Evaluation of the protective effects of quercetin, rutin, resveratrol, naringenin and trolox against idarubicin-induced dna damage

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 13, Issue 2, 2010, Pages 231-241

  Çelik, Haydar ^a,b   Arinç, Emel ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

^b ERCIYES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

AURANTIIN; CYTOCHROME P450 REDUCTASE; IDARUBICIN; MITOMYCIN C; PLASMID DNA; QUERCETIN; RESVERATROL; RUTOSIDE; TROLOX C;

ANIMAL CELL; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; IN VITRO STUDY; INHIBITION KINETICS; LIVER MICROSOME; NONHUMAN; PLASMID; PROTECTION; RABBIT; SINGLE STRANDED DNA BREAK;

EID: 78650413625     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3s01g     Document Type: Article

References (44)

1. Havsteen, B.H., The biochemistry and medical significance of the flavonoids. Pharmacol Ther, 96:67-202, 2002.
2. Ross, J.A., Kasum, C.M., Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr, 22:19-34, 2002.
3. Surh, Y.J., Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer, 3:768-780, 2003.
4. Boudet, A.M., Evolution and current status of research in phenolic compounds. Phytochemistry, 68:2722-2735, 2007.
5. Fang, Y.Z., Yang, S., Wu, G., Free radicals, antioxidants, and nutrition. Nutrition, 18:872-879, 2002.
6. Hollman, P.C., Katan, M.B., Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol, 37:937-942, 1999.
7. Rice-Evans, C.A., Miller, N.J., Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans, 24:790-795, 1996.
8. Nijveldt, R.J., van Nood, E., van Hoorn, D.E., Boelens, P.G., van Norren, K., van Leeuwen, P.A., Flavonoids: a review of probablemechanisms of action and potential applications. Am J Clin Nutr, 74:418-425, 2001.
9. Lotito, S.B., Frei, B., Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radic Biol Med, 41:1727-1746, 2006.
10. Lamson, D.W., Brignall, M.S., Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev, 4:304-329, 1999.
11. Block, K.I., Antioxidants and cancer therapy: furthering the debate. Integr Cancer Ther, 3:342-348, 2004.
12. Prasad, K.N., Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr Cancer Ther, 3:310-322, 2004.
13. Weijl, N.I., Cleton, F.J., Osanto, S., Free radicals and antioxidants in chemotherapyinduced toxicity. Cancer Treat Rev, 23:209-240, 1997.
14. Borchmann, P., Hübel, K., Schnell, R., Engert, A., Idarubicin: a brief overview on pharmacology and clinical use. Int J Clin Pharmacol Ther, 35:80-83, 1997.
15. Gewirtz, D.A., A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol, 57:727-741, 1999.
16. Çelik, H., Arinç, E., Comparison of the in vitro DNA-damaging potential of the two anticancer drugs idarubicin and mitomycin C in the presence of NADPH-cytochrome P450 reductase. Drug Metab Rev, 38 (Suppl. 1):185-186, 2006.
17. Çelik, H., Arinç, E., Mechanisms and involvements of NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase in mitomycin C and idarubicin promoted DNA damage and "ROS" formation: a study with rabbit liver microsomes and purified enzymes. Drug Metab Rev, 38 (Suppl. 2):91-92, 2006.
18. Çelik, H., Arinç, E., Bioreduction of idarubicin and formation of ROS responsible for DNA cleavage by NADPH-cytochrome P450 reductase and its potential role in the antitumor effect. J Pharm Pharm Sci, 11:68-82, 2008.
19. Adali, O., Arinç, E., Electrophoretic, spectral, catalytic and immunochemical properties of highly purified cytochrome P-450 from sheep lung. Int J Biochem, 22:1433-1444, 1990.
20. Arinç, E., Sen, A., Characterization of cytochrome P450-dependent mixed-function oxidase system of gilthead seabream (Sparus aurata; sparidae) liver. Comp BiochemPhysiol B Biochem Mol Biol, 104:133-139, 1993.
