Propionibacterium acnes activates the IGF-1/IGF-1R system in the epidermis and induces keratinocyte proliferation

Journal of Investigative Dermatology

Volumn 131, Issue 1, 2011, Pages 59-66

  Isard, Olivia ^a   Knol, Anne C ^a   Ariès, Marie F ^b   Nguyen, Jean M ^c   Khammari, Amir ^a,d   Castex Rizzi, Nathalie ^b   Dréno, Brigitte ^a,d  

^a Team 12   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^c CHU DE NANTES   (France)

^d NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN; GLUCONATE ZINC; KI 67 ANTIGEN; MESSENGER RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ACNE VULGARIS; ARTICLE; CELL PROLIFERATION; COMEDO; DOWN REGULATION; EPIDERMIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES;

EID: 78650300365     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.281     Document Type: Article

References (53)

1. Aizawa H, Niimura M (1995) Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. J Dermatol 22: 249-52
2. Banudevi S, Senthilkumar K, Sharmila G et al. (2010) Effect of zinc on regulation of insulin-like growth factor signaling in human androgen-independent prostate cancer cells. Clin Chim Acta 411:172-8
3. Barreca A, De Luca M, Del Monte P et al. (1992) In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J Cell Physiol 151:262-8
4. Bruggemann H, Henne A, Hoster F et al. (2004) The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science 305:671-3
5. Cappel M, Mauger D, Thiboutot D (2005) Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol 141:333-8
6. Crowe FL, Key TJ, Allen NE et al. (2009) The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 18:1333-40
7. Davidovici BB, Wolf R (2010) The role of diet in acne: facts and controversies. Clin Dermatol 28:12-6
8. Dreno B, Amblard P, Agache P et al. (1989) Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol 69:541-3
9. Dreno B, Foulc P, Reynaud A et al. (2005) Effect of zinc gluconate on Propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study. Eur J Dermatol 15:152-5
10. Dreno B, Trossaert M, Boiteau HL et al. (1992) Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Acta Derm Venereol 72:250-2
11. Edmondson SR, Thumiger SP, Kaur P et al. (2005) Insulin-like growth factor binding protein-3 (IGFBP-3) localizes to and modulates proliferative epidermal keratinocytes in vivo. Br J Dermatol 152:225-30
12. Eichenfield LF, Leyden JJ (1991) Acne: current concepts of pathogenesis and approach to rational treatment. Pediatrician 18:218-23
13. Elgavish A, Lloyd K, Reed R (1996) A subpopulation of human urothelial cells is stimulated to proliferate by treatment in vitro with lipoteichoic acid, a cell wall component of Streptococcus faecalis. J Cell Physiol 169:42-51
14. Fluhr JW, Bosch B, Gloor M et al. (1999) In-vitro and in-vivo efficacy of zinc acetate against propionibacteria alone and in combination with erythromycin. Zentralbl Bakteriol 289:445-56
15. Gilhar A, Ish-Shalom S, Pillar T et al. (1994) Effect of antiinsulin-like growth factor 1 on epidermal proliferation of human skin transplanted onto nude mice treated with growth hormone. Endocrinology 134:229-32
16. Grimberg A, Cohen P (2000) Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 183:1-9
17. Hodak E, Gottlieb AB, Anzilotti M et al. (1996) The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia. J Invest Dermatol 106:564-70
18. Jarrousse V, Castex-Rizzi N, Khammari A et al. (2007a) Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytes. Arch Dermatol Res 299:441-7
19. Jarrousse V, Castex-Rizzi N, Khammari A et al. (2007b) Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol 17:492-6
20. Jugeau S, Tenaud I, Knol AC et al. (2005) Induction of toll-like receptors by Propionibacterium acnes. Br J Dermatol 153:1105-13
21. Karadag AS, Ertugrul DT, Tutal E et al. (2010) Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology? Br J Dermatol 162:798-802
22. Knaggs HE, Holland DB, Morris C et al. (1994) Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Invest Dermatol 102:89-92
