Impact of older age on presentation, management and outcome of breast cancer in the multi-ethnic Asian population of Singapore

Journal of Geriatric Oncology

Volumn 2, Issue 1, 2011, Pages 50-57

  Saxena, Nakul ^a   Hartman, Mikael ^a,b   Hussain, Zakir ^a   Pathy, Nirmala Bhoo ^c,d   Iau, Philip ^b   Lee, Soo Chin ^a   Lee, Khai Mun ^a   Lim, Siew Eng ^a   Wong, John E L ^a   Verkooijen, Helena M ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Breast cancer; Diagnosis; Elderly patients; Relative survival; Treatment

Indexed keywords

ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR;

ADULT; ADVANCED CANCER; AGE DISTRIBUTION; AGED; AGING; ARTICLE; AXILLARY LYMPH NODE; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; ELDERLY CARE; ETHNICITY; FEMALE; HUMAN; INTRADUCTAL CARCINOMA; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; PARTIAL MASTECTOMY; POPULATION RESEARCH; SINGAPORE; SURVIVAL RATE; SURVIVAL TIME; TREATMENT RESPONSE;

EID: 78650417398     PISSN: 18794068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgo.2010.08.002     Document Type: Article

References (34)

1. Benson J.R., Jatoi I., Keisch M., Esteva F.J., Makris A., Jordan V.C. Early breast cancer. Lancet 2009, 373(9673):1463-1479.
2. Barnett G.C., Shah M., Redman K., Easton D.F., Ponder B.A., Pharoah P.D. Risk factors for the incidence of breast cancer: do they affect survival from the disease?. J Clin Oncol 2008, 26(20):3310-3316.
3. Veronesi U., Boyle P., Goldhirsch A., Orecchia R., Viale G. Breast cancer. Lancet 2005, 365(9472):1727-1741.
4. Bernardi D., Errante D., Gallligioni E., Crivellari D., Bianco A., Salvagno L., et al. Treatment of breast cancer in older women. Acta Oncol 2008, 47(2):187-198.
5. Diab S.G., Elledge R.M., Clark G.M. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 2000, 92(7):550-556.
6. Kamangar F., Dores G.M., Anderson W.F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006, 24(14):2137-2150.
7. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55(2):74-108.
8. Kwong A., Cheung P., Chan S., Lau S. Breast cancer in Chinese women younger than age 40: are they different from their older counterparts?. World J Surg 2008, 32(12):2554-2561.
9. Sim X., Ali R.A., Wedren S., Goh D.L., Tan C.S., Reilly M., et al. Ethnic differences in the time trend of female breast cancer incidence: Singapore, 1968-2002. BMC Cancer 2006, 6:261.
10. Lim S.E., Back M., Quek E., Iau P., Putti T., Wong J.E. Clinical observations from a breast cancer registry in Asian women. World J Surg 2007, 31(7):1387-1392.
11. Jara-Lazaro A.R., Thilagaratnam S., Tan P.H. Breast cancer in Singapore: some perspectives. Breast Cancer 2009, 17(1):23-28.
12. Newcomb P.A., Carbone P.P. Cancer treatment and age: patient perspectives. J Natl Cancer Inst 1993, 85(19):1580-1584.
13. Hutchins L.F., Unger J.M., Crowley J.J., Coltman C.A., Albain K.S. Underrepresentation of patients 65years of age or older in cancer-treatment trials. N Engl J Med 1999, 341(27):2061-2067.
14. Schonberg M.A., Marcantonio E.R., Li D., Silliman R.A., Ngo L., McCarthy E.P. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. J Clin Oncol 2010, 28(12):2038-2045.
15. Bouchardy C., Rapiti E., Fioretta G., Laissue P., Neyroud-Caspar I., Schafer P., et al. Undertreatment strongly decreases prognosis of breast cancer in elderly women. J Clin Oncol 2003, 21(19):3580-3587.
16. Mandelblatt J.S., Hadley J., Kerner J.F., Schulman K.A., Gold K., Dunmore-Griffith J., et al. Patterns of breast carcinoma treatment in older women: patient preference and clinical and physical influences. Cancer 2000, 89(3):561-573.
17. Singletary S.E., Connolly J.L. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin 2006, 56(1):37-47. quiz 50-1.
18. Ederer F., Axtell L.M., Cutler S.J. The relative survival rate: a statistical methodology. Natl Cancer Inst Monogr 1961 Sep, 6:101-121.
19. Dickman P.W., Adami H.O. Interpreting trends in cancer patient survival. J Intern Med 2006 Aug, 260(2):103-117.
20. Daidone M.G., Coradini D., Martelli G., Veneroni S. Primary breast cancer in elderly women: biological profile and relation with clinical outcome. Crit Rev Oncol Hematol 2003, 45(3):313-325.
21. Molino A., Giovannini M., Auriemma A., Fiorio E., Mercanti A., Mandara M., et al. Pathological, biological and clinical characteristics, and surgical management, of elderly women with breast cancer. Crit Rev Oncol Hematol 2006, 59(3):226-233.
22. Ma C.D., Zhou Q., Nie X.Q., Liu G.Y., Di G.H., Wu J., et al. Breast cancer in Chinese elderly women: pathological and clinical characteristics and factors influencing treatment patterns. Crit Rev Oncol Hematol 2009, 71(3):258-265.
23. Ong CS, Ooi G, Tan XQ, Lee J, Koh GC, Verkooijen HM. Prevalence of limited cancer knowledge in Singaporeans, its determinants and association with cancer screening. Prev Med; 50(5-6):304-5.
24. Wee S.B. The case for breast cancer screening in Singapore. Singapore Med J 2002, 43(5):221-223.
25. Hebert-Croteau N., Brisson J., Latreille J., Blanchette C., Deschenes L. Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women. Cancer 1999, 85(5):1104-1113.
26. Du X., Goodwin J.S. Patterns of use of chemotherapy for breast cancer in older women: findings from Medicare claims data. J Clin Oncol 2001, 19(5):1455-1461.
27. Townsley C.A., Selby R., Siu L.L. Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J Clin Oncol 2005, 23(13):3112-3124.
28. Enger S.M., Thwin S.S., Buist D.S., Field T., Frost F., Geiger A.M., et al. Breast cancer treatment of older women in integrated health care settings. J Clin Oncol 2006, 24(27):4377-4383.
29. Audisio R.A., Bozzetti F., Gennari R., Jaklitsch M.T., Koperna T., Longo W.E., et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force. Eur J Cancer 2004, 40(7):926-938.
30. Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 1998, 352(9132):930-942. Early Breast Cancer Trialists' Collaborative Group.
31. Maggard M.A., O'Connell J.B., Lane K.E., Liu J.H., Etzioni D.A., Ko C.Y. Do young breast cancer patients have worse outcomes?. J Surg Res 2003, 113(1):109-113.
32. Ugnat A.M., Xie L., Morriss J., Semenciw R., Mao Y. Survival of women with breast cancer in Ottawa, Canada: variation with age, stage, histology, grade and treatment. Br J Cancer 2004, 90(6):1138-1143.
33. Vinh-Hung V., Verschraegen C. Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst 2004, 96(2):115-121.
34. Seow W.K., Chia K.S., Lee H.P., Shanmugaratnam K. Trends In Cancer Incidence In Singapore 1968-2002 2004, Singapore Cancer Registry.