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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 484-487

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

(14) Boyd, Michael J a Berthelette, Carl a Chiasson, Jean Franois a Clark, Patsy a Colucci, John a Denis, Danielle a Han, Yongxin a Lévesque, Jean Francois a Mathieu, Marie Claude a Stocco, Rino a Therien, Alex a Rowland, Steve a Wrona, Mark a Xu, Daigen a

a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

EP4; Inflammation; Prostaglandin E2

Indexed keywords

INDOLE DERIVATIVE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERALGESIA; NONHUMAN; RAT;

ANIMALS; ARTHRITIS; DRUG EVALUATION, PRECLINICAL; HYPERALGESIA; INDOLES; LIGANDS; RATS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 78650511351 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.10.106 Document Type: Article

Times cited : (18)

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