.
35. Helander A., Bergström J., Freeze H.H. Testing for congenital disorders of glycosylation by HPLC measurement of serum transferrin glycoforms. Clin Chem 2004, 50:954-958.
36. Arndt T., van der Meijden B.B., Wielders J.P. Atypical serum transferrin isoform distribution in liver cirrhosis studied by HPLC, capillary electrophoresis and transferrin genotyping. Clin Chim Acta 2008, 394:42-46.
37. Stewart SH, Comte-Walters S, Bowen E, Anton RF. Liver disease and HPLC quantification of disialotransferrin for heavy alcohol use: a case series. Alcohol Clin Exp Res 2010 [Electronic publication ahead of print]. doi:10.1111/j.1530-0277.2010.01285.x.
38. Fleming M.F., Anton R.F., Spies C.D. A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels. Alcohol Clin Exp Res 2004, 28:1347-1355.
39. Löf K., Seppä K., Itala L., Koivula T., Turpeinen U., Sillanaukee P. Carbohydrate-deficient transferrin as an alcohol marker among female heavy drinkers: a population-based study. Alcohol Clin Exp Res 1994, 18:889-894.
40. Sillanaukee P., Alho H., Strid N., Jousilahti P., Vartiainen E., Olsson U. Effect of hormone balance on carbohydrate-deficient transferrin and gamma-glutamyltransferase in female social drinkers. Alcohol Clin Exp Res 2000, 24:1505-1509.