Dermatophytes: Host-pathogen interaction and antifungal resistance;Dermatófitos: Interação patógeno-hospedeiro e resistência a antifúngicos

Anais Brasileiros de Dermatologia

Volumn 85, Issue 5, 2010, Pages 657-667

  De Aguiar Peres, Nalu Teixera ^a,b   Maranhão, Fernanda Cristina Albuquerque ^a,c   Rossi, Antonio ^a   Martinez Rossi, Nilce Maria ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Food Research Center FoRC   (Brazil)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Antifungal agents; Dermatomycoses; Drug resistance, fungal; Host pathogen interactions

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ACRIFLAVINE; AMOROLFINE; AMPHOTERICIN B; BENOMYL; BUTENAFINE; CICLOPIROX; ENILCONAZOLE; ETHIDIUM BROMIDE; FLUCONAZOLE; GRISEOFULVIN; ITRACONAZOLE; KETOCONAZOLE; NAFTIFINE; TERBINAFINE; TIOCONAZOLE; TOLCICLATE; UNDECANOIC ACID;

ANTIFUNGAL RESISTANCE; DERMATOPHYTE; DERMATOPHYTOSIS; DRUG MECHANISM; HOST PATHOGEN INTERACTION; INFECTION CONTROL; ONYCHOMYCOSIS; PATHOGENESIS; REVIEW; TRICHOPHYTON RUBRUM; TRICHOPHYTOSIS;

EID: 78650470868     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/s0365-05962010000500009     Document Type: Review

References (46)

