Natalizumab treatment in paediatric multiple sclerosis: A case of induction, de-escalation and escalation

European Journal of Neurology

Volumn 17, Issue 11, 2010, Pages

  Putzki, Norman ^a,b   Stich, Oliver ^c   Gartzen, Kristina ^a   Kastrup, Oliver ^a   Tettenborn, Barbara ^b   Rauer, Sebastian ^c  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Disease modifying therapy; Interferon beta; Natalizumab; Paediatric multiple sclerosis

Indexed keywords

BETA1A INTERFERON; GADOLINIUM; NATALIZUMAB; OLIGOCLONAL BAND;

CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHILD; CHILDHOOD DISEASE; CONTRAST ENHANCEMENT; DISEASE ACTIVITY; DRUG PULSE THERAPY; DRUG TOLERABILITY; FEMALE; HUMAN; LETTER; MULTIPLE SCLEROSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PRIORITY JOURNAL; RELAPSE; REMISSION; SCHOOL CHILD; STEROID THERAPY; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIBODIES, MONOCLONAL; CHILD; DISABILITY EVALUATION; FEMALE; HUMANS; INTEGRIN ALPHA4; MULTIPLE SCLEROSIS; SEVERITY OF ILLNESS INDEX;

EID: 78650446732     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.03178.x     Document Type: Letter

References (9)

1. Pohl D, Rostasy K, Gärtner J, Hahnefeld V. Treatment of early onset multiple sclerosis with subcutaneous interferon beta 1a. Neurology 2005; 64: 888-890.
2. Banwell B, Reder AT, Krupp L, et al. Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis. Neurology 2006; 66: 472-476.
3. Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899-910.
4. Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 2007; 68: S7-S12.
5. Simone IL, Carrara D, Tortorella C, et al. Course and prognosis in early-onset MS. Neurology 2002; 59: 1922-1928.
6. Borriello G, Prosperini L, Lcuetti A, Pozzilli C. Natalizumab treatment in pediatric multiple sclerosis: a case report. Eur J Paediatr Neurol 2009; 13: 67-71.
7. Huppke P, Stark W, Zürcher C, Huppke B, Brück W, Gärtner J, et al. Natalizumab use in pediatric multiple sclerosis. Arch Neurol 2008; 65: 1655-1658.
8. Mikaeloff Y, Caridade G, Assi S, et al. Prognostic factors of early severity in a childhood multiple sclerosis cohort. Pediatrics 2006; 118: 1133-1139.
9. Pohl D, Waubant E, Banwell B, Chabas D, et al. Treatment of pediatric multiple sclerosis and variants. International Pediatric MS Study Group. Neurology 2007; 17: 68.