T2 lesion location really matters: A 10 year follow-up study in primary progressive multiple sclerosis

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 82, Issue 1, 2011, Pages 72-77

  Bodini, B ^a,b   Battaglini, M ^c   De Stefano, N ^c   Khaleeli, Z ^a   Barkhof, F ^d   Chard, D ^a   Filippi, M ^e   Montalban, X ^f   Polman, C ^d   Rovaris, M ^e,g   Rovira, A ^f   Samson, R ^a   Miller, D ^a   Thompson, A ^a   Ciccarelli, O ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN MAPPING; DISABILITY; DISEASE COURSE; FEMALE; FOLLOW UP; FRONTAL CORTEX; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; OCCIPITAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL TRACT; WALKING;

EID: 78650445004     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2009.201574     Document Type: Article

References (41)

1. Khaleeli Z, Ciccarelli O, Manfredonia F, et al. Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study. Ann.Neurol 2008;63:790-3. (Pubitemid 351945538)
2. Fisniku LK, Brex PA, Altmann DR, et al. Disability and T2 MRI lesions: A 20-year followup of patients with relapse onset of multiple sclerosis. Brain 2008;131:808-17.
3. Ingle GT, Stevenson VL, Miller DH, et al. Primary progressive multiple sclerosis: A 5-year clinical and MR study. Brain 2003;126:2528-36.
4. Sastre-Garriga J, Ingle GT, Rovaris M, et al. Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data. Neurology 2005;65:633-5.
5. Di Perri C, Battaglini M, Stromillo ML, et al. Voxel-based assessment of differences in damage and distribution of white matter lesions between patients with primary progressive and relapsingeremitting multiple sclerosis. Arch Neurol 2008;65:236-43.
6. Kragt JJ, Thompson AJ, Montalban X, et al. Responsiveness and predictive value of EDSS and MSFC in primary progressive MS. Neurology 2008;70:1084-91.
7. Nijeholt GJ, van Walderveen MA, Castelijns JA, et al. Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain 1998;121(Pt 4):687-97.
8. Rovaris M, Bozzali M, Santuccio G, et al. In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis. Brain 2001;124:2540-9.
9. Bieniek M, Altmann DR, Davies GR, et al. Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2006;77:1036-9.
10. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983;33:1444-52.
11. Lechner-Scott J, Kappos L, Hofman M, et al. Can the Expanded Disability Status Scale be assessed by telephone? Mult Scler 2003;9:154-9.
12. Stevenson VL, Miller DH, Rovaris M, et al. Primary and transitional progressive MS: A clinical and MRI cross-sectional study. Neurology 1999;52:839-45.
13. Plummer D. DispImage: A display and analysis tool for medical images. Rev Neuroradiol 1992;5:489-95.
14. Ginestroni A, Battaglini M, Della Nave R, et al. Early structural changes in individuals at risk of familial Alzheimer's disease: A volumetry and magnetization transfer MR imaging study. J Neurol 2009;256:925-32.
15. Vellinga MM, Geurts JJ, Rostrup E, et al. Clinical correlations of brain lesion distribution in multiple sclerosis. J Magn Reson Imaging 2009;29:768-73.
16. Karagulle Kendi AT, Lehericy S, Luciana M, et al. Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol 2008;29:501-5.
17. Mori S, Wakana S, Nagae-Poetscher LM, et al. MRI atlas of human white matter. Amsterdam, The Netherlands: Elsevier, 2005.
18. Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: A primer with examples. Hum Brain Mapp 2002;15:1-25.
19. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119(Pt 3):701-8.
20. Wilson M, Tench CR, Morgan PS, et al. Pyramidal tract mapping by diffusion tensor magnetic resonance imaging in multiple sclerosis: Improving correlations with disability. J Neurol Neurosurg Psychiatry 2003;74:203-7.
21. Reich DS, Zackowski KM, Gordon-Lipkin EM, et al. Corticospinal tract abnormalities are associated with weakness in multiple sclerosis. AJNR Am J Neuroradiol 2008;29:333-9.
22. Catani M, Howard RJ, Pajevic S, et al. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002;17:77-94.
23. Rizzolatti G, Matelli M. Two different streams form the dorsal visual system: Anatomy and functions. Exp Brain Res 2003;153:146-57.
24. He Y, Dagher A, Chen Z, et al. Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain 2009;132:3366-79.
25. Rocca MA, Colombo B, Falini A, et al. Cortical adaptation in patients with MS: A cross-sectional functional MRI study of disease phenotypes. Lancet Neurol 2005;4:618-26.
26. Reich DS, Smith SA, Zackowski KM, et al. Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis. Neuroimage 2007;38:271-9.
27. Schmahmann JD, Pandya DN. The complex history of the fronto-occipital fasciculus. J Hist Neurosci 2007;16:362-77.
28. Li DK, Held U, Petkau J, et al. MRI T2 lesion burden in multiple sclerosis: A plateauing relationship with clinical disability. Neurology 2006;66:1384-9.
29. Miki Y, Grossman RI, Udupa JK, et al. Relapsingeremitting multiple sclerosis: longitudinal analysis of MR imagesdlack of correlation between changes in T2 lesion volume and clinical findings. Radiology 1999;213:395-9.
30. Rudick RA, Lee JC, Simon J, et al. Significance of T2 lesions in multiple sclerosis: A 13-year longitudinal study. Ann Neurol 2006;60:236-42.
31. van Walderveen MA, Kamphorst W, Scheltens P, et al. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1998;50:1282-8.
32. Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 1996;47:1469-76.
33. O'Riordan JI, Gawne CM, Coles A, et al. T1 hypointense lesion load in secondary progressive multiple sclerosis: A comparison of pre versus post contrast loads and of manual versus semi automated threshold techniques for lesion segmentation. Mult Scler 1998;4:408-12.
34. Wakana S, Jiang H, Nagae-Poetscher LM, et al. Fiber tract-based atlas of human white matter anatomy. Radiology 2004;230:77-87.
35. Panitch H, Miller A, Paty D, et al. Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study. Neurology 2004;63:1788-95.
36. Montalban X, Sastre-Garriga J, Tintore M, et al. A single-centre, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis. Mult Scler 2009;15:1195-205.
37. Allen C, Jiang K, Malbecq W, et al. Time-to-event analysis, or who gets better sooner? An emerging concept in headache study methodology. Cephalalgia 1999;19:552-6.
38. Law CG, Brookmeyer R. Effects of mid-point imputation on the analysis of doubly censored data. Stat Med 1992;11:1569-78.
39. Cottrell DA, Kremenchutzky M, Rice GP, et al. The natural history of multiple sclerosis: A geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis. Brain 1999;122(Pt 4):625-39. (Pubitemid 29158771)
40. Kidd D, Barkhof F, McConnell R, et al. Cortical lesions in multiple sclerosis. Brain 1999;122(Pt 1):17-26.
41. Geurts JJ, Bo L, Pouwels PJ, et al. Cortical lesions in multiple sclerosis: Combined postmortem MR imaging and histopathology. AJNR Am J Neuroradiol 2005;26:572-7.