Penetration of topically applied diclofenac and ketorolac into the aqueous humour and subretinal fluid: Randomized clinical trial

Canadian Journal of Ophthalmology

Volumn 45, Issue 6, 2010, Pages 610-615

  Unlu, Nurten ^a   Kocaoglan, Hulya ^a   Sayin, Filiz ^b   Hazirolan, Dicle ^a   Demircan, Seyda ^b   Basci, Nursabah ^b   Acar, Mehmet A ^a   Demir, Necati M ^a   Duman, Sunay ^a  

^a MINISTRY OF HEALTH   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Aqueous humour; Diclofenac sodium 0.1 ; Ketorolac tromethamine 0.5 ; Subretinal fluid

Indexed keywords

DICLOFENAC; KETOROLAC TROMETAMOL;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG PENETRATION; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; RETINA SURGERY; SUBRETINAL FLUID;

EID: 78650503265     PISSN: 00084182     EISSN: 17153360     Source Type: Journal    
DOI: 10.3129/i10-048     Document Type: Article

References (18)

1. Tognetto D, Cecchini P, Sanguinetti G, Pedio M, Ravalico G. Comparative evaluation of corneal epithelial permeability after the use of diclofenac 0.1% and flurbiprofen 0.03% after phacoemulsification. J Cataract Refract Surg 2001;27:1392-6.
2. Kocak I, Yalvac IS, Kocak A, et al. Comparison of the antiinflammatory effects of diclofenac and flurbiprofen eye drops after cataract extraction. Acta Ophthalmol Scand 1998; 76:343-5.
3. Kraff MC, Martin RG, Neumann AC, Weinstein AJ. Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. J Cataract Refract Surg 1994;20:138-44.
4. Rho DS. Treatment of acute pseudophakic cystoid macular edema: diclofenac versus ketorolac. J Cataract Refract Surg 2003;29:2378-84.
5. Srinivasan R, Madhavaranga. Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. J Cataract Refract Surg 2002;28:517-20.
6. International Conference on Harmonisation, Expert Working Group. ICH Harmonised Tripartite Guideline. Validation of analytical procedures: text and methodology Q2 (R1). ICH Steering Committee, 2005.
7. Hughes PM, Olejnik O, Chang-Lin JE, Wilson CG. Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev 2005;57:2010-32.
8. Weijtens O, Schoemaker RC, Lentjes EGWM, Romijn FP, Cohen AF, van Meurs JC. Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose. Ophthalmology 2000; 107:1932-8.
9. Weijtens O, van der Sluijs FA, Schoemaker RC, et al. Peribulbar corticosteroid injection: vitreal and serum concentration after dexamethasone disodium phosphate injection. Am J Ophthalmol 1997;123:358-63.
10. Miyake K. Indomethacine in the treatment of postoperative cystoid macular edema. Surv Ophthalmol 1984;28:554-68.
11. Starks WJ Jr, Maumence AE, FagadauW, et al. Cystoid macular edema in pseudophakia. Surv Ophthalmol 1984;28:442-51.
12. Miyake K, Masuda K, Shirato S, et al. Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: a multicentered prospective trial. Jpn J Ophthalmol 2000;44:58-67.
13. Rossetti L, Bujtar E, Castoldi D, Torrazza C, Orzalesi N. Effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of cystoid macular edema after cataract surgery. J Cataract Refract Surg 1996;22:794-9.
14. Italian Diclofenac Study Group. Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-termcystoid macular edema. J Cataract Refract Surg 1997;23:1183-9.
15. Flach AJ, Jampol LM, Weinberg D, et al. Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine. Am J Ophthalmol 1991;112:514-9.
16. Palmero M, Bellot JL, Alcoriza N, Garcia-Cabanes C, Orts A. The ocular pharmacokinetics of topical diclofenac is affected by ocular inflammation. Ophthalmic Res 1999;31:309-16.
17. Rabiah PK, Fiscella RG, Tessler HH. Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. Invest Ophthalmol Vis Sci 1996;37:613-8.
18. Hessemer V, Schmitt K, Jacobi A. Anti-inflammatory effects and aqueous humor concentration of various anti-inflammatory drugs in extracapsular cataract surgery. Klin Monatsbl Augenheilkd 1996;208:161-6.