23. Krane JF, Murphy DP, Carter DM et al. (1991) Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor. J Invest Dermatol 96:419-24
24. Liu JP, Baker J, Perkins AS et al. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72
25. Melnik B (2009) Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies. J Dtsch Dermatol Ges 7:364-70
26. Melnik B (2010) [Acne vulgaris. Role of diet]. Hautarzt 61:115-25
27. Melnik BC, Schmitz G (2009) Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol 18:833-41
28. Meynadier J (2000) Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne. Eur J Dermatol 10:269-73
29. Michaelsson G, Ljunghall K (1990) Patients with dermatitis herpetiformis, acne, psoriasis and Darier's disease have low epidermal zinc concentrations. Acta Derm Venereol 70:304-8
30. Nagy I, Pivarcsi A, Kis K et al. (2006) Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect 8:2195-205
31. Nagy I, Pivarcsi A, Koreck A et al. (2005) Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol 124:931-8
32. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
33. Qin LQ, He K, Xu JY (2009) Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review. Int J Food Sci Nutr 60(Suppl 7):330-40
34. Ristow HJ, Messmer TO (1988) Basic fibroblast growth factor and insulin-like growth factor I are strong mitogens for cultured mouse keratinocytes. J Cell Physiol 137:277-84
35. Rodrigues LS, da Silva Maeda E, Moreira ME et al. (2010) Mycobacterium leprae induces insulin-like growth factor and promotes survival of Schwann cells upon serum withdrawal. Cell Microbiol 12:42-54
36. Rudman SM, Philpott MP, Thomas GA et al. (1997) The role of IGF-I in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol 109:770-7
37. Sadagurski M, Yakar S, Weingarten G et al. (2006) Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol 26:2675-87
38. Schachner L, Eaglstein W, Kittles C et al. (1990) Topical erythromycin and zinc therapy for acne. J Am Acad Dermatol 22:253-60
39. Schaller M, Loewenstein M, Borelli C et al. (2005) Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br J Dermatol 153:66-71
40. Singh B, Charkowicz D, Mascarenhas D (2004) Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3. J Biol Chem 279:477-87
41. Smith TM, Cong Z, Gilliland KL et al. (2006) Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol 126:1226-32
42. Smith TM, Gilliland K, Clawson GA et al. (2008) IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 128:1286-93
43. Spencer EH, Ferdowsian HR, Barnard ND (2009) Diet and acne: a review of the evidence. Int J Dermatol 48:339-47
44. Stray SJ, Ceres P, Zlotnick A (2004) Zinc ions trigger conformational change and oligomerization of hepatitis B virus capsid protein. Biochemistry 43:9989-98
45. Sugisaki H, Yamanaka K, Kakeda M et al. (2009) Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. J Dermatol Sci 55:47-52
46. Tavakkol A, Varani J, Elder JT et al. (1999) Maintenance of human skin in organ culture: role for insulin-like growth factor-1 receptor and epidermal growth factor receptor. Arch Dermatol Res 291:643-51
47. Thiboutot DM (1997) Acne. An overview of clinical research findings. Dermatol Clin 15:97-109
48. Valentinis B, Baserga R (2001) IGF-I receptor signalling in transformation and differentiation. Mol Pathol 54:133-7
49. Vora S, Ovhal A, Jerajani H et al. (2008) Correlation of facial sebum to serum insulin-like growth factor-1 in patients with acne. Br J Dermatol 159:990-1
50. Vowels BR, Yang S, Leyden JJ (1995) Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 63:3158-65
51. Wille JJ, Park J, Elgavish A (1992) Effects of growth factors, hormones, bacterial lipopolysaccharides, and lipotechoic acids on the clonal growth of normal ureteral epithelial cells in serum-free culture. J Cell Physiol 150:52-8
52. Yamaoka J, Kume T, Akaike A et al. (2000) Suppressive effect of zinc ion on iNOS expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocytes. J Dermatol Sci 23:27-35
53. Zouboulis CC, Eady A, Philpott M et al. (2005) What is the pathogenesis of acne? Exp Dermatol 14:143-52