Brain functions after sports-related concussion: Insights from event-related potentials and functional MRI

Physician and Sportsmedicine

Volumn 38, Issue 3, 2010, Pages 27-37

  Gosselin, Nadia ^a,b   Saluja, Rajeet Singh ^a,b   Chen, Jen Kai ^a,b   Bottari, Carolina ^a,b,c   Johnston, Karen ^d,e   Ptito, Alain ^a,b,f  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d TORONTO REHABILITATION INSTITUTE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Athletes; Concussion; Event related potentials; Functional magnetic resonance imaging; Mild traumatic brain injury; Sports

Indexed keywords

ANXIETY; ATTENTION DEFICIT DISORDER; BLURRED VISION; BRAIN CONCUSSION; BRAIN FUNCTION; DECISION MAKING; DEPRESSION; DIZZINESS; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; FATIGUE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEADACHE; HUMAN; IRRITABILITY; MEMORY DISORDER; POSTCONCUSSION SYNDROME; PSYCHOMOTOR DISORDER; REVIEW; SIGNAL TRANSDUCTION; SLEEP DISORDER; SPORT INJURY; TRAUMATIC BRAIN INJURY;

ATHLETIC INJURIES; BRAIN CONCUSSION; DECISION MAKING; EVOKED POTENTIALS; HUMANS; INCIDENCE; MAGNETIC RESONANCE IMAGING; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS;

EID: 78650329654     PISSN: 00913847     EISSN: None     Source Type: Journal    
DOI: 10.3810/psm.2010.10.1805     Document Type: Review

References (71)

