Stroke thrombolysis in England, Wales and Northern Ireland: How much do we do and how much do we need?

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 82, Issue 1, 2011, Pages 14-19

  Rudd, A G ^a,b   Hoffman, A ^a   Grant, R ^a   Campbell, J T ^a   Lowe, D ^a  

^a ROYAL COLLEGE OF PHYSICIANS   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN INFARCTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STROKE; STROKE PATIENT; SYMPTOM; TREATMENT INDICATION; TREATMENT OUTCOME; UNITED KINGDOM;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; AMBULANCES; DIAGNOSIS-RELATED GROUPS; ELIGIBILITY DETERMINATION; ENGLAND; FEMALE; FIBRINOLYTIC AGENTS; HOSPITAL MORTALITY; HOSPITALS; HUMANS; MALE; MIDDLE AGED; NORTHERN IRELAND; PATIENT ADMISSION; PLASMINOGEN ACTIVATORS; SEX FACTORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; WALES;

EID: 78650499833     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2009.203174     Document Type: Article

References (29)

1. Wardlaw JM, del Zoppo G, Yamaguchi T. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2000;2:CD000213. Update in: Cochrane Database Syst Rev 2003;3:CD000213.
2. Hacke W, Kaste M, Bluhmki E, et al. Toni D for the ECASS investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischaemic stroke. N Engl J Med 2008;359:1317-29.
3. Wahlgren N, Ahmed N, Dávalos A, et al. SITS-MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): An observational study. Lancet 2007;369:275-82.
4. Katzan IL, Furlan AJ, Lloyd LE, et al. Use of tissue-type plasminogen activator for acute ischaemic stroke: The Cleveland area experience. JAMA 2000;282:1151-8.
5. Heuschmann PU, Berger K Misselwitz B, Hermanek P. For the German Stroke Registers Study Group. Frequency of thrombolytic therapy in patients with acute ischaemic stroke and the risk of in-hospital mortality. Stroke 2003;34:1106-13.
6. Bray JE, Coughlan K, Bladin C. Thrombolysis therapy for acute ischaemic stroke: Successful implementation in an Australian tertiary hospital. Intern Med J 2006;36:483-8.
7. Steiner MM, Brainin M; Austrian Stroke Registry for Acute Stroke Units. The quality of acute stroke units on a nation-wide level: The Austrian Stroke Registry for acute stroke units. Eur J Neurol 2003;10:353-60.
8. Royal College of Physicians. National Sentinel Stroke Audit. Clinical audit. London: Royal College of Physicians, 2006. http://www.rcplondon.ac.uk/ clinical-standards/ ceeu/Current-work/Documents/ Public%20organisational%20report2008.pdf.
9. Walters MR, Muir KW, Harbison J, et al. Intravenous thrombolysis for acute ischaemic stroke: Preliminary experience with recombinant tissue plasminogen activator in the UK. Cerebrovasc Dis 2005;20:438-42.
10. Department of Health. National Stroke Strategy. London: Department of Health, 2007. http://www.dh.gov.uk/publications.
11. Anon. NICE Guideline on Diagnosis and Initial Management of Acute Stroke and TIA. 2008. http://www.nice.org.uk/nicemedia/pdf/CG68FullGuideline.pdf.
12. Anon. NICE Technology Appraisal Alteplase TA122. 2007. http://www.nice.org.uk/ Guidance/TA122.
13. Royal College of Physicians. National sentinel stroke audit. Clinical audit. London: Royal College of Physicians, 2008. http://www.rcplondon.ac.uk/ clinical-standards/ ceeu/Current-work/Documents/.
14. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischaemic stroke. N Engl J Med 1995;333:1581-7.
15. Reed SD, Cramer SC, Blough DK, et al. Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischaemic stroke treated in community hospitals. Stroke 2001;32:1832-40.
16. Johnston SC, Fung LH, Gillum LA, et al. Utilization of intravenous tissue-type plasminogen activator for ischaemic stroke at academic medical centres; the influence of ethnicity. Stroke 2001;32:1061-8.
17. Barber PA, Zhang J, Demchuk AM, et al. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology 2001;56:1015-20.
18. Demaerschalk BM, Bobrow BJ, Paulsen M. Development of a metropolitan matrix of primary stroke centres: The phoenix experience. Stroke 2008;39:1246-53.
19. Jørgensen HS, Nakayama H, Kammersgaard LP, et al. Predicted impact of intravenous thrombolysis on prognosis of general population of stroke patients: Simulation model. BMJ 1999;319:288-9.
20. Kleindorfer D, Kissela B, Schneider A, et al. Neuroscience Institute. Eligibility for recombinant tissue plasminogen activator in acute ischaemic stroke: A population based study. Stroke 2004;35:e27-9.
21. Boode B, Welzen V, Franke C, et al. Estimating the number of stroke patients eligible for thrombolytic therapy if delay could be avoided. Cerebrovasc Dis 2007;23:294-8.
22. Ford GA, Nor AM, McAllister C, et al. Agreement between ambulance paramedicand physician-recorded neurological signs with Face Arm Speech Test (FAST) in acute stroke patients. Stroke 2004;35:1355-9.
23. Quain DA, Parsons MW, Loudfoot AR, et al. Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care. Med J Aust 2008;189:429-33.
24. Wojner-Alexandrov AW, Alexandrov AV, Rodriguez D, et al. Houston paramedic and emergency stroke treatment and outcomes study (HoPSTO). Stroke 2005;36:1512-18.
25. Lichtman JH, Watanabe E, Allen NB, et al. Hospital arrival time and intravenous t-PA use in US Academic Medical Centers, 2001-2004. Stroke 2009;40:3845-50.
26. Heuschmann PU, Kolominsky-Rabas PI, Roether J, et al. for the German Stroke Registers Study Group. Predictors of in-hospital mortality in patients with acute ischaemic stroke treated with thrombolytic therapy. JAMA 2004;292:1831-8.
27. Intercollegiate Stroke Working Party. National Sentinel Audit of Stroke Organisation of Stroke Care in England, Wales and Northern Ireland, 2009. http://www.rcplondon.ac.uk/stroke.
28. Intercollegiate Stroke Working Party. National Sentinel Audit of Stroke Organisation of Stroke Care in England, Wales and Northern Ireland. 2008. http://www.rcplondon.ac.uk/stroke.
29. Rudd AG, Hoffman A, Irwin P, et al. Stroke units: Research and reality. Results from the National Sentinel Audit of Stroke. Qual Saf Health Care 2005;14:7-12.