Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis

European Journal of Immunology

Volumn 41, Issue 1, 2011, Pages 67-75

  Sakai, Kazuki ^a,b   Kawata, Eri ^a   Ashihara, Eishi ^a,b   Nakagawa, Yoko ^a   Yamauchi, Akira ^c   Yao, Hisayuki ^a   Nagao, Rina ^a   Tanaka, Ruriko ^a   Yokota, Asumi ^a   Takeuchi, Miki ^a   Hirai, Hideyo ^a   Kimura, Shinya ^d   Hirashima, Mitsuomi ^c   Yoshimura, Norio ^b   Maekawa, Taira ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

^d SAGA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Galectin 9; GVH disease

Indexed keywords

ECALECTIN;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; FEMALE; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ACUTE DISEASE; ANIMALS; APOPTOSIS; CALCIUM CHANNELS; DISEASE MODELS, ANIMAL; FEMALE; GALECTINS; GRAFT VS HOST DISEASE; HUMANS; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 78650349323     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939931     Document Type: Article

References (34)

1. Barondes, S. H., Castronovo, V., Cooper, D. N., Cummings, R. D., Drickamer, K., Feizi, T., Gitt, M. A. et al., Galectins: a family of animal beta-galactoside-binding lectins. Cell 1994. 76: 597-598.
2. Cooper, D. N. and Barondes, S. H., God must love galectins; he made so many of them. Glycobiology 1999. 9: 979-984.
3. Chabot, S., Kashio, Y., Seki, M., Shirato, Y., Nakamura, K., Nishi, N., Nakamura, T. et al., Regulation of galectin-9 expression and release in Jurkat T cell line cells. Glycobiology 2002. 12: 111-118.
4. Matsumoto, R., Matsumoto, H., Seki, M., Hata, M., Asano, Y., Kanegasaki, S., Stevens, R. L. and Hirashima, M., Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J. Biol. Chem. 1998. 273: 16976-16984.
5. Kashio, Y., Nakamura, K., Abedin, M. J., Seki, M., Nishi, N., Yoshida, N., Nakamura, T. and Hirashima, M., Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J. Immunol. 2003. 170: 3631-3636.
6. Hirashima, M., Kashio, Y., Nishi, N., Yamauchi, A., Imaizumi, T. A., Kageshita, T., Saita, N. and Nakamura, T., Galectin-9 in physiological and pathological conditions. Glycoconj. J. 2004. 19: 593-600.
7. Irie, A., Yamauchi, A., Kontani, K., Kihara, M., Liu, D., Shirato, Y., Seki, M. et al., Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. Clin. Cancer Res. 2005. 11: 2962-2968.
8. Kobayashi, T., Kuroda, J., Ashihara, E., Oomizu, S., Terui, Y., Taniyama, A., Adachi, S. et al., Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways. Leukemia 2010. 24: 843-850.
9. Zhu, C., Anderson, A. C., Schubart, A., Xiong, H., Imitola, J., Khoury, S. J., Zheng, X. X. et al., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 2005. 6: 1245-1252.
10. Seki, M., Oomizu, S., Sakata, K. M., Sakata, A., Arikawa, T., Watanabe, K., Ito, K. et al., Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 2008. 127: 78-88.
11. Wang, F., He, W., Zhou, H., Yuan, J., Wu, K., Xu, L. and Chen, Z. K., The Tim-3 ligand galectin-9 negatively regulates CD8+alloreactive T cell and prolongs survival of skin graft. Cell Immunol. 2007. 250: 68-74.
12. Hill, G. R., Crawford, J. M., Cooke, K. R., Brinson, Y. S., Pan, L. and Ferrara, J. L., Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 1997. 90: 3204-3213.
13. Hill, G. R., Cooke, K. R., Teshima, T., Crawford, J. M., Keith, J. C., Jr., Brinson, Y. S., Bungard, D. and Ferrara, J. L., Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Clin. Invest. 1998. 102: 115-123.
14. Hill, G. R. and Ferrara, J. L., The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 2000. 95: 2754-2759.
15. Dai, S. Y., Nakagawa, R., Itoh, A., Murakami, H., Kashio, Y., Abe, H., Katoh, S. et al., Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 2005. 175: 2974-2981.
16. Anderson, A. C., Anderson, D. E., Bregoli, L., Hastings, W. D., Kassam, N., Lei, C., Chandwaskar, R. et al., Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 2007. 318: 1141-1143.
17. Albert, M. H., Liu, Y., Anasetti, C. and Yu, X. Z., Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur. J. Immunol. 2005. 35: 2598-2607.
18. Cohen, J. L. and Boyer, O., The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease. Curr. Opin. Immunol. 2006. 18: 580-585.
19. Nguyen, V. H., Zeiser, R., Dasilva, D. L., Chang, D. S., Beilhack, A., Contag, C. H. and Negrin, R. S., In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 2007. 109: 2649-2656.
20. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M. and Weaver, C. T., Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005. 6: 1123-1132.
21. Rohn, T. A., Jennings, G. T., Hernandez, M., Grest, P., Beck, M., Zou, Y., Kopf, M. and Bachmann, M. F., Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 2006. 36: 2857-2867.
22. Hirota, K., Hashimoto, M., Yoshitomi, H., Tanaka, S., Nomura, T., Yamaguchi, T., Iwakura, Y. et al., T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+Th cells that cause autoimmune arthritis. J. Exp. Med. 2007. 204: 41-47.
23. Yi, T., Chen, Y., Wang, L., Du, G., Huang, D., Zhao, D., Johnston, H. et al., Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 2009. 114: 3101-3112.
24. Carlson, M. J., West, M. L., Coghill, J. M., Panoskaltsis-Mortari, A., Blazar, B. R. and Serody, J. S., In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 2009. 113: 1365-1374.
25. Kappel, L. W., Goldberg, G. L., King, C. G., Suh, D. Y., Smith, O. M., Ligh, C., Holland, A. M. et al., IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 2009. 113: 945-952.
26. Chen, Y., Langrish, C. L., McKenzie, B., Joyce-Shaikh, B., Stumhofer, J. S., McClanahan, T., Blumenschein, W. et al., Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 2006. 116: 1317-1326.
27. Nakae, S., Iwakura, Y., Suto, H. and Galli, S. J., Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 2007. 81: 1258-1268.
28. Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235-238.
29. He, W., Fang, Z., Wang, F., Wu, K., Xu, Y., Zhou, H., Du, D. et al., Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice. Transplantation 2009. 88: 782-790.
30. Niwa, H., Yamamura, K. and Miyazaki, J., Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991. 108: 193-199.
31. Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. and Nishimune, Y., 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 1997. 407: 313-319.
32. Blanco, B., Perez-Simon, J. A., Sanchez-Abarca, L. I., Carvajal-Vergara, X., Mateos, J., Vidriales, B., Lopez-Holgado, N. et al., Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines. Blood 2006. 107: 3575-3583.
33. Zhu, M., Wei, M. F., Liu, F., Shi, H. F. and Wang, G., Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival. World J. Gastroenterol. 2003. 9: 2509-2512.
34. Gerbitz, A., Ewing, P., Wilke, A., Schubert, T., Eissner, G., Dietl, B., Andreesen, R. et al., Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biol. Blood Marrow Transplant. 2004. 10: 461-472.