1. Schulz MR, Marshall SW, Mueller FO, et al. Incidence and risk factors for concussion in high school athletes, North Carolina, 1996-1999. Am J Epidemiol. 2004;160(10):937-944.
2. Delaney JS, Lacroix VJ, Leclerc S, Johnston KM. Concussions among university football and soccer players. Clin J Sport Med. 2002;12(6):331-338.
3. McCrea M, Hammeke T, Olsen G, Leo P, Guskiewicz K. Unreported concussion in high school football players: implications for prevention. Clin J Sport Med. 2004;14(1):13-17. (Pubitemid 38057637)
4. Zemper ED. Two-year prospective study of relative risk of a second cerebral concussion. Am J Phys Med Rehabil. 2003;82(9):653-659.
5. Koh JO, Cassidy JD, Watkinson EJ. Incidence of concussion in contact sports: a systematic review of the evidence. Brain Inj. 2003;17(10):901-917.
6. Agel J, Dompier TP, Dick R, Marshall SW. Descriptive epidemiology of collegiate men's ice hockey injuries: National Collegiate Athletic Association Injury Surveillance System, 1988-1989 through 2003-2004. J Athl Train. 2007;42(2):241-248.
7. Gessel LM, Fields SK, Collins CL, Dick RW, Comstock RD. Concussions among United States high school and collegiate athletes. J Athl Train. 2007;42(4):495-503. (Pubitemid 351377897)
8. Emery CA, Meeuwisse WH, McAllister JR. Survey of sport participation and sport injury in Calgary and area high schools. Clin J Sport Med. 2006;16(1):20-26.
9. Flik K, Lyman S, Marx RG. American collegiate men's ice hockey: an analysis of injuries. Am J Sports Med. 2005;33(2):183-187.
10. Bailes JE, Cantu RC. Head injury in athletes. Neurosurgery. 2001;48(1): 26-45.
11. Cassidy JD, Carroll LJ, Peloso PM, et al; WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med. 2004;(43 suppl):28-60.
12. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2(7872):81-84.
13. McCrory P, Meeuwisse W, Johnston K, et al. Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Br J Sports Med. 2009;43(suppl 1):i76-i90.
14. Bleiberg J, Cernich AN, Cameron K, et al. Duration of cognitive impairment after sports concussion. Neurosurgery. 2004;54(5):1073-1078. (Pubitemid 38585920)
15. Diagnostic and Statistical Manual of Mental Disorders, Text Revision. 4th ed. Washington DC: American Psychiatric Association; 2000.
16. Jotwani V, Harmon KG. Postconcussion syndrome in athletes. Curr Sports Med Rep. 2010;9(1):21-26.
17. Johnston KM, Bloom GA, Ramsay J, et al. Current concepts in concussion rehabilitation. Curr Sports Med Rep. 2004;3(6):316-323.
18. Cantu RC. Return to play guidelines after a head injury. Clin Sports Med. 1998;17(1):45-60.
19. Echemendia RJ, Cantu RC. Return to play following sports-related mild traumatic brain injury: the role for neuropsychology. Appl Neuropsychol. 2003;10(1):48-55.
20. Cantu RC. Second-impact syndrome. Clin Sports Med. 1998;17(1): 37-44.
21. Saunders RL, Harbaugh RE. The second impact in catastrophic contact-sports head trauma. JAMA. 1984;252(4):538-539.
22. McCrory P, Johnston K, Meeuwisse W, et al. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. Br J Sports Med. 2005;39(4):196-204. (Pubitemid 40478202)
23. Vagnozzi R, Signoretti S, Tavazzi B, et al. Temporal window of metabolic brain vulnerability to concussion: a pilot 1H-magnetic resonance spectroscopic study in concussed athletes - part III. Neurosurgery. 2008;62(6):1286-1295.
24. Guskiewicz KM, Marshall SW, Bailes J, et al. Association between recurrent concussion and late-life cognitive impairment in retired professional football players. Neurosurgery. 2005;57(4):719-726.
25. Guskiewicz KM, Marshall SW, Bailes J, et al. Recurrent concussion and risk of depression in retired professional football players. Med Sci Sports Exerc. 2007;39(6):903-909.
26. Ellemberg D, Henry LC, Macciocchi SN, Guskiewicz KM, Broglio SP. Advances in sport concussion assessment: from behavioral to brain imaging measures. J Neurotrauma. 2009;26(12):2365-2382.
27. Picton TW. The P300 wave of the human event-related potential. J Clin Neurophysiol. 1992;9(4):456-479.
28. Kramer AF, Strayer DL. Assessing the development of automatic processing: an application of dual-task and event-related brain potential methodologies. Biol Psychol. 1988;26(1-3):231-267.
29. Wickens C, Kramer A, Vanasse L, Donchin E. Performance of concurrent tasks: a psychophysiological analysis of the reciprocity of information- processing resources. Science. 1983;221(4615):1080-1082. (Pubitemid 13041966)
30. Kutas M, McCarthy G, Donchin E. Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science. 1977;197(4305): 792-795.
31. McCarthy G, Donchin E. A metric for thought: a comparison of P300 latency and reaction time. Science. 1981;211(4477):77-80.
32. Polich J. Attention, probability, and task demands as determinants of P300 latency from auditory stimuli. Electroencephalogr Clin Neurophysiol. 1986;63(3):251-259.
33. Squires KC, Donchin E, Herning RI, McCarthy G. On the influence of task relevance and stimulus probability on event-related-potential components. Electroencephalogr Clin Neurophysiol. 1977;42(1):1-14.
34. Folstein JR, Van Petten C. Influence of cognitive control and mismatch on the N2 component of the ERP: a review. Psychophysiology. 2008;45(1): 152-170. (Pubitemid 350233271)
35. Dupuis F, Johnston KM, Lavoie M, Lepore F, Lassonde M. Concussions in athletes produce brain dysfunction as revealed by event-related potentials. Neuroreport. 2000;11(18):4087-4092. (Pubitemid 32038808)
36. Lovell MR, Iverson GL, Collins MW, et al. Measurement of symptoms following sports-related concussion: reliability and normative data for the post-concussion scale. Appl Neuropsychol. 2006;13(3):166-174.
37. Lavoie ME, Dupuis F, Johnston KM, Leclerc S, Lassonde M. Visual p300 effects beyond symptoms in concussed college athletes. J Clin Exp Neuropsychol. 2004;26(1):55-73.
