A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast

FEMS Yeast Research

Volumn 10, Issue 7, 2010, Pages 812-818

  Bink, Anna ^a   Govaert, Gilmer ^a   François, Isabelle E J A ^a   Pellens, Klaartje ^a   Meerpoel, Lieven ^b   Borgers, Marcel ^c,d   Van Minnebruggen, Geert ^c   Vroome, Valérie ^c   Cammue, Bruno P A ^a   Thevissen, Karin ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c Barrier Therapeutics NV   (Belgium)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Apoptosis; Caspase; Fungicidal; Lipid raft; Mitochondrial fission machinery; Piperazine 1 carboxamidine

Indexed keywords

4 [[3 (4 CHLOROBENZYL) 2 METHOXYQUINOLIN 6 YL]METHYL]PIPERAZINE 1 CARBOXIMIDAMIDE; CASPASE; FUNGICIDE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; APOPTOSIS; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; MITOCHONDRION; NONHUMAN; NUCLEAR ENERGY; SACCHAROMYCES CEREVISIAE; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIFUNGAL AGENTS; APOPTOSIS; GTP PHOSPHOHYDROLASES; MEMBRANE MICRODOMAINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PIPERAZINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 78650441381     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2010.00663.x     Document Type: Article

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