1. White TC, Oliver BG, Graser Y, Henn MR. Generating and testing molecular hypotheses in the dermatophytes. Eukaryot Cell. 2008;7:1238-45.
2. Degreef H. Clinical forms of dermatophytosis (ringworm infection). Mycopathologia. 2008;166:257-65.
3. Rodwell GE, Bayles CL, Towersey L, Aly R. The prevalence of dermatophyte infection in patients infected with human immunodeficiency virus. Int J Dermatol. 2008;47:339-43.
4. Seebacher C, Bouchara J P, Mignon B. Updates on the epidemiology of dermatophyte infections. Mycopathologia. 2008;166:335-52.
5. Clemons K V, Stover E P, Schar G, Stathis PA, Chan K, Tokes L, et al. Steroid metabolism as a mechanism of escape from progesterone-mediated growth inhibition in Trichophyton mentagrophytes. J Biol Chem. 1989;264:11186-92.
6. Burzykowski T, Molenberghs G, Abeck D, Haneke E, Hay R, Katsambas A, et al. High prevalence of foot diseases in Europe: results of the Achilles Project. Mycoses. 2003;46:496-505.
7. Abdel-Rahman SM, Simon S, Wright KJ, Ndjountche L, Gaedigk A. Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing. Pediatrics. 2006;118:2365-73.
8. Purim KS, de Freitas CF, Leite N. Feet dermatophytosis in soccer players. An Bras Dermatol. 2009;84:550-2.
9. Aquino VR, Constante CC, Bakos L. Frequency of dermatophytosis in mycological examinations at a general hospital in Porto Alegre, Brazil. An Bras Dermatol. 2007;82:239-44.
10. Moraes MS, Godoy-Martinez P, Alchorne MM, Boatto HF, Fischman O. Incidence of Tinea capitis in Sao Paulo, Brazil. Mycopathologia. 2006;162:91-5.
11. Siqueira ER, Ferreira JC, Maffei CM, Candido RC. [Occurrence of dermatophyte, in nails, feet and hands of university students]. Rev Soc Bras Med Trop. 2006;39:269-71.
12. Godoy-Martinez P, Nunes FG, Tomimori-Yamashita J, Urrutia M, Zaror L, Silva V, et al. Onychomycosis in Sao Paulo, Brazil. Mycopathologia. 2009;168:111-6.
13. Brilhante RS, Cordeiro RA, Medrano DJ, Rocha MF, Monteiro AJ, Cavalcante CS, et al. Onychomycosis in Ceara (Northeast Brazil): epidemiological and laboratory aspects. Mem Inst Oswaldo Cruz. 2005;100:131-5.
14. Wagner DK, Sohnle PG. Cutaneous defenses against dermatophytes and yeasts. Clin Microbiol Rev. 1995;8:317-35.
15. Vermout S, Tabart J, Baldo A, Mathy A, Losson B, Mignon B. Pathogenesis of dermatophytosis. Mycopathologia. 2008;166:267-75.
16. Kaufman G, Horwitz BA, Duek L, Ullman Y, Berdicevsky I. Infection stages of the dermatophyte pathogen Trichophyton: microscopic characterization and proteolytic enzymes. Med Mycol. 2007;45:149-55.
17. Esquenazi D, Alviano CS, de Souza W, Rozental S. The influence of surface carbohydrates during in vitro infection of mammalian cells by the dermatophyte Trichophyton rubrum. Res Microbiol. 2004;155:144-53.
18. Esquenazi D, de Souza W, Alviano CS, Rozental S. The role of surface carbohydrates on the interaction of microconidia of Trichophyton mentagrophytes with epithelial cells. FEMS Immunol Med Microbiol. 2003;35:113-23.
19. Leng W, Liu T, Wang J, Li R, Jin Q. Expression dynamics of secreted protease genes in Trichophyton rubrum induced by key host's proteinaceous components. Med Mycol. 2008;1-7.
20. Brouta F, Descamps F, Monod M, Vermout S, Losson B, Mignon B. Secreted metalloprotease gene family of Microsporum canis. Infect Immun. 2002;70:5676-83.
21. Fraser RD, Parry DA. The three-dimensional structure of trichocyte (hard alpha-) keratin intermediate filaments: features of the molecular packing deduced from the sites of induced crosslinks. J Struct Biol. 2005;151:171-81.
22. Lechenne B, Reichard U, Zaugg C, Fratti M, Kunert J, Boulat O, et al. Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes. Microbiology. 2007;153:905-13.
23. Baldo A, Tabart J, Vermout S, Mathy A, Collard A, Losson B, et al. Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes. J Med Microbiol. 2008;57:1152-6.
24. Vermout S, Baldo A, Tabart J, Losson B, Mignon B. Secreted dipeptidyl peptidases as potential virulence factors for Microsporum canis. FEMS Immunol Med Microbiol. 2008;54:299-308.
25. Tsuboi R, Ko IJ, Takamori K, Ogawa H. Isolation of a keratinolytic proteinase from Trichophyton mentagrophytes with enzymatic activity at acidic pH. Infect Immun. 1989;57:3479-83.
26. Martinez-Rossi NM, Ferreira-Nozawa MS, Graminha MAS, Nozawa SR, Fachin AL, Cervelatti E P, et al. Molecular aspects of dermatophyte-host interactions. In: Kushwaha RKS, ed. Fungi in human and animal health. Jodhpur, India: Scientific Publishers Jodhpur; 2004. p. 143-65.
27. Maranhão FCA, Paião FG, Martinez-Rossi NM. Isolation of transcripts over-expressed in human pathogen Trichophyton rubrum during growth in keratin. Microb Pathog. 2007;43:166-72.
28. Silveira HCS, Gras DE, Cazzaniga RA, Sanches PR, Rossi A, Martinez-Rossi NM. Transcriptional profiling reveals genes in the human pathogen Trichophyton rubrum that are expressed in response to pH signaling. Microb Pathog. 2010;48:91-6.
29. Ferreira-Nozawa MS, Silveira HCS, Ono CJ, Fachin AL, Rossi A, Martinez-Rossi NM. The pH signaling transcription factor PacC mediates the growth of Trichophyton rubrum on human nail in vitro. Med Mycol. 2006;44:641-5.
30. Muhsin TM, Aubaid AH, al-Duboon AH. Extracellular enzyme activities of dermatophytes and yeast isolates on solid media. Mycoses. 1997;40:465-9.
31. Tani K, Adachi M, Nakamura Y, Kano R, Makimura K, Hasegawa A, et al. The effect of dermatophytes on cytokine production by human keratinocytes. Arch Dermatol Res. 2007;299:381-7.
32. Ogawa H, Summerbell RC, Clemons K V, Koga T, Ran Y P, Rashid A, et al. Dermatophytes and host defense in cutaneous mycoses. Med Mycol. 1998;36:166-73.
33. Shiraki Y, Ishibashi Y, Hiruma M, Nishikawa A, Ikeda S. Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections. J Med Microbiol. 2006;55:1175-85.
34. Blake JS, Dahl M V, Herron MJ, Nelson RD. An immunoinhibitory cell wall glycoprotein (mannan) from Trichophyton rubrum. J Invest Dermatol. 1991;96:657-61.
35. Peres NTA, Sanches PR, Falcão J P, Silveira HCS, Paião FG, Maranhão FCA, et al. Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum. BMC Microbiol. 2010;10:39.
36. Zaugg C, Monod M, Weber J, Harshman K, Pradervand S, Thomas J, et al. Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins. Eukaryot Cell. 2009;8:241-50.
37. Martinez-Rossi NM, Peres NTA, Rossi A. Antifungal resistance mechanisms in dermatophytes. Mycopathologia. 2008;166:369-83.
38. Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia. 2008;166:353-67.
39. Mukherjee PK, Leidich SD, Isham N, Leitner I, Ryder NS, Ghannoum MA. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother. 2003;47:82-6.
40. Fachin AL, Ferreira-Nozawa MS, Maccheroni W Jr, Martinez-Rossi NM. Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. J Med Microbiol. 2006;55:1093-9.
41. Cervelatti E P, Fachin AL, Ferreira-Nozawa MS, Martinez-Rossi NM. Molecular cloning and characterization of a novel ABC transporter gene in the human pathogen Trichophyton rubrum. Med Mycol. 2006;44:141-7.
42. Maranhão FCA, Paiao FG, Fachin AL, Martinez-Rossi NM. Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. J Med Microbiol. 2009;58:163-8.
43. Rocha EMF, Gardiner RE, Park S, Martinez-Rossi NM, Perlin DS. A Phe389Leu substitution in ErgA confers terbinafine resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2006;50:2533-6.
44. Paião FG, Segato F, Cursino-Santos JR, Peres NT, Martinez-Rossi NM. Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs. FEMS Microbiol Lett. 2007;271:180-6.
45. Segato F, Nozawa SR, Rossi A, Martinez-Rossi NM. Overexpression of genes coding for proline oxidase, riboflavin kinase, cytochrome c oxidase and an MFS transporter induced by acriflavin in Trichophyton rubrum. Med Mycol. 2008;46:135-9.
46. Yu L, Zhang W, Liu T, Wang X, Peng J, Li S, et al. Global gene expression of Trichophyton rubrum in response to PH11B, a novel fatty acid synthase inhibitor. J Appl Microbiol. 2007;103:2346-52.