A rapid computational filter for predicting the rate of human renal clearance

Journal of Molecular Graphics and Modelling

Volumn 29, Issue 4, 2010, Pages 529-537

  Paine, Stuart W ^a   Barton, Patrick ^a   Bird, James ^a   Denton, Rebecca ^a   Menochet, Karelle ^b   Smith, Aaron ^a   Tomkinson, Nicholas P ^a   Chohan, Kamaldeep K ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Classification And Regression Trees (CART); Human renal clearance; Partial Least Squares (PLS); Quantitative structure activity relationship (QSAR); Random Forest (RF)

Indexed keywords

CLASSIFICATION AND REGRESSION TREE; PARTIAL LEAST SQUARES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS; RANDOM FORESTS; RENAL CLEARANCE;

BIOCHEMISTRY; DECISION TREES; REGRESSION ANALYSIS;

FORECASTING;

ION;

ARTICLE; KIDNEY CLEARANCE; LIPOPHILICITY; PARTIAL LEAST SQUARES REGRESSION; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOM FOREST;

BLOOD PROTEINS; COMPUTER SIMULATION; HUMANS; KIDNEY; LEAST-SQUARES ANALYSIS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS;

EID: 78650509649     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2010.10.003     Document Type: Article

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