TNF: A tumor-suppressing factor or a tumor-promoting factor?

Future Oncology

Volumn 6, Issue 12, 2010, Pages 1833-1836

  Balkwill, Fran ^a   Joffroy, Christian ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Drosophila; inflammation; Ras; TNF

Indexed keywords

RAS PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ASSESSMENT; CYTOKINE PRODUCTION; DNA DAMAGE; DROSOPHILA MELANOGASTER; GENE MUTATION; INNATE IMMUNITY; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 78650432937     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.10.155     Document Type: Article

References (14)

1. Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M: Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev. Cell 18, 999-1011 (2010).
2. Vidal M, Cagan RL: Drosophila models for cancer research. Curr. Opin. Genet. Dev. 16, 10-16 (2006).
3. Guerra C, Schuhmacher AJ, Cañamero M et al.: Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11, 291-302 (2007).
4. Moore RJ, Owens DM, Stamp G et al.: Tumour necrosis factor-a deficient mice are resistant to skin carcinogenesis. Nat. Med. 5, 828-831 (1999).
5. Arnott CH, Scott KA, Moore RJ et al.: Tumour necrosis factor-a mediates tumour promotion via a PKCa-AP-1-dependent pathway. Oncogene 21, 4728-4738 (2002).
6. Scott KA, Arnott CH, Robinson SC et al.: TNF-a regulates epithelial expression of MMP-9 and integrin avb6 during tumour promotion. A role for TNF-a in keratinocyte migration? Oncogene 23, 6954-6966 (2004).
7. Balkwill F: Tumour necrosis factor and cancer and cancer: a timeline. Nat. Rev. Cancer 9, 361-371 (2009).
8. Harrison ML, Obermueller E, Maisey NR et al.: Tumor necrosis factor a as a new target for renal cell carcinoma: two sequential Phase II trials of infliximab at standard and high dose. J. Clin. Oncol. 25, 4542-4549 (2007).
9. Galbán S, Fan J, Martindale JL et al.: von Hippel-Lindau protein-mediated repression of tumor necrosis factor-a translation revealed through use of cDNA arrays. Mol. Cell Biol. 23, 2316-2328 (2003).
10. Mantovani A, Allavena P, Sica A, Balkwill F: Cancer-related inflammation. Nature 454, 436-444 (2008).
11. Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO: Loss of human scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. Oncogene 27, 5988-6001 (2008).
12. Fujiki H, Suganuma M, Kurusu M et al.: New TNF-a releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mut. Res. 523, 119-125 (2003).
13. Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies. JAMA 295, 2275-2285 (2006).
14. Askling J, Bongartz T: Malignancy and biologic therapy in rheumatoid arthritis. Curr. Opin. Rheumatol. 20, 334-339 (2008).