HPLC analysis of mesembrine-type alkaloids in Sceletium plant material used as an african traditional medicine

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 13, Issue 4, 2010, Pages 558-570

  Patnala, Srinivas ^a   Kanfer, Isadore ^a  

^a RHODES UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; DELTA7 MESEMBRENONE; EPIMESEMBRANOL; MESEMBRANOL; MESEMBRENONE; MESEMBRINE; UNCLASSIFIED DRUG;

ACCURACY; AFRICAN MEDICINE; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; NONHUMAN; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SCELETIUM;

EID: 78650356303     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3dk5f     Document Type: Article

References (10)

1. M.A. Strege. High-performance liquid chromatographic-electrospray ionization mass spectrometric analyses for the integration of natural products with modern high-throughput screening. J Chromatogr B, 725:67-78, 1999.
2. H.R. Keller, D.L. Massart, Y.Z Liang, O.M Kvalheim. A Comparison of heuristic evolving latent projections and evolving factor analysis methods for peak purity control in liquid chromatography with photodiode array detection. Anal Chim Acta. 267:63-71, 1992.
3. E.P Springfield, P.K.F Eagles, G. Scott. Quality assessment of South African herbal medicines by means of HPLC fingerprinting. J Ethnopharmacol 101:75-83, 2005.
4. WHO, Geneva. General guidelines for methodologies on research and evaluation of traditional medicine. WHO/EDM/TRM/2000.1: 1-74, 2006. [cited 2006 November 18] http://apps.who.int/medicinedocs/pdf/h2977e/h2977e.pdf
5. FDA, CDER. Guidance for Industry. Botanical drug products. June 2004. Available from: http://www.fda.gov/cder/guidance/4592fnl.pdf [cited 2006November 18]
6. European Medicines Agency. Concept Paper on CTD for Traditional Herbal Medicinal Products. EMEA/HMPC/261344/2005, 2006 March 9 [cited 2006 November 02]. Available from: http://www.emea.europa.eu/pdfs/human/hmpc/26134405en.pdf
7. Medicines and Healthcare products Regulatory Agency. Traditional Herbal Medicinal Products. Registration Dossier Requirements November 2004. [cited 2006 November 17] Available from: http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&nodeId=593
8. M.T. Smith, C.R. Field, N.R. Crouch, M. Hirst. The distribution of mesembrine alkaloids in selected TAXA of the mesembryanthemaceae and their modification in the Sceletium derived 'Kougoed' Pharmaceut Biol 36(3) (1998) 173-9.
9. N.P Gericke, B-E Van Wyk. US Patent Application number 09/194,836. Patent no US 6,288,104B1.
10. Scott G. and Springfield EP. Sceletium tortuosum herba. Pharmaceutical monographs for 60 South African plant species used as traditional medicines. South African National Biodiversity Institute. [cited 2006 November 26] Available from: http://www.plantzafrica.com/medmonographs/scelettort.pdf.