Contamination with recombinant IFN accounts for the unexpected stimulatory properties of commonly used IFN-blocking antibodies

European Journal of Immunology

Volumn 41, Issue 1, 2011, Pages 252-254

  Moll, Herwig P ^a   Freudenthaler, Harald ^a   Zommer, Anna ^a   Buchberger, Elisabeth ^a   Lin, Xiao Hong ^b   Crisafulli, Sara ^b   Pandya, Yognandan ^b   Pestka, Sidney ^b   Lavoie, Thomas ^b   Brostjan, Christine ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b PBL InterferonSource   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERFERON ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RECOMBINANT INTERFERON;

CROSS REACTION; DRUG CONTAMINATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG SYNTHESIS; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BLOCKING; DRUG CONTAMINATION; HUMANS; INTERFERON TYPE I, RECOMBINANT; MICE; MICE, INBRED BALB C; MICE, SCID;

EID: 78650334844     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200940145     Document Type: Note

References (4)

1. Pestka, S., J. Biol. Chem. 2007. 282: 20047-20051.
2. Moll, H. P. et al., J. Immunol. 2008. 180: 5250-5256.
3. Colonna, M., Eur. J. Immunol. 2007. 37: 306-309.
4. Saito, T. et al., Curr. Opin. Immunol. 2007. 19: 17-23.