Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow

Stroke

Volumn 41, Issue 12, 2010, Pages 2938-2943

  Fujita, Youshi ^a   Ihara, Masafumi ^a   Ushiki, Takashi ^a,b   Hirai, Hideyo ^c   Kizaka Kondoh, Shinae ^a   Hiraoka, Masahiro ^a   Ito, Hidefumi ^a   Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

bone marrow; cerebral blood flow; eNOS; white matter

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTERY OCCLUSION; ARTICLE; BONE MARROW CELL; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CELL ASSAY; CELL DAMAGE; CELL THERAPY; COMMON CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME BLOOD LEVEL; IMAGE ANALYSIS; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; OLIGODENDROGLIA; PERICYTE; PRIORITY JOURNAL; WHITE MATTER;

ANIMALS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CAPILLARIES; CAROTID STENOSIS; CELL DIFFERENTIATION; CEREBROVASCULAR CIRCULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78650318086     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.596379     Document Type: Article

References (28)

1. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32:1005-1011. (Pubitemid 32285175)
2. Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothe-lial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res. 2002;90:284-288.
3. Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003;92:692-699. (Pubitemid 36417705)
4. Chopp M, Li Y, Zhang ZG. Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies. Stroke. 2009;40:S143-145.
5. You D, Waeckel L, Ebrahimian TG, Blanc-Brude O, Foubert P, Barateau V, Duriez M, Lericousse-Roussanne S, Vilar J, Dejana E, Tobelem G, Lévy BI, Silvestre JS. Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy. Circulation. 2006;114:328-338.
6. Khan A, Ashrafpour H, Huang N, Neligan PC, Kontos C, Zhong A, Forrest CR, Pang CY. Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1219-R1229.
7. Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoper-fusion. Stroke. 2004;35:2598-2603.
8. Erkinjuntti T, Román G, Gauthier S, Feldman H, Rockwood K. Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke. 2004;35:1010-1017.
9. Skelton D, Satake N, Kohn DB. The enhanced green fluorescent protein (eGFP) is minimally immunogenic in C57BL/6 mice. Gene Ther. 2001; 8:1813-1814.
10. MacKenzie GM, Rose S, Bland-Ward PA, Moore PK, Jenner P, Marsden CD. Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole. Neuroreport. 1994;5:1993-1996.
11. Strehlow K, Werner N, Berweiler J, Link A, Dirnagl U, Priller J, Laufs K, Ghaeni L, Milosevic M, Böhm M, Nickenig G. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation. 2003;107:3059-3065.
12. Ayata C, Dunn AK, Gursoy-OZdemir Y, Huang Z, Boas DA, Moskowitz MA. Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse. J Cereb Blood Flow Metab. 2004;24:744-755.
13. Krueger M, Bechmann I. CNS pericytes: concepts, misconceptions, and a way out. Glia. 2010;58:1-10.
14. Fisher M. Pericyte signaling in the neurovascular unit. Stroke. 2009;40(3 Suppl):S13-S15.
15. Borlongan CV, Lind JG, Dillon-Carter O, Yu G, Hadman M, Cheng C, Carroll J, Hess DC. Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats. Brain Res. 2004;1010:108-116.
16. Onda T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD. Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:329-340.
17. Osuka K, Watanabe Y, Usuda N, Nakazawa A, Tokuda M, Yoshida J. Modification of endothelial NO synthase through protein phosphorylation after forebrain cerebral ischemia/reperfusion. Stroke. 2004;35:2582-2586.
18. Ahmad S, Hewett PW, Wang P, Al-Ani B, Cudmore M, Fujisawa T, Haigh JJ, le Noble F, Wang L, Mukhopadhyay D, Ahmed A. Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res. 2006;99:715-722.
19. Benyó Z, Szabó C, Stuiver BT, Bohus B, Sándor P. Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. Neurosci Lett. 1995;198:127-130.
20. Kelly PA, Ritchie IM, McBean DE. 7-nitroindazole reduces cerebral blood flow following chronic nitric oxide synthase inhibition. Brain Res. 2000;885:295-297.
21. Hortobágyi L, Kis B, Hrabák A, Horváth B, Huszty G, Schweer H, Benyó B, Sándor P, Busija DW, Benyó Z. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. Brain Res. 2007;1131:129-137.
22. Li Y, Chen J, Chen XG, Wang L, Gautam SC, Xu YX, Katakowski M, Zhang LJ, Lu M, Janakiraman N, Chopp M. Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology. 2002;59:514-523.
23. Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD. I.V. infusion of brain-derived neurotrophic factor gene-modified human mes-enchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience. 2005;136:161-169.
24. Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, Carothers J. Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke. Stroke. 2002;33:1362-1368.
25. Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, Helisch A, Schaper W. Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res. 2004;94:230-238.
26. O'Neill TJ IV, Wamhoff BR, Owens GK, Skalak TC. Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells. Circ Res. 2005;97:1027-1035.
27. Zhang J, Li Y, Zheng X, Gao Q, Liu Z, Qu R, Borneman J, Elias SB, Chopp M. Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury. J Neurosci Res. 2008;86:1501-1510.
28. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009;29:4351-4355.