Reappraisal of a single-tissue compartment model for estimation of myocardial oxygen consumption by [11C]acetate PET: An alternative to conventional monoexponential curve fitting

Nuclear Medicine Communications

Volumn 32, Issue 1, 2011, Pages 59-62

  Timmer, Stefan A J ^a   Lubberink, Mark ^a   Van Rossum, Albert C ^a   Lammertsma, Adriaan A ^a   Knaapen, Paul ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

11C acetate; monoexponential curve fitting; myocardial oxygen consumption; positron emission tomography

Indexed keywords

ACETIC ACID C 11;

ADULT; ARTICLE; COMPARTMENT MODEL; EXPERIMENTAL MODEL; FEMALE; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; INTERMETHOD COMPARISON; MALE; MONOEXPONENTIAL CURVE FITTING; NON INVASIVE PROCEDURE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY;

ACETATES; CARBON; FEMALE; HEART; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MYOCARDIUM; OXYGEN; POSITRON-EMISSION TOMOGRAPHY;

EID: 78650310014     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32834113b0     Document Type: Article

References (11)

1. Armbrecht JJ, Buxton DB, Brunken RC, Phelps ME, Schelbert HR. Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography. Circulation 1989; 80:863-872.
2. Armbrecht JJ, Buxton DB, Schelbert HR. Validation of [1-11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Circulation 1990; 81:1594-1605.
3. Buxton DB, Nienaber CA, Luxen A, Ratib O, Hansen H, Phelps ME, et al Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography. Circulation 1989; 79:134-142.
4. Sun KT,Yeatman LA, Buxton DB, Chen K, Johnson JA, Huang SC, et al. Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate. J Nucl Med 1998; 39: 272-280.
5. Buck A, Wolpers HG, Hutchins GD, Savas V, Mangner TJ, Nguyen N, et al. Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. J Nucl Med 1991; 32:1950-1957
6. Van den Hoff J, Burchert W, Borner AR, Fricke H, Kuhnel G, Meyer GJ, et al. [1-(11)C]Acetate as a quantitative perfusion tracer in myocardial PET. J Nucl Med 2001; 42:1174-1182.
7. Holmberg S, Serzysko W, Varnauskas E. Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease. Acta Med Scand 1971; 190:465-480.
8. Kitamura K, Jorgensen CR, Gobel FL, Taylor HL, Wang Y. Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J Appl Physiol 1972; 32:516-522.
9. Nelson RR, Gobel FL, Jorgensen CR, Wang K, Wang Y, Taylor HL Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise. Circulation 1974; 50:1179-1189.
10. Choi Y, Huang SC, Hawkins RA, Hoh CK, Krivokapich J, Buxton DB, et al. A refined method for quantification of myocardial oxygen consumption rate using mean transit time with carbon-11-acetate and dynamic PET. J Nucl Med 1993; 34:2038-2043.
11. Ng CK, Huang SC, Schelbert HR, Buxton DB. Validation of a model for [1-11C]acetate as a tracer of cardiac oxidative metabolism. Am J Physiol 1994; 266:H1304-H1315.