Impact of generic substitution decision support on electronic prescribing behavior

Journal of the American Medical Informatics Association

Volumn 17, Issue 6, 2010, Pages 681-688

  Stenner, Shane P ^a   Chen, Qingxia ^a   Johnson, Kevin B ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENERIC DRUG;

ARTICLE; DECISION SUPPORT SYSTEM; DRUG FORMULATION; ELECTRONIC PRESCRIBING; INTERVENTION STUDY; NURSE; OUTPATIENT; PHYSICIAN; RETROSPECTIVE STUDY; UNIVERSITY HOSPITAL;

DECISION SUPPORT SYSTEMS, CLINICAL; DRUG SUBSTITUTION; DRUGS, GENERIC; ELECTRONIC PRESCRIBING; HUMANS; MEDICAL ORDER ENTRY SYSTEMS; NURSE'S PRACTICE PATTERNS; PHYSICIAN'S PRACTICE PATTERNS; REGRESSION ANALYSIS; REMINDER SYSTEMS; RETROSPECTIVE STUDIES; TENNESSEE; USER-COMPUTER INTERFACE;

EID: 78650426678     PISSN: 10675027     EISSN: 1527974X     Source Type: Journal    
DOI: 10.1136/jamia.2009.002568     Document Type: Article

References (43)

