Does gamma-hydroxybutyrate (GHB) have a role in the treatment of alcoholism?

Alcohol and Alcoholism

Volumn 46, Issue 1, 2011, Pages 1-2

  Sewell, R Andrew ^a   Petrakis, Ismene L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBUTYRIC ACID; ACAMPROSATE; DISULFIRAM; NALTREXONE;

ALCOHOL WITHDRAWAL; ALCOHOLICS ANONYMOUS; ALCOHOLISM; DRUG MECHANISM; EDITORIAL; GABAERGIC SYSTEM; HUMAN; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

ALCOHOLISM; GABA AGENTS; HUMANS; RECURRENCE; SODIUM OXYBATE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 78650413341     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agq086     Document Type: Editorial

References (7)

1. ®): differences in characteristics and misuse. Drug Alcohol Depend 104:1-10.
2. Cash CD, Gobaille S, Kemmel V et al. (1999) Gamma-hydroxybutyrate receptor function studied by the modulation of nitric oxide synthase activity in rat frontal cortex punches. Biochem Pharmacol 58:1815-9.
3. Fuller DE, Hornfeldt CS, Kelloway JS et al. (2004) The Xyrem risk management program. Drug Saf 27:293-306.
4. Leone MA, Vigna-Taglianti F, Avanzi G et al. (2010) Gammahydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses. Cochrane Database Syst Rev 2:CD006266.
5. Rychtarik RG, Connors GJ, Dermen KH et al. (2000) Alcoholics Anonymous and the use of medications to prevent relapse: an anonymous survey of member attitudes. J Stud Alcohol 61:134-8.
6. Wang YG, Swick TJ, Carter LP et al. (2009) Safety overview of postmarketing and clinical experience of sodium oxybate (Xyrem): abuse, misuse, dependence, and diversion. J Clin Sleep Med 5:365-71.
7. Weiss C, Colyer C. (2010) Roofies, mickies and cautionary tales: examining the persistence of the "date-rape drug" crime narrative. Deviant Behav 31:348-79.