Cartilage intermediate layer protein gene is associated with lumbar disc degeneration in male, but not female, collegiate athletes

American Journal of Sports Medicine

Volumn 38, Issue 12, 2010, Pages 2552-2557

  Min, Seok Ki ^a   Nakazato, Koichi ^a   Yamamoto, Yosuke ^a   Gushiken, Koji ^a   Fujimoto, Hideo ^a   Fujishiro, Hitone ^a,b   Kobayakawa, Yuri ^a   Hiranuma, Kenji ^a  

^a NIPPON SPORT SCIENCE UNIVERSITY   (Japan)

^b TEIKYO HEISEI UNIVERSITY   (Japan)

Author keywords

CILP gene; disc degeneration; gender; sports

Indexed keywords

CILP PROTEIN, HUMAN; INORGANIC PYROPHOSPHATASE; SCLEROPROTEIN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BODY MASS; CHONDROPATHY; CONFIDENCE INTERVAL; CROSS-SECTIONAL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; INTERVERTEBRAL DISK DEGENERATION; JAPAN; LUMBAR VERTEBRA; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; RISK; RISK FACTOR; SEX DIFFERENCE; SPORT INJURY; STATISTICAL MODEL;

ANALYSIS OF VARIANCE; ATHLETIC INJURIES; BODY MASS INDEX; CARTILAGE DISEASES; CONFIDENCE INTERVALS; CROSS-SECTIONAL STUDIES; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENOTYPE; HUMANS; INTERVERTEBRAL DISK DEGENERATION; JAPAN; LOGISTIC MODELS; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; ODDS RATIO; POLYMORPHISM, GENETIC; PYROPHOSPHATASES; RISK FACTORS; SEX FACTORS; YOUNG ADULT;

EID: 78650411729     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546510376714     Document Type: Article

References (19)

1. Bartolozzi C., Caramella D., Zampa V., Dal Pozzo G., Tinacci E., Balducci F. The incidence of disk changes in volleyball players: the magnetic resonance findings [in Italian]. Radiol Med. 1991 ; 82: 757-760.
2. Boyer KA, Beaupre GS, Andriacchi TP Gender differences exist in the hip joint moments of healthy older walkers. J Biomech. 2008 ; 41: 3360-3365.
3. Hangai M., Kaneoka K., Hinotsu S., et al. Lumbar intervertebral disk degeneration in athletes. Am J Sports Med. 2009 ; 37: 149-155.
4. Iwai K., Nakazato K., Irie K., Fujimoto H., Nakajima H. Trunk muscle strength and disability level of low back pain in collegiate wrestlers. Med Sci Sports Exerc. 2004 ; 36: 1296-1300.
5. Kaneoka K., Shimizu K., Hangai M., et al. Lumbar intervertebral disk degeneration in elite competitive swimmers: a case control study. Am J Sports Med. 2007 ; 35: 1341-1345.
6. Miller JA, Schmatz C., Schultz AB Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine. 1988 ; 13: 173-178.
7. Min SK, Nakazato K., Okada T., Ochi E., Hiranuma K. The cartilage intermediate layer protein gene is associated with lumbar disc degeneration in collegiate judokas. Int J Sports Med. 2009 ; 30: 691-694.
8. Ochsmann E., Rüger H., Kraus T., Drexler H., Letzel S., Münster E. Gender-specific risk factors for acute low back pain: starting points for target-group-specific prevention [in German]. Schmerz. 2009 ; 23: 377-384.
9. Okada T., Nakazato K., Iwai K., Tanabe M., Irie K., Nakajima H. Body mass, nonspecific low back pain, and anatomical changes in the lumbar spine in judo athletes. J Orthop Sports Phys Ther. 2007 ; 37: 688-693.
10. Ong A., Anderson J., Roche J. A pilot study of the prevalence of lumbar disc degeneration in elite athletes with lower back pain at the Sydney 2000 Olympic Games. Br J Sports Med. 2003 ; 37: 263-266.
11. Pfirrmann CW, Metzdorf A., Zanetti M., Hodler J., Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001 ; 26: 1873-1878.
12. Riihimäki H., Wickström G., Hänninen K., Mattsson T., Waris P., Zitting A. Radiographically detectable lumbar degenerative changes as risk indicators of back pain: a cross-sectional epidemiologic study of concrete reinforcement workers and house painters. Scand J Work Environ Health. 1989 ; 15: 280-285.
13. Seki S., Kawaguchi Y., Chiba K., et al. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet. 2005 ; 37: 607-612.
14. Swärd L., Hellström M., Jacobsson B., Nyman R., Peterson L. Disc degeneration and associated abnormalities of the spine in elite gymnasts: a magnetic resonance imaging study. (Phila Pa 1976) Spine. 1991 ; 16: 437-443.
15. Takatalo J., Karppinen J., Niinimäki J., et al. Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine (Phila P a 1976). 2009 ; 34: 1716-1721.
16. Valdes AM, Van Oene M., Hart DJ, et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum. 2006 ; 54: 533-539.
17. Videman T., Nurminen M., Troup JD 1990 Volvo Award in clinical sciences: lumbar spinal pathology in cadaveric material in relation to history of back pain, occupation, and physical loading. Spine (Phila Pa 1976). 1990; 15: 728-740.
18. Videman T., Sarna S., Battié MC, et al. The long-term effects of physical loading and exercise lifestyles on back-related symptoms, disability, and spinal pathology among men. Spine. 1995 ; 20: 699-709.
19. Virtanen IM, Song YQ, Cheung KM, et al. Phenotypic and population differences in the association between CILP and lumbar disc disease. J Med Genet. 2007 ; 44: 285-288.