21. Işcan, M.Y., Arinç, E., Kinetic and structural properties of biocatalytically active sheep lung microsomal NADPH-cytochrome c reductase. Int J Biochem, 18:731-741, 1986.
22. Işcan, M.Y., Arinç, E., Comparison of highly purified sheep liver and lung NADPHcytochrome P-450 reductases by the analysis of kinetic and catalytic properties. Int J Biochem, 20:1189-1196, 1988.
23. Sen, A., Arinç, E., Purification and characterization of cytochrome P450 reductase from liver microsomes of feral leaping mullet (Liza saliens). J Biochem Mol Toxicol, 12:103-113, 1998.
24. Arinç, E., Çelik, H., Biochemical characteristics of purified beef liver NADPHcytochrome P450 reductase. J Biochem Mol Toxicol, 16:286-297, 2002.
25. Bozcaarmutlu, A., Arinç, E., Effect of mercury, cadmium, nickel, chromium and zinc on kinetic properties of NADPHcytochrome P450 reductase purified from leaping mullet (Liza saliens). Toxicol In Vitro, 21:408-416, 2007.
26. Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227:680-685, 1970.
27. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent. J Biol Chem, 193:265-275, 1951.
28. Fisher, G.R., Gutierrez, P.L., Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DTdiaphorase) and NADPH cytochrome c reductase. Free Radic Biol Med, 11:597-607, 1991.
29. Shen, T., Hollenberg, P.F., The mechanism of stimulation of NADPH oxidation during the mechanism-based inactivation of cytochrome P450 2B1 by N-methylcarbazole: redox cycling and DNA scission. Chem Res Toxicol, 7:231-238, 1994.
30. 2 on plasmid DNA. Mutat Res, 466:1-7, 2000.
31. Seow, H.A., Penketh, P.G., Baumann, R.P., Sartorelli, A.C., Bioactivation and resistance to mitomycin C. Methods Enzymol, 382:221-233, 2004.
32. Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., Gianni, L., Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev, 56:185-229, 2004.
33. Hertog, M.G., Hollman, P.C., Katan, M.B., Kromhout, D., Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer, 20:21-29, 1993.
34. Noroozi, M., Angerson, W.J., Lean, M.E., Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Am J Clin Nutr, 67:1210-1218, 1998.
35. Kim, D.O., Lee, C.Y., Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. Crit Rev Food Sci Nutr, 44:253-273, 2004.
36. MacDonald, I.A., Mader, J.A., Bussard, R.G., The role of rutin and quercitrin in stimulating flavonol glycosidase activity by cultured cellfree microbial preparations of human feces and saliva. Mutat Res, 122:95-102, 1983.
37. Bokkenheuser, V.D., Shackleton, C.H., Winter, J., Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans. Biochem J, 248:953-956, 1987.
38. Sun, A.Y., Simonyi, A., Sun, G.Y., The French Paradox and beyond: neuroprotective effects of polyphenols. Free Radic Biol Med, 32:314-318, 2002.
39. Pari, L., Gnanasoundari, M., Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol, 98:456-461, 2006.
40. Rice-Evans, C., Flavonoid antioxidants. Curr Med Chem, 8:797-807, 2001.
41. Melidou, M., Riganakos, K., Galaris, D., Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. Free Radic Biol Med, 39:1591-1600, 2005.
42. Wu, T.W., Hashimoto, N., Wu, J., Carey, D., Li, R.K., Mickle, D.A., Weisel, R.D., The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol, 68:1189-1194, 1990.
43. Kumar, S.S., Chaubey, R.C., Devasagayam, T.P., Priyadarsini, K.I., Chauhan, P.S., Inhibition of radiation-induced DNA damage in plasmid pBR322 by chlorophyllin and possible mechanism(s) of action. Mutat Res, 425:71-79, 1999.
44. Anderson, D., Yu, T.W., Phillips, B.J., Schmezer, P., The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay. Mutat Res, 307:261-271, 1994.