1. IMS Health. IMS Health Reports U.S. Prescription Sales Grew 3.8 Percent in 2007, to $286.5 Billion. Press Release 2008 Mar 12.
2. Keehan S, Sisko A, Truffer C, et al. Health spending projections through 2017: the baby-boom generation is coming to Medicare. Health Aff (Millwood) 2008;27:145-55.
3. National Association of Chain Drug Stores. Table 151. Retail Prescription Drug Sales. NACDS Foundation Chain Pharmacy Industry Profile, 2007. http://www.census.gov/compendia/statab/tables/09s0151.xls (accessed 16 Jun 2009).
4. IMS Health. The United States is also the world's largest consumer of prescription drugs, accounting for almost half of global pharmaceutical sales in 2007. Global Pharmaceutical Sales by Region 2007, 2008.
5. Weisbart E. Taming pharmacy: driving out waste one consumer at a time. Express scripts, 2008. http://personnel.ky.gov/NR/rdonlyres/36B1DA8B-7F0B-4A48-BA1E-73D7BDC436B7/0/ExpressScriptsPresentation0508.pdf (accessed 16 Jun 2009).
6. Haas JS, Phillips KA, Gerstenberger EP, et al. Potential savings from substituting generic drugs for brand-name drugs: medical expenditure panel survey, 1997-2000. Ann Intern Med 2005;142:891-7.
7. Schoen C, Osborn R, Doty MM, et al. Toward higher-performance health systems: adults' health care experiences in seven countries, 2007. Health Aff (Millwood) 2007;26:w717-34.
8. Shrank WH, Hoang T, Ettner SL, et al. The implications of choice: prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions. Arch Intern Med 2006;166:332-7.
9. American Medical Association. Report 2 of the Council on Science and Public Health (A-07). 2007. http://www.ama-assn.org/ama/no-index/about-ama/17730.shtml (accessed 16 Jun 2009).
10. Pham HH, Alexander GC, O'Malley AS. Physician consideration of patients' out-ofpocket costs in making common clinical decisions. Arch Intern Med 2007;167:663-8.
11. Federman AD, Halm EA, Siu AL. Use of generic cardiovascular medications by elderly Medicare beneficiaries receiving generalist or cardiologist care. Med Care 2007;45:109-15.
12. Shrank WH, Stedman M, Ettner SL, et al. Patient, physician, pharmacy, and pharmacy benefit design factors related to generic medication use. J Gen Intern Med 2007;22:1298-304.
13. Kohl H, Shrank WH. Increasing generic drug use in Medicare Part D: the role of government. J Am Geriatr Soc 2007;55:1106-9.
14. Madden JM, Graves AJ, Zhang F, et al. Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D. JAMA 2008;299:1922-8.
15. Purvis L. Insight on the Issues: Strategies to Increase Generic Drug Utilization and Associated Savings, Vol 16. Washington DC: AARP Public Policy Institute, 2008.
16. Fischer MA, Vogeli C, Stedman M, et al. Effect of electronic prescribing with formulary decision support on medication use and cost. Arch Intern Med 2008;168:2433-9.
17. Medco. Growing confidence in generic drugs may help you reduce prescription drug costs. Medco Monitor 2005;1:1-2.
18. Waber RL, Shiv B, Carmon Z, et al. Commercial features of placebo and therapeutic efficacy. JAMA 2008;299:1016-17.
19. Shrank WH, Agnew-Blais J, Choudhry NK, et al. The variability and quality of medication container labels. Arch Intern Med [Research Support, Non-U.S. Gov't] 2007;167:1760-5.
20. Wolf MS, Davis TC, Shrank W, et al. To err is human: patient misinterpretations of prescription drug label instructions. Patient Educ Couns 2007;67:293-300.
21. Wolf MS, Davis TC, Tilson HH, et al. Misunderstanding of prescription drug warning labels among patients with low literacy. Am J Health-Syst Pharm 2006;63:1048-55.
22. Kimberlin CL, Winterstein AG. Expert and Consumer Evaluation of Consumer Medication Information-2008. Final Report to the U.S. Department of Health and Human Services and the Food and Drug Administration. http://www.fda.gov/AboutFDA/CentersOffices/CDER/ReportsBudgets/ucm163777.htm (accessed 28 Sep 2010).
23. Shrank WH, Avorn J. Educating patients about their medications: the potential and limitations of written drug information. Health Aff [Research Support, Non-U.S. Gov't] 2007;26:731-40.
24. Wolf MS, Davis TC, Shrank WH, et al. A critical review of FDA-approved Medication Guides. Patient Educ Couns 2006;62:316-22.
25. Barrett L. Physicians' Attitudes and Practices Regarding Generic Drugs. AARP Knowledge Management, Mar 2005. http://assets.aarp.org/rgcenter/health/phys_generic.pdf (accessed 16 Jun 2009).
26. Raffaele M. States combat drug reps to cut costs. Washington Post 2008 Mar 2.
27. Bielby J, Silagy E. Trials of providing costing information to general practitioners: a systematic review. Med J Aust 1997;167:89-92.
28. Wadland WC, Farquhar L, Priester F, et al. Increasing generic prescribing: a resident educational intervention. Fam Med 2005;37:259-64.
29. Ross SM, Papshev D, Murphy EL, et al. Effects of electronic prescribing on formulary compliance and generic drug utilization in the ambulatory care setting: a retrospective analysis of administrative claims data. J Manag Care Pharm 2005;11:410-15.
30. Lyman JA, Conaway M, Lowenhar S. Formulary access using a PDA-based drug reference tool: does it affect prescribing behavior? AMIA Annu Symp Proc 2008:1034.
31. U.S. House of Representatives Ways and Means Committee. Congress 111, Session 1. A Bill to Provide for a Portion of the Economic Recovery Package Relating to Revenue Measures, Unemployment, and Health, 2009:138-328. http://waysandmeans.house.gov/media/pdf/110/sbill.pdf (accessed 16 Jun 2009).
32. Langston. Consider e-Prescribing as One Step in Climb to Health IT. American Medical News 2008 Apr 7.
33. Johnson KB, Feldman MJ. Medical informatics and pediatrics. Decision-support systems. Arch Pediatr Adolesc Med 1995;149:1371-80.
34. Johnson KB, Fitzhenry F. Case report: activity diagrams for integrating electronic prescribing tools into clinical workflow. J Am Med Inform Assoc 2006;13:391-5.
35. Rodriguez MJ, Diaz S, Vera-Llonch M, et al. Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia. Curr Med Res Opin 2007;23:2585-96.
36. Duh MS, Andermann F, Paradis PE, et al. The economic consequences of generic substitution for antiepileptic drugs in a public payer setting: the case of lamotrigine. Dis Manag 2007;10:216-25.
37. Heaney DC, Sander JW. Antiepileptic drugs: generic versus branded treatments. Lancet Neurol 2007;6:465-8.
38. Kim CS, Kristopaitis RJ, Stone E, et al. Physician education and report cards: do they make the grade? Results from a randomized controlled trial. Am J Med 1999;107:556-60.
39. O'Brien M A, Rogers S, Jamtvedt G, et al. Educational outreach visits: effects on professional practice and health care outcomes. Cochrane Database Syst Rev 2007;4:CD000409.
40. McDonald CJ. Protocol-based computer reminders, the quality of care and the nonperfectability of man. N Engl J Med 1976;295:1351-5.
41. Miller RA, Waitman LR, Chen S, et al. The anatomy of decision support during inpatient care provider order entry (CPOE): empirical observations from a decade of CPOE experience at Vanderbilt. J Biomed Inform 2005;38:469-85.
42. International Association of Generic & Innovative Drug Manufacturers. Drugs off-patent reports 2000, 2001. http://www.locumusa.com/pdf/members/100m+00.pdf (accessed 16 Jun 2009).
43. Express Scripts I. Express Scripts, Inc. Geographic variation in generic fill rate. http://www.express-scripts.com/research/studies/healthservicesresearch/pharmacoepidemiology/docs/regionalgenericvariation.pdf (accessed 1 Jul 2010).