38. Gosselin N, Mathieu A, Mazza S, Petit D, Malo J, Montplaisir J. Attentional deficits in patients with obstructive sleep apnea syndrome: an event-related potential study. Clin Neurophysiol. 2006;117(10):2228-2235.
39. Gosselin N, Thériault M, Leclerc S, Montplaisir J, Lassonde M. Neurophysiological anomalies in symptomatic and asymptomatic concussed athletes. Neurosurgery. 2006;58(6):1151-1161. (Pubitemid 43879549)
40. Collins MW, Lovell MR, Iverson GL, Cantu RC, Maroon JC, Field M. Cumulative effects of concussion in high school athletes. Neurosurgery. 2002;51(5):1175-1179.
41. Iverson GL, Brooks BL, Lovell MR, Collins MW. No cumulative effects for one or two previous concussions. Br J Sports Med. 2006;40(1):72-75.
42. Gaetz M, Goodman D, Weinberg H. Electrophysiological evidence for the cumulative effects of concussion. Brain Inj. 2000;14(12):1077-1088.
43. De Beaumont L, Lassonde M, Leclerc S, Theoret H. Long-term and cumulative effects of sports concussion on motor cortex inhibition. Neurosurgery. 2007;61(2):329-336. (Pubitemid 47357326)
44. Thériault M, De Beaumont L, Gosselin N, Filipinni M, Lassonde M. Electrophysiological abnormalities in well functioning multiple concussed athletes. Brain Inj. 2009;23(11):899-906.
45. Thériault M, De Beaumont L, Tremblay S, Lassonde M, Jolicoeur P. Cumulative effects of concussions in athletes revealed by electrophysiological abnormalities on visual working memory [published online ahead of print May 17, 2010]. J Clin Exp Neuropsychol.
46. Jolicoeur P, Sessa P, Dell'Acqua R, Robitaille N. On the control of visual spatial attention: evidence from human electrophysiology. Psychol Res. 2006;70(6):414-424. (Pubitemid 44569515)
47. Broglio SP, Pontifex MB, O'Connor P, Hillman CH. The persistent effects of concussion on neuroelectric indices of attention. J Neurotrauma. 2009;26(9):1463-1470.
48. De Beaumont L, Théoret H, Mongeon D, et al. Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood. Brain. 2009;132(pt 3):695-708.
49. Boutin D, Lassonde M, Robert M, Vanassing P, Ellemberg D. Neurophysiological assessment prior to and following sports-related concussion during childhood: a case study. Neurocase. 2008;14(3):239-248.
50. Hoge RD, Pike GB. Oxidative metabolism and the detection of neuronal activation via imaging. J Chem Neuroanat. 2001;22(1-2):43-52.
51. Bargallo N. Functional magnetic resonance: new applications in epilepsy. Eur J Radiol. 2008;67(3):401-408.
52. Larsen S, Kikinis R, Talos IF, Weinstein D, Wells W, Golby A. Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot. 2007;3(3):262-270.
53. Benke T, Köylü B, Visani P, et al. Language lateralization in temporal lobe epilepsy: a comparison between fMRI and the Wada Test. Epilepsia. 2006;47(8):1308-1319.
54. Dickerson BC. Advances in functional magnetic resonance imaging: technology and clinical applications. Neurotherapeutics. 2007;4(3):360-370. (Pubitemid 46970747)
55. Jantzen KJ, Anderson B, Steinberg FL, Kelso JA. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR Am J Neuroradiol. 2004;25(5):738-745. (Pubitemid 38657654)
56. Slobounov SM, Zhang K, Penneil D, Ray W, Johnson B, Sebastianelli W. Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study. Exp Brain Res. 2010;202(2): 341-354.
57. Chen J, Johnston K, Ptito A. Functional activation and volumetric studies of the hippocampus following sports concussion. Br J Sports Med. 2009;43(suppl 1):i104.
58. Mayer AR, Mannell MV, Ling J, et al. Auditory orienting and inhibition of return in mild traumatic brain injury: a FMRI study. Hum Brain Mapp. 2009;30(12):4152-4166.
59. McAllister TW, Saykin AJ, Flashman LA, et al. Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study. Neurology. 1999;53(6):1300-1308.
60. McAllister TW, Sparling MB, Flashman LA, Guerin SJ, Mamourian AC, Saykin AJ. Differential working memory load effects after mild traumatic brain injury. Neuroimage. 2001;14(5):1004-1012.
61. Smits M, Dippel DW, Houston GC, et al. Postconcussion syndrome after minor head injury: brain activation of working memory and attention. Hum Brain Mapp. 2009;30(9):2789-2803.
62. Stulemeijer M, Vos PE, Van der Werf SP, Van Dijk G, Rijpkema M, Fernandez G. How mild traumatic brain injury may affect declarative memory performance in the post-acute stage [published online ahead of print July 14, 2010]. J Neurotrauma.
63. Gosselin N, Bottari C, Chen J, et al. Dorsolateral prefrontal cortex activation related to pain after mild traumatic brain injury. J Cogn Neurosci. 2010(suppl):168.
64. Gosselin N, Bottari C, Chen J, et al. Electrophysiology and functional MRI reveal cerebral dysfunction after mild traumatic brain injury. Brain Inj. 2010;24(3):221.
65. Chen JK, Johnston KM, Collie A, McCrory P, Ptito A. A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI. J Neurol Neurosurg Psychiatry. 2007;78(11):1231-1238.
66. Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22(1):68-82. (Pubitemid 38515814)
67. Chen JK, Johnston KM, Petrides M, Ptito A. Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes. Clin J Sport Med. 2008;18(3):241-247. (Pubitemid 351670428)
68. Lovell MR, Pardini JE, Welling J, et al. Functional brain abnormalities are related to clinical recovery and time to return-to-play in athletes. Neurosurgery. 2007;61(2):352-359.
69. Chen JK, Johnston KM, Petrides M, Ptito A. Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Arch Gen Psychiatry. 2008;65(1):81-89.
70. Beck AT, Sterr RA, Brown GK. Beck Depression Inventory: Manual. 2nd ed. Boston, MA: Harcourt Brace; 1996.
71. MacQueen GM. Magnetic resonance imaging and prediction of outcome in patients with major depressive disorder. J Psychiatry Neurosci. 2009;34(5):343-349.